The DOI matches its Crossref record; 92 of the 93 references it cites were found in a registry or an index.
Pharmacological treatments that facilitate extinction of fear: Relevance to psychotherapy
Open accessAbstract
Summary A great deal is now known about the mechanisms of conditioned fear acquisition and expression. More recently, the mechanisms of inhibition of conditioned fear have become the subject of intensive study. The major model system for the study of fear inhibition in the laboratory is extinction, in which a previously fear conditioned organism is exposed repeatedly to the fear-eliciting cue in the absence of any aversive event and the fear conditioned response declines. It is well established that extinction is a form of new learning as opposed to forgetting or "unlearning" of conditioned fear, and it is hypothesized that extinction develops when sensory pathways conveying sensory information to the amygdala come to engage GABAergic interneurons through forms of experience-dependent plasticity such as long-term potentiation. Several laboratories currently are investigating methods of facilitating fear extinction in animals with the hope that such treatments might ultimately prove to be useful in facilitating exposure-based therapy for anxiety disorders in clinical populations. This review discusses the advances that have been made in this field and presents the findings of the first major clinical study to examine the therapeutic utility of a drug that facilitates extinction in animals. It is concluded that extinction is an excellent model system for the study of fear inhibition and an indispensable tool for the screening of putative pharmacotherapies for clinical use.
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“Chemically blocking the receptor shortly before extinction training blocks extinction in animal research, a finding that shows a dose-response relation.”
From Mediators and Mechanisms of Change in Psychotherapy Research (2007) · cites this paper as Davis et al. 2006
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“Blocking the receptor after extinction training also blocks extinction, which suggests that the consolidation process can be interrupted.”
From Mediators and Mechanisms of Change in Psychotherapy Research (2007) · cites this paper as Davis et al. 2006
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“Conditioning and extinction of fear depend on a particular receptor in the amygdala (N-methyl-D-aspartate) (see Davis et al. 2006).”
From Mediators and Mechanisms of Change in Psychotherapy Research (2007) · cites this paper as Davis et al. 2006
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“A compound (D-cycloserine) binds to the receptor and makes the receptor work better, i.e., enhances extinction when given before or soon after extinction training.”
From Mediators and Mechanisms of Change in Psychotherapy Research (2007) · cites this paper as Davis et al. 2006
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Self-citation
Research works printed but not linked: 3
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Mediators and Mechanisms of Change in Psychotherapy Research
Kazdin, A. E. (2007) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091432 · Cited by 2,504
Kazdin, A. E. (2008) · American Psychologist · doi:10.1037/0003-066x.63.3.146 · Cited by 1,112
Understanding how and why psychotherapy leads to change
Kazdin, A. E. (2009) · Psychotherapy Research · doi:10.1080/10503300802448899 · Cited by 728
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
Epstein, D. H., Preston, K. L., Stewart, J., & Shaham, Y. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0529-6 · Cited by 627
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Metadata
- Authors
- Davis, M., Myers, K. M., Chhatwal, J., & Ressler, K. J.
- Affiliations
- Emory University (US)
- Corresponding author
- Davis, Michael
- Venue
- NeuroRX
- Published
- 2006-01
- Volume
- 3
- Issue
- 1
- Pages
- 82-96
- ISSN
- 1545-5343 (ISSN-L)
- PMC
- PMC2919202
- OpenAlex
- W1988011200
- Cited by
- 174
- References
- 93
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 27 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 15 · 2012: 15
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- NeuroRx (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Emory University
- National Institute of Mental Health (MH-047840, MH069884, F30MH070218, MH070218, K01MH069884)
- National Institute of General Medical Sciences (T32GM008169)
- National Center for Research Resources (P51RR000165)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fear extinction, fear conditioning, anxiety disorders, exposure therapy, amygdala, GABAergic interneurons, long-term potentiation, experience-dependent plasticity, fear inhibition
- MeSH terms
- Extinction, Psychological, Fear, Humans, Phobic Disorders, Psychotherapy, Receptors, Glutamate, Excitatory Amino Acid Agonists, Glutamic Acid
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