Cited by 525Oral health in cancer treatmentChemotherapy-related skin toxicityOral Health Pathology and Treatment

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Mucositis: The impact, biology and therapeutic opportunities of oral mucositis

Sonis, Stephen T.·2009·Oral Oncology

DOI 10.1016/j.oraloncology.2009.08.006

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Abstract

The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinicians, no effective treatment existed. Fortunately, the situation is changing; ongoing research is leading to a comprehensive understanding of the biology of mucositis, which has resulted in the development of novel interventions. While the FDA's approval of palifermin in 2004 was limited to only a small percentage of the at-risk population, the fact that the first registered anti-OM agent derived its efficacy from its pleotropic activities was conceptually demonstrative of the therapeutic potential of drugs that selectively interfere with mucositis' pathogenesis. A number of eclectic molecules, all designed to interfere with pathways that lead to injury are in pre-clinical and clinical development.

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Authors: Sonis, S. T.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Sonis, Stephen T.
ORCID: Sonis, Stephen T.
Venue: Oral Oncology
Publisher: Elsevier BV
Published: 2009-12
Volume: 45
Issue: 12
Pages: 1015-1020
ISSN: 1368-8375 (ISSN-L)
DOI: 10.1016/j.oraloncology.2009.08.006
OpenAlex: W2145063848
Cited by: 525
References: 42
Citations by year: 2026: 22 · 2025: 37 · 2024: 39 · 2023: 34 · 2022: 35 · 2021: 52 · 2020: 35 · 2019: 30 · 2018: 24 · 2017: 31 · 2016: 28 · 2015: 33 · 2014: 35 · 2013: 30 · 2012: 24
FWCI: 2.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Oral Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › General Dentistry › Oral health in cancer treatment
Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Keywords: oral mucositis, radiation-induced mucositis, chemotherapy-induced mucositis, palifermin, mucositis treatment, cancer treatment side effects, preclinical drug development
MeSH terms: Animals, Drug Therapy, Female, Cricetinae, Head and Neck Neoplasms, Humans, Male, Mouth Mucosa, Radiotherapy, Risk Factors, Stomatitis, Drug-Related Side Effects and Adverse Reactions

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Mucositis: The impact, biology and therapeutic opportunities of oral mucositis

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