Cited by 180Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionNeuroscience and Neuropharmacology Research

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Regional distribution of serotonin transporter protein in postmortem human brain

Kish, Stephen J., Furukawa, Yoshiaki, Chang, Li-Jan, Tong, Junchao, Ginovart, Nathalie, Wilson, Alan, Houle, Sylvain, Meyer, Jeffrey H.·2005·Nuclear Medicine and Biology

DOI 10.1016/j.nucmedbio.2004.10.001

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Abstract

Introduction The primary approach in assessing the status of brain serotonin neurons in human conditions such as major depression and exposure to the illicit drug ecstasy has been the use of neuroimaging procedures involving radiotracers that bind to the serotonin transporter (SERT). However, there has been no consistency in the selection of a "SERT-free" reference region for the estimation of free and nonspecific binding, as occipital cortex, cerebellum and white matter have all been employed.Objective and methods To identify areas of human brain that might have very low SERT levels, we measured, by a semiquantitative Western blotting procedure, SERT protein immunoreactivity throughout the postmortem brain of seven normal adult subjects.Results Serotonin transporter could be quantitated in all examined brain areas. However, the SERT concentration in cerebellar cortex and white matter were only at trace values, being approximately 20% of average cerebral cortex and 5% of average striatum values.Conclusion Although none of the examined brain areas are completely free of SERT, human cerebellar cortex has low SERT binding as compared to other examined brain regions, with the exception of white matter. Since the cerebellar cortical SERT binding is not zero, this region will not be a suitable reference region for SERT radioligands with very low free and nonspecific binding. For SERT radioligands with reasonably high free and nonspecific binding, the cerebellar cortex should be a useful reference region, provided other necessary radioligand assumptions are met.

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Authors: Kish, S. J., Furukawa, Y., Chang, L.-J., Tong, J., Ginovart, N., Wilson, A., Houle, S., & Meyer, J. H.
Affiliations: Centre for Addiction and Mental Health (CA)
Corresponding author: Kish, Stephen J.
ORCID: Kish, Stephen J.
Furukawa, Yoshiaki
Tong, Junchao
Ginovart, Nathalie
Houle, Sylvain
Meyer, Jeffrey H.
Venue: Nuclear Medicine and Biology
Publisher: Elsevier BV
Published: 2005-02
Volume: 32
Issue: 2
Pages: 123-128
ISSN: 0969-8051 (ISSN-L)
DOI: 10.1016/j.nucmedbio.2004.10.001
OpenAlex: W55536439
Cited by: 179
References: 33
Citations by year: 2026: 2 · 2025: 7 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 11
FWCI: 4.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nuclear Medicine and Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Canadian Institutes of Health Research
National Institute on Drug Abuse (DA 7182, R01DA007182)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: serotonin transporter, postmortem brain, cerebellar cortex, white matter, reference region, non-specific binding, major depressive disorder, ecstasy, serotonergic neurons
MeSH terms: Brain, Cadaver, Cerebellum, Humans, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Neurons, Reference Values, Tissue Distribution, Blotting, Western, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins

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Regional distribution of serotonin transporter protein in postmortem human brain

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