The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
Abstract
The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. We examined the function of the opioid system and μ-opioid receptors in the brains of healthy human subjects undergoing sustained pain. Sustained pain induced the regional release of endogenous opioids interacting with μ-opioid receptors in a number of cortical and subcortical brain regions. The activation of the μ-opioid receptor system was associated with reductions in the sensory and affective ratings of the pain experience, with distinct neuroanatomical involvements. These data demonstrate the central role of the μ-opioid receptors and their endogenous ligands in the regulation of sensory and affective components of the pain experience.
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Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092
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Selective Opiate Modulation of Nociceptive Processing in the Human Brain
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Cited by
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Self-citationCognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076
The epidemiology and impact of pain in osteoarthritis
Neogi, T. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.03.018 · Cited by 1,730
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
A new look at social support: A theoretical perspective on thriving through relationships
Feeney, B. C., & Collins, N. L. (2015) · Personality and Social Psychology Review · doi:10.1177/1088868314544222 · Cited by 1,521
Metadata
- Authors
- Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S.
- Venue
- Science
- Published
- 2001-07-13
- Volume
- 293
- Issue
- 5528
- Pages
- 311-315
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2157737392
- Cited by
- 841
- References
- 5
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S. (2001). Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain. Science. https://doi.org/10.1126/science.1060952
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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