The serotonergic system in Parkinson's disease
Abstract
Although the cardinal manifestations of Parkinson's disease (PD) are attributed to a decline in dopamine levels in the striatum, a breadth of non-motor features and treatment-related complications in which the serotonergic system plays a pivotal role are increasingly recognised. Serotonin (5-HT)-mediated neurotransmission is altered in PD and the roles of the different 5-HT receptor subtypes in disease manifestations have been investigated. The aims of this article are to summarise and discuss all published preclinical and clinical studies that have investigated the serotonergic system in PD and related animal models, in order to recapitulate the state of the current knowledge and to identify areas that need further research and understanding.
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Changes in DRN 5-HT neuron function have been implicated in various neuropsychiatric diseases, including major depressive disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and movement disorders such as Parkinson's Disease.
“Changes in DRN 5-HT neuron function have been implicated in various neuropsychiatric diseases, including major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder, as well as movement disorders such as Parkinson’s Disease (Huot et al., 2011; Mahmood and Silverstone, 2001; Politis and Niccolini, 2015; Vaswani et al., 2003).”
From Molecular and anatomical organization of the dorsal raphe nucleus (2019) · cites this paper as Huot et al., 2011
Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez‐Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., et al. (2008) · Movement Disorders · doi:10.1002/mds.22340 · Cited by 7,536 · see citing works
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,143 · see citing works
Primate models of movement disorders of basal ganglia origin
DeLong, M. R. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90110-v · Cited by 3,824 · see citing works
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,150 · see citing works
Unified Parkinson's Disease Rating Scale
(2012) · Springer eBooks · doi:10.1007/springerreference_184495 · Cited by 3,071 · see citing works
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 2,997 · see citing works
Stages in the development of Parkinson’s disease-related pathology
Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689 · see citing works
Parkinson, J. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.2.223 · Cited by 2,684 · see citing works
Recent developments in Parkinson's disease
Fahn, S., Elton, R., MARSDEN, C. D., Calne, D. B., & Goldstein, M. (1986) · Raven Press eBooks · Cited by 2,306 · see citing works
Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
Parent, A., & Hazrati, L.-N. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00007-c · Cited by 2,161 · see citing works
The expanded biology of serotonin
Berger, M., Gray, J. A., & Roth, B. L. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.042307.110802 · Cited by 2,100 · see citing works
Tol, H. H. M. V., Bunzow, J. R., Guan, H., Sunahara, R. K., Seeman, P. M., Niznik, H. B., & Civelli, O. (1991) · Nature · doi:10.1038/350610a0 · Cited by 2,015 · see citing works
Recent Developments in Parkinson's Disease
Hurtig, H. I. (1987) · Neurology · doi:10.1212/wnl.37.5.893 · Cited by 1,926 · see citing works
Molecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855 · see citing works
Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
Walther, D. J., Peter, J., Bashammakh, S., Hörtnagl, H., Voits, M., Fink, H., & Bäder, M. (2003) · Science · doi:10.1126/science.1078197 · Cited by 1,576 · see citing works
Aromatic amino acids and modification of parkinsonism.
Cotzias, G., van Woert, M. H., & Schiffer, L. (1967) · New England Journal of Medicine · doi:10.1056/nejm196702162760703 · Cited by 1,501 · see citing works
Jeurgen, K., Assheuer, J., & Paxinos, G. (1997) · Medical Entomology and Zoology · Cited by 1,416 · see citing works
Parent, A., & Hazrati, L. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00008-d · Cited by 1,351 · see citing works
Modification of Parkinsonism — Chronic Treatment with L-Dopa
Cotzias, G. C., Papavasiliou, P. S., & Gellene, R. A. (1969) · New England Journal of Medicine · doi:10.1056/nejm196902132800701 · Cited by 1,287 · see citing works
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
Tecott, L. H., Sun, L. M., Akana, S. F., Strack, A. M., Lowenstein, D. H., Dallman, M. F., & Julius, D. J. (1995) · Nature · doi:10.1038/374542a0 · Cited by 1,275 · see citing works
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., & Saxena, P. R. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90207-8 · Cited by 1,259 · see citing works
Schotte, A., Janssen, P. F. M., Gommeren, W., Luyten, W. H. M. L., Gompel, P. V., Lesage, A. S., Loore, K. D., & Leysen, J. E. (1996) · Psychopharmacology · doi:10.1007/bf02245606 · Cited by 1,167 · see citing works
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Urban, J. D., Clarke, W. P., von Zastrow, M., Nichols, D. E., Kobilka, B. K., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104463 · Cited by 1,119 · see citing works
Circuits and Circuit Disorders of the Basal Ganglia
DeLong, M. R., & Wichmann, T. (2007) · Archives of Neurology · doi:10.1001/archneur.64.1.20 · Cited by 1,074 · see citing works
Leysen, J. E., Niemegeers, C. J. E., Nueten, J. M. V., & Laduron, P. M. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14623-3 · Cited by 1,071 · see citing works
The Rhesus Monkey Brain in Stereotaxic Coordinates
Paxinos, G., Huang, X., & Toga, A. W. (1999) · Research Online (University of Wollongong) · Cited by 1,070 · see citing works
Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine
Bymaster, F. P., Calligaro, D. O., Falcone, J. F., Marsh, R. D., Moore, N. A., Tye, N. C., Seeman, P. M., & Wong, D. T. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00129-n · Cited by 1,061 · see citing works
Hely, M. A., Morris, J. G. L., Reid, W. G. J., & Trafficante, R. (2005) · Movement Disorders · doi:10.1002/mds.20324 · Cited by 1,050 · see citing works
Hallucinations in Parkinson's disease: Prevalence, phenomenology and risk factors
Fénelon, G. (2000) · Brain · doi:10.1093/brain/123.4.733 · Cited by 1,035 · see citing works
Regulation of serotonin-2C receptor G-protein coupling by RNA editing
Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., & Emeson, R. B. (1997) · Nature · doi:10.1038/387303a0 · Cited by 1,010 · see citing works
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R., & Julius, D. J. (1991) · Science · doi:10.1126/science.1718042 · Cited by 978 · see citing works
Pharmacological profile of antidepressants and related compounds at human monoamine transporters
Tatsumi, M., Groshan, K., Blakely, R. D., & Richelson, E. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01393-9 · Cited by 939 · see citing works
Rothman, R. B., Baumann, M. H., Dersch, C. M., Romero, D. V., Rice, K. C., Carroll, F. I., & Partilla, J. S. (2000) · Synapse · doi:10.1002/1098-2396(20010101)39:1 · Cited by 934 · see citing works
The mysterious motor function of the basal ganglia
MARSDEN, C. D. (1982) · Neurology · doi:10.1212/wnl.32.5.514 · Cited by 924 · see citing works
Nichols, D. E., & Nichols, C. D. (2008) · Chemical Reviews · doi:10.1021/cr078224o · Cited by 895 · see citing works
Valvular Heart Disease and the Use of Dopamine Agonists for Parkinson's Disease
Zanettini, R., Antonini, A., Gatto, G., Gentile, R., Tesei, S., & Pezzoli, G. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa054830 · Cited by 882 · see citing works
Ramamoorthy, S., Bauman, A. L., Moore, K. R., Han, H. J., Yang‐Feng, T. L., Chang, A. S., Ganapathy, V., & Blakely, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2542 · Cited by 880 · see citing works
Pompeiano, M., Palacios, J. M., & Mengod, G. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90223-2 · Cited by 870 · see citing works
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site
Middlemiss, D. N., & Fozard, J. R. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90230-3 · Cited by 868 · see citing works
Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding
Kilpatrick, G. J., Jones, B. J., & Tyers, M. B. (1987) · Nature · doi:10.1038/330746a0 · Cited by 866 · see citing works
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT1A and 5‐HT1B agonists
Sprouse, J. S., & Aghajanian, G. K. (1987) · Synapse · doi:10.1002/syn.890010103 · Cited by 848 · see citing works
Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors
Leysen, J. E., Awouters, F. H. L., Kennis, L. E. J., Laduron, P. M., Vandenberk, J., & Janssen, P. A. J. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90747-5 · Cited by 843 · see citing works
Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B Receptor
Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Ségu, L., Buhot, M.-C., & Hen, R. (1994) · Science · doi:10.1126/science.8091214 · Cited by 839 · see citing works
Cloning and expression of a functional serotonin transporter from rat brain
Blakely, R., Berson, H. E., Fremeau, R. T., Caron, M. G., Peek, M. M., Prince, H. K., & Bradley, C. C. (1991) · Nature · doi:10.1038/354066a0 · Cited by 831 · see citing works
Pazos, Á., Cortés, R., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90857-1 · Cited by 824 · see citing works
Serotonin neurons of the midbrain raphe: Ascending projections
Moore, R. Y., Halaris, A. E., & Jones, B. E. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800302 · Cited by 803 · see citing works
A Review of the Pharmacological and Clinical Profile of Mirtazapine
Anttila, S. A. K., & Leinonen, E. V. J. (2001) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2001.tb00198.x · Cited by 796 · see citing works
A unique central tryptophan hydroxylase isoform
Walther, D. J., & Bäder, M. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00556-2 · Cited by 752 · see citing works
Scatton, B., Javoy-Agid, F., Rouquier, L., Dubois, B., & Agid, Y. (1983) · Brain Research · doi:10.1016/0006-8993(83)90993-9 · Cited by 727 · see citing works
Rothman, R. B., Baumann, M. H., Savage, J. E., Rauser, L., McBride, A., Hufeisen, S. J., & Roth, B. L. (2000) · Circulation · doi:10.1161/01.cir.102.23.2836 · Cited by 722 · see citing works
Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation
Schade, R., Andersohn, F., Suissa, S., Haverkamp, W., & Garbe, E. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa062222 · Cited by 714 · see citing works
Brodie, B. B., Costa, E., Dlabač, A., Neff, N. H., & Smookler, H. H. (1966) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27496-1 · Cited by 710 · see citing works
Elevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice
Heisler, L. K., Chu, H.-M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., & Tecott, L. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15049 · Cited by 704 · see citing works
Pompeiano, M., Palacios, J., & Mengod, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00440.1992 · Cited by 699 · see citing works
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
Julius, D. J., MacDermott, A. B., Axel, R., & Jessell, T. M. (1988) · Science · doi:10.1126/science.3399891 · Cited by 694 · see citing works
Increased anxiety of mice lacking the serotonin 1A receptor
Parks, C. L., Robinson, P. S., Sibille, E. L., Shenk, T. E., & Tóth, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10734 · Cited by 691 · see citing works
Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors
Pazos, Á., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90326-5 · Cited by 684 · see citing works
Molecular biology of 5-HT receptors
Boess, F., & Martin, I. L. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90059-0 · Cited by 675 · see citing works
Erspamer, V., & Asero, B. (1952) · Nature · doi:10.1038/169800b0 · Cited by 674 · see citing works
Lundblad, M., Andersson, M., Winkler, C., Kirik, D., Wierup, N., & Cenci, M. A. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01843.x · Cited by 664 · see citing works
Bobillier, P., Seguin, S., Petitjean, F., Salvert, D., Touret, M., & Jouvet, M. (1976) · Brain Research · doi:10.1016/0006-8993(76)90050-0 · Cited by 660 · see citing works
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
Alex, K. D., & Pehek, E. A. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.004 · Cited by 658 · see citing works
Brain Serotonin1A Receptor Binding Measured by Positron Emission Tomography With [11C]WAY-100635
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Grasby, P. M., & Cowen, P. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.2.174 · Cited by 642 · see citing works
Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats
Carta, M., Carlsson, T., Kirik, D., & Björklund, A. (2007) · Brain · doi:10.1093/brain/awm082 · Cited by 637 · see citing works
Extrinsic connections of the basal ganglia
Parent, A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90105-j · Cited by 633 · see citing works
5-HT3 receptors are membrane ion channels
Derkach, V. A., Surprenant, A., & NORTH, R. A. (1989) · Nature · doi:10.1038/339706a0 · Cited by 630 · see citing works
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
Ruat, M., Traiffort, É., Leurs, R., Tardivel‐Lacombe, J., Díaz, J., Arrang, J., & Schwartz, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8547 · Cited by 617 · see citing works
Low-Dose Clozapine for the Treatment of Drug-Induced Psychosis in Parkinson's Disease
The Parkinson Study Group (1999) · New England Journal of Medicine · doi:10.1056/nejm199903113401003 · Cited by 616 · see citing works
Binding of antipsychotic drugs to human brain receptors
Richelson, E., & Souder, T. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00911-5 · Cited by 608 · see citing works
A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS
Woolley, D. W., & Shaw, E. (1954) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.40.4.228 · Cited by 603 · see citing works
Monsma, F. J., Shen, Y., Ward, R. P., Hamblin, M. W., & Sibley, D. R. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13616-x · Cited by 598 · see citing works
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor
Fargin, A., Raymond, J. R., Lohse, M. J., Kobilka, B. K., Caron, M. G., & Lefkowitz, R. J. (1988) · Nature · doi:10.1038/335358a0 · Cited by 597 · see citing works
Choudhary, M. S., Craigo, S. C., Sibley, D. R., Roth, B. L., Monsma, F. J., Shen, Y., Uluer, A., & Meltzer, H. Y. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/74zp-ze10 · Cited by 592 · see citing works
Hyttel, J. (1982) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(82)80179-6 · Cited by 585 · see citing works
Carpenter's Human Neuroanatomy
Parent, A., & Carpenter, M. B. (1996) · Medical Entomology and Zoology · Cited by 561 · see citing works
The 5-HT3B subunit is a major determinant of serotonin-receptor function
Davies, P. A., Pistis, M., Hanna, M. C., Peters, J. A., Lambert, J. J., Hales, T. G., & Kirkness, E. F. (1999) · Nature · doi:10.1038/16941 · Cited by 561 · see citing works
The Neuropathologic Basis of Different Clinical Subgroups of Parkinson's Disease
Paulus, W., & Jellinger, K. A. (1991) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199111000-00006 · Cited by 556 · see citing works
A proposed new nomenclature for 5-HT receptors
Humphrey, P. P. A., Hartig, P. R., & Hoyer, D. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90016-d · Cited by 553 · see citing works
SERUM VASOCONSTRICTOR (SEROTONIN)
Rapport, M. M., Green, A. A., & Page, I. H. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57137-4 · Cited by 552 · see citing works
Jakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536 · see citing works
Serotonin Content of Some Mammalian Tissues and Urine and a Method for Its Determination
Twarog, B. M., & Page, I. H. (1953) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1953.175.1.157 · Cited by 532 · see citing works
Is there a role for 5-HT1A agonists in the treatment of depression?
Blier, P., & Ward, N. M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01643-8 · Cited by 529 · see citing works
Richelson, E., & Pfenning, M. A. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90403-5 · Cited by 529 · see citing works
Parent, A., Descarries, L., & Beaudet, A. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90050-6 · Cited by 525 · see citing works
Molecular mechanisms of L-DOPA-induced dyskinesia
Jenner, P. G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2471 · Cited by 522 · see citing works
Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies
Bézard, E., Brotchie, J., & Gross, C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35086062 · Cited by 518 · see citing works
Self-citationAghajanian, G. K., & Marek, G. J. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00051-8 · Cited by 516 · see citing works
Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T. L., Kobilka, T. S., Francke, U., Lefkowitz, R. J., & Caron, M. G. (1987) · Nature · doi:10.1038/329075a0 · Cited by 515 · see citing works
The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
Jordan, S., Koprivica, V., Chen, R., Tottori, K., Kikuchi, T., & Altar, C. A. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01532-7 · Cited by 512 · see citing works
Riad, M., Garcia, S., Watkins, K. C., Jodoin, N., Doucet, �., Langlois, X., Mestikawy, S. E., Hamon, M., & Descarries, L. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000207)417:2 · Cited by 502 · see citing works
Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens
Yoshimoto, K., McBride, W. J., Lumeng, L., & Li, T. (1992) · Alcohol · doi:10.1016/0741-8329(92)90004-t · Cited by 499 · see citing works
Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)
Hyttel, J. (1994) · International Clinical Psychopharmacology · doi:10.1097/00004850-199403001-00004 · Cited by 492 · see citing works
Thigpen, N., & Keil, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02456-1 · Cited by 490 · see citing works
Miyasaki, J. M., Shannon, K. M., Voon, V., Ravina, B. M., Kleiner‐Fisman, G., Anderson, K., Shulman, L. M., Gronseth, G., & Weiner, W. J. (2006) · Neurology · doi:10.1212/01.wnl.0000215428.46057.3d · Cited by 488 · see citing works
Santana, N. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh070 · Cited by 486 · see citing works
Millan, M. J., Maiofiss, L., Cussac, D., Audinot, V., Boutin, J. A., & Newman‐Tancredi, A. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.039867 · Cited by 485 · see citing works
Drugs and Valvular Heart Disease
Roth, B. L. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068265 · Cited by 479 · see citing works
Levodopa motor complications in Parkinson's disease
Obeso, J. A., Olanow, C. W., & Nutt, J. G. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00031-8 · Cited by 478 · see citing works
Fabbrini, G., Brotchie, J. M., Grandas, F., Nomoto, M., & Goetz, C. G. (2007) · Movement Disorders · doi:10.1002/mds.21475 · Cited by 465 · see citing works
Self-citationLeysen, J. E., Gommeren, W., Gompel, P. V., Wynants, J., Janssen, P. F. M., & Laduron, P. M. (1985) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12558-3 · Cited by 452 · see citing works
Dumuis, A., Bouhelal, R., Sebben, M., Cory, R. N., & Bockaert, J. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10130-2 · Cited by 450 · see citing works
Possible Role of Valvular Serotonin 5-HT2B Receptors in the Cardiopathy Associated with Fenfluramine
Fitzgerald, L. W., Burn, T. C., Brown, B. S., Patterson, J. P., Corjay, M. H., Valentine, P. A., Sun, J., Link, J. R., Abbaszade, I. G., Hollis, J. M., et al. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26444-0 · Cited by 440 · see citing works
Cortical 5-HT 2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
Weisstaub, N., Zhou, M., Lira, A., Lambe, E. K., González‐Maeso, J., Hornung, J., Sibille, E. L., Underwood, M. D., Itohara, S., Dauer, W. T., et al. (2006) · Science · doi:10.1126/science.1123432 · Cited by 425 · see citing works
Han, D. D., & Gu, H. H. (2006) · BMC Pharmacology · doi:10.1186/1471-2210-6-6 · Cited by 419 · see citing works
Prevalence of repetitive and reward-seeking behaviors in Parkinson disease
Voon, V., Hassan, K. T., Zurowski, M., de Souza, M., Thomsen, T. R., Fox, S. H., Lang, A. E., & Miyasaki, J. M. (2006) · Neurology · doi:10.1212/01.wnl.0000238503.20816.13 · Cited by 417 · see citing works
Self-citationRuat, M., Traiffort, É., Arrang, J., Tardivel‐Lacombe, J., Díaz, J., Leurs, R., & Schwartz, J. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1619 · Cited by 413 · see citing works
Biochemical profile of risperidone, a new antipsychotic.
Leysen, J. E., Gommeren, W., Eens, A., de Courcelles, D. D. C., Stoof, J. C., & Janssen, P. A. J. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13416-2 · Cited by 412 · see citing works
L-dopa therapy in Parkinson's disease: a critical review of nine years' experience.
Barbeau, A. (1969) · PubMed · Cited by 409 · see citing works
Lawler, C. P. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00099-2 · Cited by 409 · see citing works
Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease
Halliday, G. M., Li, Y. W., Blumbergs, P. C., JOH, T. H., Cotton, R. G. H., Howe, P. R. C., Blessing, W. W., & Geffen, L. B. (1990) · Annals of Neurology · doi:10.1002/ana.410270405 · Cited by 409 · see citing works
5-HT Receptor Regulation of Neurotransmitter Release
Fink, K., & Göthert, M. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.07103 · Cited by 389 · see citing works
Chalmers, D. T., & Watson, S. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90748-k · Cited by 388 · see citing works
Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT6 Serotonin Receptor
Kohen, R., Metcalf, M. A., Khan, N. A., Druck, T., Huebner, K., Lachowicz, J. E., Meltzer, H. Y., Sibley, D. R., Roth, B. L., & Hamblin, M. W. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66010047.x · Cited by 377 · see citing works
Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
Kish, S. J., Tong, J., Hornykiewicz, O., Rajput, A. H., Chang, L.-J., Guttman, M., & Furukawa, Y. (2007) · Brain · doi:10.1093/brain/awm239 · Cited by 376 · see citing works
Aghajanian, G. K., & Marek, G. J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01224-x · Cited by 376 · see citing works
Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS
Clemett, D. A., Punhani, T., Duxon, M. S., Blackburn, T. P., & Fone, K. C. F. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00086-6 · Cited by 373 · see citing works
Aghajanian, G. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00135-3 · Cited by 371 · see citing works
Amargos-Bosch, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg128 · Cited by 370 · see citing works
The organization of divergent axonal projections from the midbrain raphe nuclei in the rat
Imai, H., Steindler, D. A., & Kitai, S. T. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902430307 · Cited by 369 · see citing works
Nervous system distribution of the serotonin 5-HT3 receptor mRNA.
Tecott, L. H., Maricq, A. V., & Julius, D. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1430 · Cited by 368 · see citing works
Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease
Halliday, G. M., Blumbergs, P. C., Cotton, R. G. H., Blessing, W. W., & Geffen, L. B. (1990) · Brain Research · doi:10.1016/0006-8993(90)90733-r · Cited by 366 · see citing works
RNA Editing of the Human Serotonin 5-Hydroxytryptamine 2C Receptor Silences Constitutive Activity
Niswender, C. M., Copeland, S. C., Herrick‐Davis, K., Emeson, R. B., & Sanders‐Bush, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9472 · Cited by 364 · see citing works
Elevated alcohol consumption in null mutant mice lacking 5–HT1B serotonin receptors
Crabbe, J. C., Phillips, T. J., Feller, D. J., Hen, R., Wenger, C. D., Lessov, C. N., & Schafer, G. L. (1996) · Nature Genetics · doi:10.1038/ng0996-98 · Cited by 360 · see citing works
Porter, R. H. P., Benwell, K. R., Lamb, H., Malcolm, C., Allen, N. H., Revell, D. F., Adams, D. R., & Sheardown, M. J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702751 · Cited by 359 · see citing works
Kehne, J. H., Baron, B. M., Carr, A. A., Chaney, S., Elands, J., Feldman, D. J., Frank, R. A., van Giersbergen, P. L. M., McCloskey, T. C., Johnson, M., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12956-x · Cited by 359 · see citing works
Costall, B., Domeney, A. M., Naylor, R. J., et al. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11394.x · Cited by 356 · see citing works
Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors
Pazos, A., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90327-7 · Cited by 355 · see citing works
The mouse 5-hydroxytryptamine 1B receptor is localized predominantly on axon terminals
Boschert, U., Amara, D. A., Ségu, L., & Hen, R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90164-3 · Cited by 352 · see citing works
Bruinvels, A. T., Landwehrmeyer, G. B., Gustafson, E. L., Durkin, M. M., Mengod, G., Branchek, T. A., Hoyer, D., & Palacios, J. M. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90067-1 · Cited by 350 · see citing works
Andersson, M., Hilbertson, A., & Cenci, M. A. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0259 · Cited by 350 · see citing works
The history of dopamine and levodopa in the treatment of Parkinson's disease
Fahn, S. (2008) · Movement Disorders · doi:10.1002/mds.22028 · Cited by 344 · see citing works
Altered serotonin metabolism in depressed patients with Parkinson's disease
Mayeux, R. P., Stern, Y., COTE, L. J., & Williams, J. B. W. (1984) · Neurology · doi:10.1212/wnl.34.5.642 · Cited by 343 · see citing works
The pathogenesis of Parkinson's disease: a new hypothesis.
Barbeau, A. (1962) · PubMed · Cited by 340 · see citing works
Nordström, A., Farde, L., Nyberg, S., Karlsson, P., Halldin, C., & Sedvall, G. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.10.1444 · Cited by 339 · see citing works
Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction
Pavese, N., Metta, V., Bose, S. K., Chaudhuri, К. R., & Brooks, D. J. (2010) · Brain · doi:10.1093/brain/awq268 · Cited by 335 · see citing works
Sprouse, J. S., & Aghajanian, G. K. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90079-2 · Cited by 333 · see citing works
Serotonin receptors: from protein to physiological function and behavior
Sari, Y. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.008 · Cited by 332 · see citing works
Pollak, P. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.029868 · Cited by 332 · see citing works
Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain.
Varnäs, K., Halldin, C., & Hall, H. (2004) · Human Brain Mapping · doi:10.1002/hbm.20035 · Cited by 332 · see citing works
The pharmacologic profile of mirtazapine.
de Boer, T. (1996) · PubMed · Cited by 330 · see citing works
Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system
Gérard, C., Martres, M., Lefèvre, K., Miquel, M., Vergé, D., Lanfumey, L., Doucet, E., Hamon, M., & Mestikawy, S. E. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01224-3 · Cited by 327 · see citing works
Seeger, T., Seymour, P. A., Schmidt, A. W., Zorn, S. H., Schulz, D. W., Lebel, L. A., McLean, S., Guanowsky, V., Howard, H. R., & Lowe, J. A., III (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12023-5 · Cited by 322 · see citing works
Treatment of Parkinson's disease with pergolide and relation to restrictive valvular heart disease
Camp, G. V., Flamez, A., Cosyns, B., Weytjens, C., Muyldermans, L., Zandijcke, M. V., SUTTER, J. D., Santens, P., Decoodt, P., Moerman, C., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15945-x · Cited by 320 · see citing works
Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson’s Patients with Neural Transplants
Politis, M., Wu, K., Loane, C., Quinn, N. P., Brooks, D. J., Rehncrona, S., Björklund, A., Lindvall, O., & Piccini, P. P. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000976 · Cited by 318 · see citing works
Organization of the basal ganglia: the importance of axonal collateralization
Parent, A., Sato, F., Wu, Y. N., Gauthier, J., Lévesque, M., & Parent, M. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00022-7 · Cited by 306 · see citing works
Setola, V., Hufeisen, S. J., Grande-Allen, K. J., Veselý, I., Glennon, R. A., Blough, B. E., Rothman, R. B., & Roth, B. L. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1223 · Cited by 305 · see citing works
Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors
Müller, C. P., Carey, R. J., Huston, J. P., & Silva, M. A. D. S. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.001 · Cited by 302 · see citing works
Tanaka, H., Kannari, K., Maeda, T., Tomiyama, M., Suda, T., & Matsunaga, M. (1999) · Neuroreport · doi:10.1097/00001756-199902250-00034 · Cited by 302 · see citing works
Tremor in Parkinson’s disease and serotonergic dysfunction
Doder, M., Rabiner, E. A., Turjanski, N., Lees, A. J., & Brooks, D. J. (2003) · Neurology · doi:10.1212/01.wnl.0000031424.51127.2b · Cited by 302 · see citing works
Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites
Battaglia, G., Brooks, B. P., Kulsakdinun, C., & Souza, E. B. D. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90056-8 · Cited by 301 · see citing works
Ondo, W. G., Tintner, R., Voung, K. D., Lai, D., & Ringholz, G. M. (2005) · Movement Disorders · doi:10.1002/mds.20474 · Cited by 297 · see citing works
Breese, G. R., Baumeister, A., McCown, T. J., et al. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21630-5 · Cited by 296 · see citing works
Weinshank, R. L., Zgombick, J. M., Macchi, M., Branchek, T. A., & Hartig, P. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3630 · Cited by 294 · see citing works
Meltzer, H. Y., Mills, R., Revell, S., Williams, H., Johnson, A. D., Bahr, D., & Friedman, J. H. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.176 · Cited by 293 · see citing works
Hoyer, D., Pazos, Á., Probst, A., & Palacios, J. M. (1986) · Brain Research · doi:10.1016/0006-8993(86)90903-0 · Cited by 291 · see citing works
Diederich, N. J., Goetz, C. G., & Stebbins, G. T. (2004) · Movement Disorders · doi:10.1002/mds.20308 · Cited by 290 · see citing works
Picchietti, D. L., Underwood, D. J., Farris, W. A., Walters, A. S., Shah, M., Dahl, R. E., Trubnick, L. J., Bertocci, M. A., Wagner, M., & Hening, W. A. (1999) · Movement Disorders · doi:10.1002/1531-8257(199911)14:6 · Cited by 289 · see citing works
SERUM VASOCONSTRICTOR (SEROTONIN)
Rapport, M. M. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51208-x · Cited by 288 · see citing works
Díaz-Mataix, L., Scorza, M. C., Bortolozzi, A. A., Tóth, M., Celada, P., & Artigas, F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2999-05.2005 · Cited by 288 · see citing works
Burnet, P. W. J. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00053-x · Cited by 286 · see citing works
Kapur, S., & Seeman, P. M. (2000) · PubMed · Cited by 285 · see citing works
Evidence for the existence of a raphe projection to the substantia nigra in rat
Dray, A., Gonye, T. J., Oakley, N. R., & Tanner, T. (1976) · Brain Research · doi:10.1016/0006-8993(76)90005-6 · Cited by 284 · see citing works
Millan, M. J., Dekeyne, A., & Gobert, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00078-1 · Cited by 283 · see citing works
The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain
Burnet, P. W. J., Eastwood, S. L., Lacey, K., & Harrison, P. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00104-x · Cited by 283 · see citing works
Hall, H., Lundkvist, C., Halldin, C., Farde, L., Pike, V. W., McCarron, J. A., Fletcher, A., Cliffe, I. A., Barf, T. A., Wikström, H., et al. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01131-6 · Cited by 280 · see citing works
Hartig, P. R., Hoyer, D., Humphrey, P. P. A., & Martin, G. R. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)30002-3 · Cited by 280 · see citing works
Taylor, T. N., Caudle, W. M., Shepherd, K. R., Noorian, A. R., Jackson, C. R., Iuvone, P. M., Weinshenker, D., Greene, J. G., & Miller, G. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1495-09.2009 · Cited by 278 · see citing works
Rapport, M. M., Green, A. A., & Page, I. H. (1948) · Science · doi:10.1126/science.108.2804.329 · Cited by 276 · see citing works
Ugedo, L., Grenhoff, J., & Svensson, T. H. (1989) · Psychopharmacology · doi:10.1007/bf00442004 · Cited by 267 · see citing works
Serotonin 2A Receptors and Visual Hallucinations in Parkinson Disease
Ballanger, B., Strafella, A. P., van Eimeren, T., Zurowski, M., Rusjan, P. M., Houle, S., & Fox, S. H. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.35 · Cited by 266 · see citing works
Self-citationLindgren, H. S., Andersson, D. R., Lagerkvist, S., Nissbrandt, H., & Cenci, M. A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06556.x · Cited by 264 · see citing works
Motor effects of serotonin in the central nervous system
Gerson, S. C., & Baldessarini, R. J. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90368-9 · Cited by 263 · see citing works
Maladaptive plasticity of serotonin axon terminals in levodopa‐induced dyskinesia
Ottosson, D. R., Parent, M., O’Sullivan, S. S., Doveró, S., Lees, A. J., Bézard, E., Descarries, L., & Cenci, M. A. (2010) · Annals of Neurology · doi:10.1002/ana.22097 · Cited by 262 · see citing works
Goetz, C. G., Damier, P., Hicking, C., LASKA, E. M., Müller, T. H., Olanow, C. W., Rascol, O., & Russ, H. (2006) · Movement Disorders · doi:10.1002/mds.21226 · Cited by 260 · see citing works
Rabey, J. M., Prokhorov, T., Miniovitz, A., Dobronevsky, E., & Klein, C. (2006) · Movement Disorders · doi:10.1002/mds.21116 · Cited by 259 · see citing works
The 5-HT3receptor as a therapeutic target
Thompson, A. J., & Lummis, S. C. R. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.4.527 · Cited by 258 · see citing works
Parsons, L. H., & Justice, J. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)90984-u · Cited by 253 · see citing works
RS-102221: A Novel High Affinity and Selective, 5-HT 2C Receptor Antagonist
Bonhaus, D. W., Weinhardt, K. K., Taylor, M., DeSouza, A., McNeeley, P. M., Szczepanski, K., Fontana, D., Trinh, J. V., Rocha, C., Dawson, M. W., et al. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00049-x · Cited by 253 · see citing works
Niesler, B., Frank, B., Kapeller, J., & Rappold, G. (2003) · Gene · doi:10.1016/s0378-1119(03)00503-1 · Cited by 252 · see citing works
Neurotransmitter receptor alterations in Parkinson's disease
Reisine, T., Fields, J. Z., Yamamura, H. I., Bird, E. D., SPOKES, E. G. S., Schreiner, P. S., & Enna, S. J. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90514-8 · Cited by 252 · see citing works
Goetz, C. G., Blasucci, L. M., Leurgans, S. E., & Pappert, E. J. (2000) · Neurology · doi:10.1212/wnl.55.6.789 · Cited by 249 · see citing works
Aminergic systems in Alzheimer's disease and Parkinson's disease
D’Amato, R. J., Zweig, R. M., Whitehouse, P. J., Wenk, G. L., Singer, H. S., Mayeux, R. P., Price, D. L., & Snyder, S. H. (1987) · Annals of Neurology · doi:10.1002/ana.410220207 · Cited by 248 · see citing works
Clozapine-induced weight gain: prevalence and clinical relevance
Leadbetter, R. A., Shutty, M. S., Pavalonis, D., Vieweg, V., Higgins, P., & Downs, M. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.1.68 · Cited by 248 · see citing works
Abramowski, D., Rigo, M., Duc, D., Hoyer, D., & Staufenbiel, M. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00138-7 · Cited by 243 · see citing works
van der Kooy, D., & Hattori, T. (1980) · Brain Research · doi:10.1016/0006-8993(80)90250-4 · Cited by 243 · see citing works
Hillarp, N. ‐., Fuxé, K., & Dahlström, A. B. (1966) · PubMed · Cited by 242 · see citing works
Occurrence and Localization of Catechol Amines in the Human Brain
Bertler, Å. (1961) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1961.tb02118.x · Cited by 242 · see citing works
Staging of serotonergic dysfunction in Parkinson's Disease: An in vivo 11C-DASB PET study
Politis, M., Wu, K., Loane, C., Kiferle, L., Molloy, S., Brooks, D. J., & Piccini, P. P. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.028 · Cited by 242 · see citing works
Atlas of the distribution of monoamine‐containing nerve cell bodies in the brain stem of the cat
Poitras, D., & Parent, A. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901790402 · Cited by 242 · see citing works
Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models
Bibbiani, F., Oh, J. D., & Chase, T. N. (2001) · Neurology · doi:10.1212/wnl.57.10.1829 · Cited by 241 · see citing works
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
Muñoz, A., Li, Q., Gardoni, F., Marcello, E. E., Qin, C., Carlsson, T., Kirik, D., Luca, M. D., Björklund, A., Bézard, E., et al. (2008) · Brain · doi:10.1093/brain/awn235 · Cited by 241 · see citing works
15th annual meeting of the society for neuroscience
(1985) · Peptides · doi:10.1016/0196-9781(85)90125-1 · Cited by 240 · see citing works
Mengod, G., Pompeiano, M., ́nez-Mir, M. I. M., & Palacios, J. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90502-3 · Cited by 240 · see citing works
Insights into the Neurobiology of Impulsive Behavior from Serotonin Receptor Knockout Mice
Brunner, D., & Hen, R. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52356.x · Cited by 240 · see citing works
Steininger, T. L., Gong, H., McGinty, D., & Szymusiak, R. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010122)429:4 · Cited by 240 · see citing works
Bernheimer, H., Birkmayer, W., & Hornykiewicz, O. (1961) · Journal of Molecular Medicine · doi:10.1007/bf01487648 · Cited by 240 · see citing works
Kennett, G. A., Wood, M. D., Bright, F., et al. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15208.x · Cited by 240 · see citing works
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A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei
Pollak Dorocic, I., Fürth, D., Xuan, Y., Johansson, Y., Pozzi, L., Silberberg, G., Carlén, M., & Meletis, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.002 · Cited by 451 · see citing works
Molecular and anatomical organization of the dorsal raphe nucleus
Huang, K. W., Ochandarena, N. E., Philson, A. C., Hyun, M., Birnbaum, J. E., Cicconet, M., & Sabatini, B. L. (2019) · eLife · doi:10.7554/elife.46464 · Cited by 267 · see citing works
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Blesa, J., Foffani, G., Dehay, B., Bezard, E., & Obeso, J. A. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00542-9 · Cited by 232 · see citing works
Tong, Q., Zhang, L., Yuan, Y., Jiang, S., Zhang, R., Xu, Q., Ding, J., Li, D., Zhou, X., & Zhang, K. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.05.016 · Cited by 81 · see citing works
- Authors
- Huot, P., Fox, S. H., & Brotchie, J. M.
- Affiliations
- University Health Network (CA)
- Corresponding author
- Brotchie, Jonathan M.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 95
- Issue
- 2
- Pages
- 163-212
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W1970083936
- Cited by
- 195
- References
- 962
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 14 · 2021: 8 · 2020: 10 · 2019: 13 · 2018: 8 · 2017: 14 · 2016: 16 · 2015: 19 · 2014: 19 · 2013: 20 · 2012: 14
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, serotonergic system, serotonin, 5-HT receptor subtypes, non-motor symptoms, treatment complications, dopamine depletion, striatum, animal models
- MeSH terms
- Animals, Disease Models, Animal, Humans, Synaptic Transmission, Parkinson Disease, Receptors, Serotonin, Serotonin, Protein Isoforms, Molecular Targeted Therapy, Serotonergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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