Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome
Open accessAbstract
Objective Green tea (Camellia sinensis) has shown to exert cardioprotective benefits in observational studies. The objective of this clinical trial was to assess the effects of green tea on features of metabolic syndrome and inflammation in obese subjects.Methods We conducted a randomized controlled trial in obese subjects with metabolic syndrome. Thirty-five subjects [(mean ± SE) age 42.5 ± 1.7 y, body mass index 36.1 ± 1.3 kg/m(2)] completed the 8-wk study and were randomly assigned to receive green tea (4 cups/d), green tea extract (2 capsules and 4 cups water/d), or no treatment (4 cups water/d). Both the beverage and extract groups had similar dosing of epigallocatechin-3-gallate, the active green tea polyphenol. Fasting blood samples were collected at screening, 4 and 8 wk of the study.Results Green tea beverage or extract supplementation did not significantly alter features of metabolic syndrome or biomarkers of inflammation including adiponectin, C-reactive protein, interleukin-6, interleukin-1β, soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1, leptin, or leptin:adiponectin ratio. However, both green tea beverage and extracts significantly reduced plasma serum amyloid alpha versus no treatment (P < 0.005).Conclusion This study suggests that the daily consumption of green tea beverage or extracts for 8 wk was well tolerated but did not affect the features of metabolic syndrome. However, green tea significantly reduced plasma serum amyloid alpha, an independent cardiovascular disease risk factor, in obese subjects with metabolic syndrome.
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A larger Japanese study of 778 men and 1404 women reported an inverse association between serum vitamin C and CRP concentrations after adjustment for confounders.
“A larger Japanese study (n 778 men and 1404 women) reported an inverse association between serum vitamin C and CRP concentrations after adjustment for confounders (775) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [775]
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References 82 · Cited by 194
- Authors
- Basu, A., Du, M., Sanchez, K., Leyva, M. J., Betts, N. M., Blevins, S., Wu, M., Aston, C. E., & Lyons, T. J.
- Affiliations
- Oklahoma State University (US)
- University of Oklahoma Health Sciences Center (US)
- Corresponding author
- Basu, Arpita
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 27
- Issue
- 2
- Pages
- 206-213
- ISSN
- 0899-9007 (ISSN-L)
- PMC
- PMC2952043
- OpenAlex
- W2047136790
- Cited by
- 194
- References
- 82
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 10 · 2020: 17 · 2019: 12 · 2018: 8 · 2017: 17 · 2016: 12 · 2015: 16 · 2014: 11 · 2013: 18 · 2012: 13
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- National Center for Research Resources (M01 RR-14467, M01RR014467)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- green tea, metabolic syndrome, obesity, inflammatory markers, serum amyloid A, epigallocatechin gallate, green tea extract, adiponectin, C-reactive protein, interleukin-6, leptin, cardiovascular risk factors
- MeSH terms
- Adult, Antioxidants, C-Reactive Protein, Cardiovascular Diseases, Catechin, Female, Humans, Inflammation, Male, Phytotherapy, Middle Aged, Obesity, Plant Extracts, Tea, Biomarkers, Interleukin-6, Single-Blind Method, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Metabolic Syndrome, Camellia sinensis, Interleukin-1beta
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