The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients
Abstract
Previous experiments found that placebos produced small decreases in neural activity of pain-related areas of the brain, yet decreases were only statistically significant after termination of stimuli and in proximity to when subjects rated them. These changes could reflect report bias rather than analgesia. This functional magnetic resonance imaging (fMRI) study examined whether placebo analgesia is accompanied by reductions in neural activity in pain-related areas of the brain during the time of stimulation. Brain activity of irritable bowel syndrome patients was measured in response to rectal distension by a balloon barostat. Large reductions in pain and in brain activation within pain-related regions (thalamus, somatosensory cortices, insula, and anterior cingulate cortex) occurred during the placebo condition. Results indicate that decreases in activity were related to placebo suggestion and a second factor (habituation/attention/conditioning). Although many factors influence placebo analgesia, it is accompanied by reduction in pain processing within the brain in clinically relevant conditions.
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Cites
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Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
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Is the Placebo Powerless?: An Analysis of Clinical Trials Comparing Placebo with No Treatment
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Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
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Altered rectal perception is a biological marker of patients with irritable bowel syndrome
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Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
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Central nervous system mechanisms of analgesia
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Cited by
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843
Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation
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“For example, hypnosis (Faymonville et al., 2000; Rainville et al., 1997) and placebo treatments (Lieberman et al., 2004; Price et al., 2007; Wager et al., 2004b) that lead to reduced pain have consistently reduced rdACC activity.”
A Comprehensive Review of the Placebo Effect: Recent Advances and Current Thought
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Self-citationThe mechanisms of manual therapy in the treatment of musculoskeletal pain: A comprehensive model
Bialosky, J. E., Bishop, M. D., Price, D. D., Robinson, M. E., & George, S. Z. (2009) · Manual Therapy · doi:10.1016/j.math.2008.09.001 · Cited by 1,114
Self-citationActivation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839
Metadata
- Authors
- Price, D. D., Craggs, J., Nicholas Verne, G., Perlstein, W. M., & Robinson, M. E.
- Venue
- Pain
- Published
- 2007-01
- Volume
- 127
- Issue
- 1
- Pages
- 63-72
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2046251010
- Cited by
- 273
- References
- 35
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- closed
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