Prevalence of age-related maculopathy

Klein, Ronald; Klein, Barbara E.K.; Linton, Kathryn L.P.

doi:10.1016/s0161-6420(92)31871-8

Cited by 1,845Retinal Diseases and TreatmentsRetinal Imaging and AnalysisOcular Diseases and Behçet’s Syndrome

Prevalence of age-related maculopathy

Klein, Ronald, Klein, Barbara E.K., Linton, Kathryn L.P.·1992·Ophthalmology

DOI 10.1016/s0161-6420(92)31871-8

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Abstract

Purpose The relationships of retinal drusen, retinal pigmentary abnormalities, and macular degeneration to age and sex were studied in 4926 people between the ages of 43 and 86 years who participated in the Beaver Dam Eye Study.Methods The presence and severity of various characteristics of drusen and other lesions typical of age-related maculopathy were determined by grading stereoscopic color fundus photographs using the Wisconsin Age-Related Maculopathy Grading System.Results One or more drusen were present in the macular area of at least 1 eye in 95.5% of the population. People 75 years of age or older had significantly higher frequencies (P less than 0.01) of the following characteristics than people 43 to 54 years of age: larger sized drusen (greater than or equal to 125 microns, 24.0% versus 1.9%), soft indistinct drusen (23.0% versus 2.1%), retinal pigment abnormalities (26.6% versus 7.3%), exudative macular degeneration (5.2% versus 0.1%), and geographic atrophy (2.0% versus 0%).Conclusion These data indicate signs of age-related maculopathy are common in people 75 years of age or older and may pose a substantial public health problem.

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For Americans older than age 70, approximately 80% fall in the low-risk groups (Categories 1 or 2).
“For Americans older than age 70, approximately 80% fall in these low-risk groups.37”
From A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8 (2001) · cites this paper as [37]
Age is the strongest risk factor for age-related macular degeneration; all population-based studies confirm that the prevalence of age-related macular degeneration increases with age in white individuals.
“Age is the strongest risk factor for age-related macular degeneration; all population-based studies confirm that the prevalence of age-related macular degeneration increases with age in white individuals.3,22–27”
From Age-related macular degeneration (2008) · cites this paper as [23]

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Authors: Klein, R., Klein, B. E. K., & Linton, K. L. P.
Affiliations: University of Wisconsin–Madison (US)
Venue: Ophthalmology
Publisher: Elsevier BV
Published: 1992-06
Volume: 99
Issue: 6
Pages: 933-943
ISSN: 0161-6420 (ISSN-L)
DOI: 10.1016/s0161-6420(92)31871-8
OpenAlex: W180812339
Cited by: 1,845
References: 28
Citations by year: 2026: 12 · 2025: 23 · 2024: 30 · 2023: 38 · 2022: 37 · 2021: 56 · 2020: 46 · 2019: 43 · 2018: 41 · 2017: 62 · 2016: 42 · 2015: 65 · 2014: 56 · 2013: 83 · 2012: 77
FWCI: 27.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (EY O6594, U10EY006594)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: age-related maculopathy, retinal drusen, neovascular age-related macular degeneration, geographic atrophy, macular degeneration, prevalence, age differences, sex differences, Beaver Dam Eye Study
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Macula Lutea, Macular Degeneration, Male, Middle Aged, Retinitis Pigmentosa, Risk Factors, Wisconsin, Retinal Drusen, Prevalence

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