The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Biomarkers of Cardiovascular Disease as Risk Factors for Age-Related Macular Degeneration
Abstract
Purpose To measure and contrast 2 biomarkers of cardiovascular disease, C-reactive protein (CRP) and plasma homocysteine, in individuals with age-related macular degeneration (AMD) and control individuals without AMD.Design Case-control study.Participants Seventy-nine affected individuals and 77 unaffected individuals from the AMD Genetic Study Group returned to obtain CRP and homocysteine levels.Methods Both affected and unaffected individuals underwent testing for CRP and homocysteine. A detailed cardiovascular history was taken.Main outcome measures Mean CRP and homocysteine levels in affected and unaffected individuals.Results Mean CRP levels for affected and unaffected individuals were 3.42 and 2.30 mg/l, respectively (P = 0.03). Mean homocysteine levels for affected and unaffected individuals were 11.72 and 8.88 micromol/l, respectively (P<0.0001). In logistic regression models, older age, higher CRP, and higher homocysteine were risk factors for AMD. There were no significant differences between cases and controls in terms of gender, diabetes, hypertension, use of statin drugs, and smoking. The control group was significantly younger and had a lower rate of vitamin usage than the affected group.Conclusions Elevated CRP and homocysteine levels are associated with AMD and implicate the role of chronic inflammation and atherosclerosis.
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“The association of cardiovascular disease and its risk factors with AMD have not been consistently reproduced (26, 127, 136, 153).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [153]
Citations
Cites
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A role for local inflammation in the formation of drusen in the aging eye
Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087
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Bhutto, I. A., & Lutty, G. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.04.005 · Cited by 1,028
Pennington, K. L., & DeAngelis, M. M. (2016) · Eye and Vision · doi:10.1186/s40662-016-0063-5 · Cited by 499
Risk factors and biomarkers of age-related macular degeneration
Lambert, N. G., Elshelmani, H., Singh, M. K., Mansergh, F. C., Wride, M. A., Padilla, M., Keegan, D., Hogg, R. E., & Ambati, B. K. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.04.003 · Cited by 367
Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians
Wong, C. W., Yanagi, Y., Lee, W., Ogura, Y., Yeo, I. Y. S., Wong, T. Y., & Cheung, C. M. G. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.04.002 · Cited by 345
Swaroop, A., Chew, E. Y., Bowes Rickman, C., & Abecasis, G. R. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164350 · Cited by 270
Self-citation
Metadata
- Authors
- Vine, A. K., Stader, J., Branham, K., Musch, D. C., & Swaroop, A.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Vine, Andrew K.
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 112
- Issue
- 12
- Pages
- 2076-2080
- ISSN
- 0161-6420 (ISSN-L)
- OpenAlex
- W2061671127
- Cited by
- 160
- References
- 54
- Citations by year
- 2026: 3 · 2025: 5 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 15 · 2014: 9 · 2013: 9 · 2012: 15
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related macular degeneration, C-reactive protein, homocysteine, cardiovascular biomarkers, chronic inflammation, atherosclerosis, risk factors
- MeSH terms
- Aged, Aged, 80 and over, C-Reactive Protein, Chromatography, High Pressure Liquid, Female, Fluorescein Angiography, Homocysteine, Humans, Inflammation, Macular Degeneration, Male, Middle Aged, Nephelometry and Turbidimetry, Risk Factors, Biomarkers, Case-Control Studies, Atherosclerosis
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