CoChat
Sign Up
Cited by 30Alzheimer's disease research and treatmentsMemory and Neural MechanismsCoagulation, Bradykinin, Polyphosphates, and Angioedema

Participation of kinin receptors on memory impairment after chronic infusion of human amyloid-β 1-40 peptide in mice

Amaral, Fabio Agostini, Lemos, Mayra Tolentino Resk, Dong, Karis Ester, Bittencourt, Maria Fernanda Queiroz Prado, Caetano, Ariadiny Lima, Pesquero, João Bosco, Viel, Tania Araujo, Buck, Hudson Sousa·2010·Neuropeptides
DOI 10.1016/j.npep.2009.10.006
Open this paper in CoChat — free account

Abstract

Chronic infusion of human amyloid-beta 1-40 (Abeta) in the lateral ventricle (LV) of rats is associated with memory impairment and increase of kinin receptors in cortical and hippocampal areas. Deletion of kinin B1 or B2 receptors abolished memory impairment caused by an acute single injection of Abeta in the LV. As brain tissue and kinin receptors could unlikely react to acute or chronic administration of a similar quantity of Abeta, we evaluated the participation of B1 or B2 receptors in memory impairment after chronic infusion of Abeta. Male C57Bl/6J (wt), knock-out B1 (koB1) or B2 (koB2) mice (12weeks of age) previously trained in a two-way shuttle-box and achieving conditioned avoidance responses (CAR, % of 50 trials) were infused with AB (550pmol, 0.12microL/h, 28days) or vehicle in the LV using a mini-osmotic pump. They were tested before the surgery (T0), 7 and 35days after the infusion started (T7; T35). In T0, no difference was observed between CAR of the control (Cwt=59.7+/-6.7%; CkoB1=46.7+/-4.0%; CkoB2=64.4+/-5.8%) and Abeta (Abetawt=66.0+/-3.0%; AbetakoB1=66.8+/-8.2%; AbetakoB2=58.7+/-5.9%) groups. In T7, AbetakoB2 showed a significant decrease in CAR (41.0+/-8.6%) compared to the control-koB2 (72.8+/-2.2%, P<0.05). In T35, a significant decrease (P<0.05) was observed in Abetawt (40.7+/-3.3%) and AbetakoB2 (41.2+/-10.7%) but not in the AbetakoB1 (64.0+/-14.0%) compared to their control groups. No changes were observed in the controls at T35. We suggest that in c…

Integrity signals

Registry

Crossref · 10.1016/j.npep.2009.10.006

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The notion that Aβ aggregates are not sufficient to induce memory dysfunction in mice does not contradict studies showing that synthetic Aβ or Aβ aggregates injected into rodent brain may mediate memory formation.

    “The notion that Aβ aggregates are not sufficient to induce memory dysfunction in mice does not contradict the results of the studies that show that synthetic Aβ or Aβ aggregates injected into rodent brain may mediate memory formation e.g. [28,57].”

    From Normal cognition in transgenic BRI2-Aβ mice (2013) · cites this paper as [28]

Cited by

Sorted by citations

Authors
Amaral, F. A., Lemos, M. T. R., Dong, K. E., Bittencourt, M. F. Q. P., Caetano, A. L., Pesquero, J. B., Viel, T. A., & Buck, H. S.
Affiliations
  • Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
  • Universidade Federal de São Paulo (BR)
ORCID
Venue
Neuropeptides
Publisher
Elsevier BV
Published
2010-04
Volume
44
Issue
2
Pages
93-97
ISSN
0143-4179 (ISSN-L)
DOI
10.1016/j.npep.2009.10.006
OpenAlex
W2039709943
Cited by
30
References
0
Citations by year
2025: 3 · 2024: 1 · 2020: 2 · 2019: 5 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 1
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuropeptides (publishedVersion)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Keywords
Aβ40, kinin B1 receptor, kinin B2 receptor, memory impairment, conditioned avoidance response, receptor knockout mice, neurodegeneration, Alzheimer's disease, lateral ventricle, hippocampus, cortex, kallikrein-kinin system, neuroprotection, neuroinflammation
MeSH terms
Analysis of Variance, Animals, Avoidance Learning, Brain, Male, Memory, Memory Disorders, Motor Activity, Neurons, Peptide Fragments, Amyloid beta-Peptides, Mice, Knockout, Receptor, Bradykinin B2, Receptor, Bradykinin B1, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review