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Cited by 3Psychedelics and Drug StudiesNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record.

Pharmacokinetics and pharmacokinetic-pharmacodynamic relationship of oral psilocybin administration in healthy subjects

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Holze, F., Becker, A.M., Kolaczynska, K.E., Duthaler, U., Liechti, M.E.·2022·Neuroscience Applied
DOI 10.1016/j.nsa.2022.100410
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Abstract

NR2A (F¼6.034,p<0.05),NR2B (F¼5,588, p<0.05) and vGluT1 (F¼14.103,p<0.01).Significant increase of all investigated proteins, compared to control was detected (NR1, NR2A, NR2B p<0.05; vGluT1 p<0.01).Conclusion: GABAergic and glutamatergic neurotransmission is crucial for neuronal excitability, integrity and synaptic plasticity.Our results suggest that repeated administration of zaleplon at a lower dose significantly increases protein expression of NR1, NR2A, NR2B and vGluT1.These results, together with our previous findings show that a repeated lower dose of zaleplon increases protein expression of GABAAα receptor subunit and GABA transporter level, indicating marked GABA and glutamate signalling in the hippocampus.Given the importance of GABA/glutamate balance the effects of zaleplon play an important role in maintaining GABA/glutamate balance.

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Crossref · 10.1016/j.nsa.2022.100410

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Metadata

Authors
Holze, F., Becker, A. M., Kolaczynska, K. E., Duthaler, U., & Liechti, M. E.
Affiliations
University of Basel (CH)
ORCID
Venue
Neuroscience Applied
Publisher
Elsevier BV
Published
2022
Volume
1
Pages
100410
ISSN
2772-4085 (ISSN-L)
DOI
10.1016/j.nsa.2022.100410
OpenAlex
W4313200314
Cited by
3
References
0
Citations by year
2025: 1 · 2024: 2
FWCI
0.69
Type
journal article
Language
en
Open access
Licence
Locations
Neuroscience Applied (publishedVersion, cc-by-nc-nd)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
psilocybin, oral administration, pharmacokinetics, pharmacokinetic-pharmacodynamic relationship, healthy volunteers, GABAergic neurotransmission, glutamatergic neurotransmission, GABAA receptor subunits, VGLUT1, GABA transporters, hippocampus, zaleplon

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