The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Factors contributing to large analgesic effects in placebo mechanism studies conducted between 2002 and 2007
Abstract
Recent meta-analyses find various magnitudes of placebo analgesia effects in placebo mechanism trials versus placebo control trials, which have led to debate. To further investigate the magnitude of placebo analgesia in placebo mechanism trials the databases "PubMed", "PsycINFO" and "Web of Science" (2002-2007) were searched with the term "placebo analgesia". Twenty-one articles including 24 studies fulfilled the selection criteria (concerning: mechanisms, control, placebo treatment, randomization and pain measures). The validity of studies was assessed by the authors and effect sizes were calculated via difference scores. The magnitude of placebo analgesia in placebo mechanism studies was large (d=1.00) and about five times larger than placebo analgesia effects in placebo control studies (d=0.15-0.27). Differences in magnitude between the two types of studies appear to result from different types of suggestions given for pain relief. The magnitude of placebo effects was larger in studies that used long-term pain stimuli >20s (d=0.96) as opposed to short-term stimuli (d=0.81) and the largest placebo effects were found in studies wherein hyperalgesia was present (d=1.88). These results replicate our previous finding that placebo analgesic effects are higher in mechanism studies than in placebo control studies. However, since magnitudes of placebo analgesic effects are highly variable it may be valuable to investigate the factors and mechanisms that contribute to this variability as well as differences in magnitudes across types of studies.
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Cites
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Self-citationComponents of placebo effect: randomised controlled trial in patients with irritable bowel syndrome
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“The influence of the suggestions given for pain relief has also been demonstrated in patients in the context of actual clinical treatments [2,22,30].”
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Self-citationTHE MECHANISM OF PLACEBO ANALGESIA
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Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
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Placebo effects on human μ-opioid activity during pain
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Cited by
The neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844
Bingel, U., Wanigasekera, V., Wiech, K., Ni Mhuircheartaigh, R., Lee, M. C., Ploner, M., & Tracey, I. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001244 · Cited by 810
(2020) · doi:10.1056/nejmra1907805 · Cited by 634
Placebo Analgesia: A Predictive Coding Perspective
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Metadata
- Authors
- Vase, L., Petersen, G. L., Riley, J. L., & Price, D. D.
- Venue
- Pain
- Published
- 2009-09
- Volume
- 145
- Issue
- 1
- Pages
- 36-44
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2085249681
- Cited by
- 189
- References
- 18
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
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