Cited by 28Obsessive-Compulsive Spectrum DisordersTrace Elements in HealthSchizophrenia research and treatment

Evaluation of oral zinc sulfate effect on obsessive-compulsive disorder: A randomized placebo-controlled clinical trial

Sayyah, Mehdi, Olapour, Alireza, Saeedabad, Yashar shahhosseini, Yazdan Parast, Rezvan, Malayeri, Alireza·2012·Nutrition

Abstract

Objective Obsessive-compulsive disorder is a common neuropsychiatric condition. Although various pharmaceutical agents are available for the treatment of obsessive-compulsive disorder, psychiatrists often find that many patients cannot tolerate the side effects of these medications, the patients do not respond properly to the treatment, or the medications lose their effectiveness after a period of treatment. The augmentation with safe supplementation of medication, such as with trace elements, may be a solution to some of these problems.Methods This study was a prospective, double-blinded, 8-wk trial. Twelve patients were given fluoxetine (20 mg/d) plus zinc (440 mg/d) and 11 patients were given fluoxetine plus placebo for 8 wk.Results Both groups showed a decrease in the mean Yale-Brown Obsessive-Compulsive Scale score. Based on t tests, in weeks 2 and 8, patients treated with fluoxetine plus zinc had significantly lower scores than those treated with fluoxetine plus placebo.Conclusion The results show that zinc, as adjuvant agent for obsessive-compulsive disorder, produces improved outcomes.

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Crossref · 10.1016/j.nut.2011.11.027

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Authors
Sayyah, M., Olapour, A., Saeedabad, Y. S., Yazdan Parast, R., & Malayeri, A.
Affiliations
  • Ahvaz Jundishapur University of Medical Sciences (IR)
  • Hafez Hospital (IR)
Corresponding author
Sayyah, Mehdi
Venue
Nutrition
Publisher
Elsevier BV
Published
2012-09
Volume
28
Issue
9
Pages
892-895
ISSN
0899-9007 (ISSN-L)
OpenAlex
W2135212984
Cited by
28
References
33
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 6
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
obsessive-compulsive disorder, zinc sulfate, zinc supplementation, fluoxetine, adjuvant therapy, trace elements, Yale-Brown Obsessive Compulsive Scale, treatment-resistant OCD
MeSH terms
Administration, Oral, Adult, Double-Blind Method, Drug Therapy, Combination, Female, Fluoxetine, Humans, Male, Obsessive-Compulsive Disorder, Prospective Studies, Psychiatric Status Rating Scales, Trace Elements, Zinc, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Zinc Sulfate, Dietary Supplements

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