The reaction of NO with superoxide
Abstract
The rate constant for the reaction of NO with .O2- was determined to be (6.7 +/- 0.9) x 10(9) l mol-1 s-1, considerably higher than previously reported. Rate measurements were made from pH 5.6 to 12.5 both by monitoring the loss of .O2- and the formation of the product -OONO. The decay rate of -OONO, in the presence of 0.1 mol l-1 formate, ranges from 1.2 s-1 at pH 5 to about 0.2 s-1 in strong base, the latter value probably reflecting catalysis by formate.
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O2•− can rapidly react with other radicals to give other reactive species.
“However, O2•− can rapidly react with other radicals to give other reactive species [22].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [22]
The reaction of •NO with superoxide has a very high rate constant and is fast enough to compete with SOD-catalysed dismutation.
“This reaction has a very high rate constant and is fast enough to compete with SOD-catalysed dismutation [22,118].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [22]
Superoxide reacts rapidly with nitric oxide, generating peroxynitrite, which can impair proteins involved in electron transport.
“Moreover, superoxide is known to react very rapidly with NO (107), generating a damaging peroxynitrite (ONOO−) radical (98, 144, 246), which can impair proteins involved in electron transport (261).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [144]
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Koppenol, W. H. (2001) · Redox Report · doi:10.1179/135100001101536517 · Cited by 41 · see citing works
Casella, L., Monzani, E., Roncone, R., Nicolis, S., Sala, A., & De Riso, A. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s5709 · Cited by 30 · see citing works
Pei, R., Mah, E., Leonard, S. W., Traber, M. G., & Bruno, R. S. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1040788 · Cited by 14 · see citing works
Nitrite reduction: a ubiquitous function from a pre-aerobic past
Cutruzzolà, F., Rinaldo, S., Castiglione, N., Giardina, G., Pecht, I., & Brunori, M. (2009) · BioEssays · doi:10.1002/bies.200800235 · Cited by 13 · see citing works
- Authors
- Huie, R. E., & Padmaja, S.
- Affiliations
- National Institute of Standards and Technology (US)
- Venue
- Free Radical Research Communications
- Publisher
- Informa UK Limited
- Published
- 1993-01
- Volume
- 18
- Issue
- 4
- Pages
- 195-199
- ISSN
- 8755-0199 (ISSN-L)
- OpenAlex
- W2109893157
- Cited by
- 2,121
- References
- 18
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 26 · 2023: 29 · 2022: 34 · 2021: 34 · 2020: 27 · 2019: 18 · 2018: 33 · 2017: 39 · 2016: 43 · 2015: 56 · 2014: 64 · 2013: 55 · 2012: 54
- FWCI
- 69.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- nitric oxide, superoxide, rate constants, nitroxyl, pH dependence, reaction kinetics
- MeSH terms
- Hydrogen-Ion Concentration, Kinetics, Lasers, Nitrates, Nitric Oxide, Photolysis, Solutions, Spectrophotometry, Superoxides
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