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Pharmacological treatments that facilitate extinction of fear: Relevance to psychotherapy

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Davis, Michael, Myers, Karyn M., Chhatwal, Jasmeer, Ressler, Kerry J.·2006·NeuroRX

DOI 10.1016/j.nurx.2005.12.008PMC PMC2919202

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Abstract

Summary A great deal is now known about the mechanisms of conditioned fear acquisition and expression. More recently, the mechanisms of inhibition of conditioned fear have become the subject of intensive study. The major model system for the study of fear inhibition in the laboratory is extinction, in which a previously fear conditioned organism is exposed repeatedly to the fear-eliciting cue in the absence of any aversive event and the fear conditioned response declines. It is well established that extinction is a form of new learning as opposed to forgetting or "unlearning" of conditioned fear, and it is hypothesized that extinction develops when sensory pathways conveying sensory information to the amygdala come to engage GABAergic interneurons through forms of experience-dependent plasticity such as long-term potentiation. Several laboratories currently are investigating methods of facilitating fear extinction in animals with the hope that such treatments might ultimately prove to be useful in facilitating exposure-based therapy for anxiety disorders in clinical populations. This review discusses the advances that have been made in this field and presents the findings of the first major clinical study to examine the therapeutic utility of a drug that facilitates extinction in animals. It is concluded that extinction is an excellent model system for the study of fear inhibition and an indispensable tool for the screening of putative pharmacotherapies for clinical use.

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Authors: Davis, M., Myers, K. M., Chhatwal, J., & Ressler, K. J.
Affiliations: Emory University (US)
Corresponding author: Davis, Michael
ORCID: Chhatwal, Jasmeer
Ressler, Kerry J.
Venue: NeuroRX
Publisher: Springer Science and Business Media LLC
Published: 2006-01
Volume: 3
Issue: 1
Pages: 82-96
ISSN: 1545-5343 (ISSN-L)
DOI: 10.1016/j.nurx.2005.12.008
PMC: PMC2919202
OpenAlex: W1988011200
Cited by: 174
References: 93
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 27 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 15 · 2012: 15
FWCI: 1.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: NeuroRx (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Emory University
National Institute of Mental Health (MH-047840, MH069884, F30MH070218, MH070218, K01MH069884)
National Institute of General Medical Sciences (T32GM008169)
National Center for Research Resources (P51RR000165)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: fear extinction, fear conditioning, anxiety disorders, exposure therapy, amygdala, GABAergic interneurons, long-term potentiation, experience-dependent plasticity, fear inhibition
MeSH terms: Extinction, Psychological, Fear, Humans, Phobic Disorders, Psychotherapy, Receptors, Glutamate, Excitatory Amino Acid Agonists, Glutamic Acid

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Pharmacological treatments that facilitate extinction of fear: Relevance to psychotherapy

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