The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Mucositis: The impact, biology and therapeutic opportunities of oral mucositis
Abstract
The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinicians, no effective treatment existed. Fortunately, the situation is changing; ongoing research is leading to a comprehensive understanding of the biology of mucositis, which has resulted in the development of novel interventions. While the FDA's approval of palifermin in 2004 was limited to only a small percentage of the at-risk population, the fact that the first registered anti-OM agent derived its efficacy from its pleotropic activities was conceptually demonstrative of the therapeutic potential of drugs that selectively interfere with mucositis' pathogenesis. A number of eclectic molecules, all designed to interfere with pathways that lead to injury are in pre-clinical and clinical development.
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“reactive oxygen species (ROS) can mediate the deleterious effects of radiation and contribute to DNA damage and the activation of senescence pathways in cells (Diehn et al., 2009; Kuilman et al., 2010; Sonis, 2009; Spitz et al., 2004).”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009
In the citing paper
“suggesting that mTOR inhibition might also ameliorative mucositis by preventing the release of a pro-senescent and pro-inflammatory secretome from normal and irradiated cells (Sonis, 2009)”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009
In the citing paper
“The generation of ROS is also an important mediator of the cellular alterations caused by radiation exposure (Diehn et al., 2009; Sonis, 2009; Spitz et al., 2004), including mucositis (Citrin et al., 2010; Cotrim et al., 2007; Cotrim et al., 2005).”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009
Citations
Cites
Moore, M. J., Goldstein, D., Hamm, J., Figer, A., Hecht, J. R., Gallinger, S., Au, H. J., Murawa, P., Walde, D., Wolff, R. A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.9525 · Cited by 3,848
Sonis, S. T. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1318 · Cited by 1,376
Palifermin for Oral Mucositis after Intensive Therapy for Hematologic Cancers
Spielberger, R. T., Stiff, P. J., Bensinger, W., Gentile, T., Weisdorf, D. J., Kewalramani, T., Shea, T. C., Yanovich, S., Hansen, K. S., Noga, S. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040125 · Cited by 891
Oral Mucositis and the Clinical and Economic Outcomes of Hematopoietic Stem-Cell Transplantation
Sonis, S. T., Oster, G., Fuchs, H., Bellm, L. A., Bradford, W. Z., Edelsberg, J., Hayden, V., Eilers, J., Epstein, J. B., LeVeque, F. G., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.8.2201 · Cited by 679
Sonis, S. T. (1998) · Oral Oncology · doi:10.1016/s1368-8375(97)00053-5 · Cited by 569
Cancer-associated fibroblasts and tumor growth – bystanders turning into key players
Östman, A., & Augsten, M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.01.003 · Cited by 555
Schwab, M. G., Zanger, U. M., Marx, C., Schaeffeler, E., Klein, K., Dippon, J., Kerb, R., Blievernicht, J. K., Fischer, J. E., Hofmann, U., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2006.10.4182 · Cited by 393
Elting, L. S., Keefe, D. M. K., Sonis, S. T., Garden, A. S., Spijkervet, F. K. L., Barasch, A., Tishler, R. B., Canty, T. P., Kudrimoti, M. R., & Vera‐Llonch, M. (2008) · Cancer · doi:10.1002/cncr.23898 · Cited by 372
Pathobiology of oral mucositis: novel insights and opportunities.
Sonis, S. T. (2007) · PubMed · Cited by 302
Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions
Barasch, A., & Peterson, D. E. (2003) · Oral Oncology · doi:10.1016/s1368-8375(02)00033-7 · Cited by 243
Research works printed but not linked: 4
- Grunberg, 2007, Risk, quality of life impact of mucosal injury among colorectal cancer patients receiving FOLFOX chemotherapy, Support Care Cancer, 15, 704
- Chen E. Impact of pre-existing psoriasis and Addison’s disease on chemotherapy-induced mucositis in patients with hematological maliganancies. Pre-doctoral thesis, Harvard School of Dental Medicine; 2004.
- Bose, 2008, Dysregulation in immune functions by peripheral blood mononuclear cells from head, neck squamous cell carcinoma patients, Cancer Immunol, 8, 10
- Aspinall, 2006, SCV-07, Curr Opin Invest Drugs, 7, 180
Cited by
Sorted by citations
Radiation-Induced Oral Mucositis
Maria, O. M., Eliopoulos, N., & Muanza, T. M. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00089 · Cited by 467
Iglesias-Bartolome, R., Patel, V., Cotrim, A., Leelahavanichkul, K., Molinolo, A. A., Mitchell, J. B., & Gutkind, J. S. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.06.007 · Cited by 284
Villa, A., & Sonis, S. T. (2015) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000180 · Cited by 278
Emerging evidence on the pathobiology of mucositis
Al‐Dasooqi, N., Sonis, S. T., Bowen, J. M., Bateman, E. H., Blijlevens, N. M. A., Gibson, R. J., Logan, R. M., NAIR, R. G., Stringer, A. M., Yazbeck, R., et al. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1900-x · Cited by 241
Elad, S., Yarom, N., Zadik, Y., Kuten‐Shorrer, M., & Sonis, S. T. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21704 · Cited by 240
Metadata
- Authors
- Sonis, S. T.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Sonis, Stephen T.
- ORCID
- Sonis, Stephen T.
- Venue
- Oral Oncology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 45
- Issue
- 12
- Pages
- 1015-1020
- ISSN
- 1368-8375 (ISSN-L)
- OpenAlex
- W2145063848
- Cited by
- 525
- References
- 42
- Citations by year
- 2026: 22 · 2025: 37 · 2024: 39 · 2023: 34 · 2022: 35 · 2021: 52 · 2020: 35 · 2019: 30 · 2018: 24 · 2017: 31 · 2016: 28 · 2015: 33 · 2014: 35 · 2013: 30 · 2012: 24
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › General Dentistry › Oral health in cancer treatment
- Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
- Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
- Keywords
- oral mucositis, radiation-induced mucositis, chemotherapy-induced mucositis, palifermin, mucositis treatment, cancer treatment side effects, preclinical drug development
- MeSH terms
- Animals, Drug Therapy, Female, Cricetinae, Head and Neck Neoplasms, Humans, Male, Mouth Mucosa, Radiotherapy, Risk Factors, Stomatitis, Drug-Related Side Effects and Adverse Reactions
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