Predicting Individual Differences in Placebo Analgesia: Contributions of Brain Activity during Anticipation and Pain Experience
Open accessAbstract
Recent studies have identified brain correlates of placebo analgesia, but none have assessed how accurately patterns of brain activity can predict individual differences in placebo responses. We reanalyzed data from two fMRI studies of placebo analgesia (N= 47), using patterns of fMRI activity during the anticipation and experience of pain to predict new subjects' scores on placebo analgesia and placebo-induced changes in pain processing. We used a cross-validated regression procedure, LASSO-PCR, which provided both unbiased estimates of predictive accuracy and interpretable maps of which regions are most important for prediction. Increased anticipatory activity in a frontoparietal network and decreases in a posterior insular/temporal network predicted placebo analgesia. Patterns of anticipatory activity across the cortex predicted a moderate amount of variance in the placebo response (∼12% overall, ∼40% for study 2 alone), which is substantial considering the multiple likely contributing factors. The most predictive regions were those associated with emotional appraisal, rather than cognitive control or pain processing. During pain, decreases in limbic and paralimbic regions most strongly predicted placebo analgesia. Responses within canonical pain-processing regions explained significant variance in placebo analgesia, but the pattern of effects was inconsistent with widespread decreases in nociceptive processing. Together, the findings suggest that engagement of emotional appraisal circuits drives individual variation in placebo analgesia, rather than early suppression of nociceptive processing. This approach provides a framework that will allow prediction accuracy to increase as new studies provide more precise information for future predictive models.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cognitive pain relief correlates with lower pain-related activation in SI, SII, posterior insula, and parietal operculum, alongside higher activation in ACC, PFC, and insula.
“Pain relief produced by these cognitive techniques are associated with significant reductions in pain-related brain activation (i.e., SI, SII, posterior insula, parietal operculum) and activation in higher-order brain regions, such as the ACC, PFC, and insula.86, 89, 98–110”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [103]
A recent study found that vmPFC activity was correlated with the strength of both expectations of analgesia and pain relief.
“and a recent study found that vmPFC activity was correlated with the strength of both expectations of analgesia and pain relief [62].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [62]
Placebo studies often involve conditioning procedures that may serve primarily to alter expectations and the meaning of pain in context.
“While placebo studies often involve conditioning procedures, these may often serve primarily to alter expectations and the meaning of pain in context [60,61], and a recent study found that vmPFC activity was correlated with the strength of both expectations of analgesia and pain relief [62].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regression shrinkage and selection via the lasso
Tibshirani, R. (1996) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1996.tb02080.x · Cited by 51,482 · see citing works
The Elements of Statistical Learning
Hastie, T., Tibshirani, R., & Friedman, J. (2009) · Springer Series in Statistics · doi:10.1007/978-0-387-84858-7 · Cited by 25,970 · see citing works
A Study of Cross-Validation and Bootstrap for Accuracy Estimation and Model Selection
Kohavi, R. (1995) · Zenodo · doi:10.5281/zenodo.19712698 · Cited by 10,909 · see citing works
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336 · see citing works
Distributed and overlapping representations of faces and objects in ventral temporal cortex
Haxby, J. V., Gobbini, M. I., Furey, M. L., Ishai, A., Schouten, J. L., & Pietrini, P. (2001) · Science · doi:10.1126/science.1063736 · Cited by 3,940 · see citing works
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629 · see citing works
(2013) · Springer eBooks · Cited by 2,625 · see citing works
Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050045 · Cited by 2,442 · see citing works
Reliability of the Visual Analog Scale for Measurement of Acute Pain
Bijur, P. E., Silver, W. G., & Gallagher, E. J. (2001) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2001.tb01132.x · Cited by 2,091 · see citing works
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992 · see citing works
Self-citationNeuroimaging studies of working memory:
Wager, T. D., & Smith, E. E. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.4.255 · Cited by 1,889 · see citing works
Self-citationBeecher, H. K. (1955) · JAMA · doi:10.1001/jama.1955.02960340022006 · Cited by 1,850 · see citing works
Linear Model Selection by Cross-validation
Shao, J. (1993) · Journal of the American Statistical Association · doi:10.1080/01621459.1993.10476299 · Cited by 1,790 · see citing works
Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation
Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., & Ochsner, K. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.006 · Cited by 1,761 · cited 4× · see citing works
“Cluster analysis on the correlations among significant regions (Wager et al., 2007b, 2008) revealed that they were organized into a best-guess estimate of five networks (permutation test p 0.001, compared with the null hypothesis of no functional grouping).”
BackgroundMethodInfluentialSelf-citationPlacebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488 · see citing works
Puzzlingly High Correlations in fMRI Studies of Emotion, Personality, and Social Cognition
Vul, E., Harris, C., Winkielman, P., & Pashler, H. (2009) · Perspectives on Psychological Science · doi:10.1111/j.1745-6924.2009.01125.x · Cited by 1,475 · cited 3× · see citing works
“This analysis uses a standard regression approach that is appropriate for inference, but provides biased estimates of effect sizes (Vul et al., 2009; Yarkoni, 2009; Kriegeskorte et al., 2010).”
BackgroundMethodThe elements of statistical learning: Data mining, inference, and prediction
Franklin, J. (2005) · The Mathematical Intelligencer · doi:10.1007/bf02985802 · Cited by 1,400 · see citing works
Predicting Human Brain Activity Associated with the Meanings of Nouns
Mitchell, T. M., Shinkareva, S. V., Carlson, A., Chang, K.-M., Malave, V. L., Mason, R. A., & Just, M. A. (2008) · Science · doi:10.1126/science.1152876 · Cited by 1,180 · see citing works
Kober, H., Barrett, L. F., Joseph, J., Bliss-Moreau, E., Lindquist, K., & Wager, T. D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.059 · Cited by 1,144 · cited 3× · see citing works
“However, only consensus regions involved in emotional appraisal [as identified by meta-analysis (Kober et al., 2008)] were found to predict placebo Figure 8.”
BackgroundMethodSelf-citationChapman, C. R., Casey, K. L., Dubner, R. A., Foley, K. M., Gracely, R. H., & Reading, A. E. (1985) · Pain · doi:10.1016/0304-3959(85)90145-9 · Cited by 1,095 · see citing works
Pain intensity processing within the human brain: a bilateral, distributed mechanism
Coghill, R. C., Sang, C. N., Maisog, J. M., & Iadarola, M. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1934 · Cited by 1,077 · see citing works
Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease
de la Fuente‐Fernández, R., Ruth, T. J., Sossi, V., Schulzer, M., Calne, D. B., & Stoessl, A. J. (2001) · Science · doi:10.1126/science.1060937 · Cited by 991 · see citing works
Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899 · see citing works
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839 · see citing works
Large-Scale Bayesian Logistic Regression for Text Categorization
Genkin, A., Lewis, D. D., & Madigan, D. (2007) · Technometrics · doi:10.1198/004017007000000245 · Cited by 812 · see citing works
Benedetti, F., Pollo, A., Lopiano, L., Lanotte, M., Vighetti, S., & Rainero, I. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04315.2003 · Cited by 788 · see citing works
Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Zubieta, J.-K., Bueller, J. A., Jackson, L. R., Scott, D. J., Xu, Y., Koeppe, R. A., Nichols, T. E., & Stohler, C. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0439-05.2005 · Cited by 779 · see citing works
Neurobiological Mechanisms of the Placebo Effect
Benedetti, F., Mayberg, H., Wager, T., Stohler, C., & Zubieta, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3458-05.2005 · Cited by 771 · see citing works
Self-citationThe subjective experience of pain: where expectations become reality
Koyama, T., McHaffie, J. G., Laurienti, P. J., & Coghill, R. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408576102 · Cited by 747 · see citing works
Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses
Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.34 · Cited by 637 · see citing works
Book Review: Pattern Recognition and Machine Learning
Nasrabadi, N. M. (2007) · Journal of Electronic Imaging · doi:10.1117/1.2819119 · Cited by 636 · see citing works
The influence of negative emotions on pain: Behavioral effects and neural mechanisms
Wiech, K., & Tracey, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.059 · Cited by 614 · see citing works
Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network
Bingel, U., Lorenz, J., Schoell, E., Weiller, C., & Büchel, C. (2006) · Pain · doi:10.1016/j.pain.2005.08.027 · Cited by 567 · see citing works
Placebo effects on human μ-opioid activity during pain
Wager, T. D., Scott, D. J., & Zubieta, J.-K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702413104 · Cited by 562 · see citing works
Self-citationYarkoni, T. (2009) · Perspectives on Psychological Science · doi:10.1111/j.1745-6924.2009.01127.x · Cited by 549 · see citing works
Baseline brain activity fluctuations predict somatosensory perception in humans
Boly, M., Balteau, E., Schnakers, C., Degueldre, C., Moonen, G., Luxen, A., Phillips, C., Peigneux, P., Maquet, P., & Laureys, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611404104 · Cited by 529 · see citing works
Direct evidence for spinal cord involvement in placebo analgesia
Eippert, F., Finsterbusch, J., Bingel, U., & Büchel, C. (2009) · Science · doi:10.1126/science.1180142 · Cited by 512 · see citing works
Does anticipation of pain affect cortical nociceptive systems?
Porro, C. A., Baraldi, P., Pagnoni, G., Serafini, M., Facchin, P., Maieron, M., & Nichelli, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03206.2002 · Cited by 469 · see citing works
Individual differences in reward responding explain placebo-induced expectations and effects
Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.028 · Cited by 466 · see citing works
How prior experience shapes placebo analgesia
Colloca, L., & Benedetti, F. (2006) · Pain · doi:10.1016/j.pain.2006.04.005 · Cited by 443 · see citing works
Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., Carlsson, K., & Ingvar, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.023 · Cited by 437 · cited 1× · see citing works
“Several studies show placebo-induced increases during pain (Petrovic et al., 2002; Bingel et al., 2006; Eippert et al., 2009a) and emotional stimulus processing (Petrovic et al., 2005), and relative increases with low pain expectancy that mediate reduced pain report (Atlas et al., 2010).”
BackgroundMeta-analysis of functional neuroimaging data: current and future directions
Wager, T. D., Lindquist, M., & Kaplan, L. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm015 · Cited by 434 · see citing works
Self-citationBrain mediators of cardiovascular responses to social threat
Wager, T. D., Waugh, C. E., Lindquist, M., Noll, D. C., Fredrickson, B. L., & Taylor, S. F. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.043 · Cited by 402 · see citing works
Self-citationSensory-affective relationships among different types of clinical and experimental pain
Price, D. D., Harkins, S. W., & Baker, C. (1987) · Pain · doi:10.1016/0304-3959(87)90065-0 · Cited by 396 · see citing works
Kong, J., Gollub, R. L., Rosman, I. S., Webb, J. M., Vangel, M. G., Kirsch, I., & Kaptchuk, T. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3556-05.2006 · Cited by 395 · see citing works
Franklin, J. S. (2005) · The Mathematical Intelligencer · Cited by 392 · see citing works
Brain mediators of predictive cue effects on perceived pain
Atlas, L. Y., Bolger, N., Lindquist, M. A., & Wager, T. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0057-10.2010 · Cited by 389 · see citing works
Self-citationVase, L., Robinson, M. E., Verne, N. G., & Price, D. D. (2003) · Pain · doi:10.1016/s0304-3959(03)00073-3 · Cited by 373 · see citing works
Effects of attention on the intensity and unpleasantness of thermal pain
Miron, D., Duncan, G. H., & Bushnell, C. M. (1989) · Pain · doi:10.1016/0304-3959(89)90048-1 · Cited by 364 · see citing works
Keltner, J. R., Furst, A., Fan, C., Redfern, R., Inglis, B., & Fields, H. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4463-05.2006 · Cited by 346 · see citing works
Linear Model Selection by Cross-Validation
Shao, J. (1993) · Journal of the American Statistical Association · doi:10.2307/2290328 · Cited by 327 · see citing works
Effects of Expectation on Placebo-Induced Dopamine Release in Parkinson Disease
Lidstone, S. C., Schulzer, M., Dinelle, K., Mak, E., Sossi, V., Ruth, T. J., de la Fuente‐Fernández, R., Phillips, A. G., & Stoessl, A. J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.88 · Cited by 325 · see citing works
Benedetti, F., Colloca, L., Torre, E., Lanotte, M., Melcarne, A., Pesare, M., Bergamasco, B., & Lopiano, L. (2004) · Nature Neuroscience · doi:10.1038/nn1250 · Cited by 303 · see citing works
How the number of learning trials affects placebo and nocebo responses
Colloca, L., Petrovic, P., Wager, T. D., Ingvar, M., & Benedetti, F. (2010) · Pain · doi:10.1016/j.pain.2010.08.007 · Cited by 300 · see citing works
Self-citationPrestimulus functional connectivity determines pain perception in humans
Ploner, M., Lee, M., Wiech, K., Bingel, U., & Tracey, I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906186106 · Cited by 297 · see citing works
The neural correlates of placebo effects: a disruption account
Lieberman, M. D., Jarcho, J. M., Berman, S. M., Naliboff, B. D., Suyenobu, B. Y., Mandelkern, M. A., & Mayer, E. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.037 · Cited by 288 · see citing works
Price, D. D., Craggs, J. G., Verne, G. N., Perlstein, W. M., & Robinson, M. E. (2006) · Pain · doi:10.1016/j.pain.2006.08.001 · Cited by 271 · see citing works
Neurobiological Substrates of Dread
Berns, G. S., Chappelow, J., Cekic, M. M., Zink, C. F., Pagnoni, G., & Martin-Skurski, M. E. (2006) · Science · doi:10.1126/science.1123721 · Cited by 270 · see citing works
Wager, T. D., van Ast, V. A., Hughes, B. L., Davidson, M. L., Lindquist, M. A., & Ochsner, K. N. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.044 · Cited by 264 · see citing works
Self-citationDe Pascalis, V., Chiaradia, C., & Carotenuto, E. (2002) · Pain · doi:10.1016/s0304-3959(01)00485-7 · Cited by 249 · see citing works
Performance-dependent inhibition of pain by an executive working memory task
Buhle, J., & Wager, T. D. (2010) · Pain · doi:10.1016/j.pain.2009.10.027 · Cited by 249 · see citing works
Self-citationDistribution-balanced stratified cross-validation for accuracy estimation
Zeng, X., & Martinez, T. R. (2000) · Journal of Experimental & Theoretical Artificial Intelligence · doi:10.1080/095281300146272 · Cited by 240 · see citing works
Gracely, R. H., Dubner, R. A., & McGrath, P. A. (1979) · Science · doi:10.1126/science.424753 · Cited by 228 · see citing works
Geers, A. L., Helfer, S. G., Kosbab, K., Weiland, P. E., & Landry, S. J. (2005) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.08.011 · Cited by 225 · see citing works
Brown, C. A., Seymour, B., Boyle, Y., El-Deredy, W., & Jones, A. K. P. (2008) · Pain · doi:10.1016/j.pain.2007.05.022 · Cited by 218 · see citing works
Everything You Never Wanted to Know about Circular Analysis, but Were Afraid to Ask
Kriegeskorte, N., Lindquist, M. A., Nichols, T. E., Poldrack, R. A., & Vul, E. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.86 · Cited by 214 · see citing works
Schweinhardt, P., Seminowicz, D. A., Jaeger, E., Duncan, G. H., & Bushnell, M. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5634-08.2009 · Cited by 210 · see citing works
Reproducibility of placebo analgesia: Effect of dispositional optimism
Morton, D. L., Watson, A., El-Deredy, W., & Jones, A. K. P. (2009) · Pain · doi:10.1016/j.pain.2009.07.026 · Cited by 190 · see citing works
Vase, L., Petersen, G. L., Riley, J. L., & Price, D. D. (2009) · Pain · doi:10.1016/j.pain.2009.04.008 · Cited by 186 · see citing works
Watson, A., El‐Deredy, W., Iannetti, G. D., Lloyd, D. M., Tracey, I., Vogt, B. A., Nadeau, V. J., & Jones, A. K. P. (2009) · Pain · doi:10.1016/j.pain.2009.04.003 · Cited by 182 · see citing works
Learning potentiates neurophysiological and behavioral placebo analgesic responses
Colloca, L., Tinazzi, M., Recchia, S., Le Pera, D., Fiaschi, A., Benedetti, F., & Valeriani, M. (2008) · Pain · doi:10.1016/j.pain.2008.04.021 · Cited by 180 · see citing works
Clark, C. W., Yang, J., Tsui, S.-L., Ng, K. F. J., & Clark, S. B. (2002) · Pain · doi:10.1016/s0304-3959(01)00474-2 · Cited by 162 · see citing works
Functional activity mapping of the mesial hemispheric wall during anticipation of pain
Porro, C. A., Cettolo, V., Francescato, M. P., & Baraldi, P. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00184-8 · Cited by 150 · see citing works
Sneed, J. R., Rutherford, B. R., Rindskopf, D., Lane, D. T., Sackeim, H. A., & Roose, S. P. (2008) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181256b1d · Cited by 140 · see citing works
Price, D. D., Barrell, J. J., & Gracely, R. H. (1980) · Pain · doi:10.1016/0304-3959(88)90001-2 · Cited by 138 · see citing works
Lorenz, J., Hauck, M., Paur, R. C., Nakamura, Y., Zimmermann, R., Bromm, B., & Engel, A. K. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.03.010 · Cited by 137 · see citing works
Correlations in Social Neuroscience Aren't Voodoo: Commentary on Vul et al. (2009)
Lieberman, M. D., Berkman, E. T., & Wager, T. D. (2009) · Perspectives on Psychological Science · doi:10.1111/j.1745-6924.2009.01128.x · Cited by 135 · see citing works
Self-citationPlacebo-Induced Changes in Spinal Cord Pain Processing
Matre, D., Casey, K. L., & Knardahl, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4218-05.2006 · Cited by 134 · see citing works
Hua, L. H., Strigo, I. A., Baxter, L. C., Johnson, S. C., & Craig, A. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00123.2005 · Cited by 134 · see citing works
Moulton, E. A., Keaser, M. L., Gullapalli, R. P., & Greenspan, J. D. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01025.2004 · Cited by 129 · see citing works
Regional frontal injuries cause distinct impairments in cognitive control
ALEXANDER, M. P., Stuss, D. T., Picton, T. W., Shallice, T., & Gillingham, S. M. (2007) · Neurology · doi:10.1212/01.wnl.0000261482.99569.fb · Cited by 124 · see citing works
Belief or Need? Accounting for individual variations in the neurochemistry of the placebo effect
Zubieta, J.-K., Yau, W. W., Scott, D., & Stohler, C. S. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.08.006 · Cited by 112 · see citing works
Aslaksen, P., & Flaten, M. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31818105ed · Cited by 112 · see citing works
An experimental study of the placebo response under three different situations of pain
Liberman, R. P. (1964) · Journal of Psychiatric Research · doi:10.1016/0022-3956(64)90010-x · Cited by 96 · see citing works
Is fear of pain related to placebo analgesia?
Lyby, P. S., Aslaksen, P. M., & Flaten, M. A. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.10.009 · Cited by 94 · see citing works
Lu, H.-C., Hsieh, J., Lu, C.-L., Niddam, D., Wu, Y.-T., Yeh, T., Cheng, C.-M., Chang, F., & Lee, S.-D. (2010) · Pain · doi:10.1016/j.pain.2009.10.012 · Cited by 93 · see citing works
Attentional Modulation of Spatial Integration of Pain: Evidence for Dynamic Spatial Tuning
de Quevedo, A. S., & Coghill, R. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3356-07.2007 · Cited by 91 · see citing works
Brown, C. A., Seymour, B., El-Deredy, W., & Jones, A. K. P. (2008) · Pain · doi:10.1016/j.pain.2008.04.028 · Cited by 83 · see citing works
Placebo analgesia is not due to compliance or habituation: EEG and behavioural evidence
Watson, A., El-Deredy, W., Vogt, B. A., & Jones, A. K. P. (2007) · NeuroReport · doi:10.1097/wnr.0b013e3280c1e2a8 · Cited by 79 · see citing works
Placebo and Endogenous Mechanisms of Analgesia
Benedetti, F. (2007) · Springer eBooks · doi:10.1007/978-3-540-33823-9_14 · Cited by 58 · see citing works
The new field of Brain–Body Medicine: What have we learned and where are we headed?
Lane, R. D., & Wager, T. D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.013 · Cited by 52 · see citing works
Self-citationPlacebo analgesia as a case of a cognitive style driven by prior expectation
Morton, D. L., El‐Deredy, W., Watson, A., & Jones, A. K. P. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.046 · Cited by 51 · see citing works
The reliability and validity of a placebo test
Shapiro, A. K., Struening, E. L., & Shapiro, E. (1979) · Journal of Psychiatric Research · doi:10.1016/0022-3956(79)90016-5 · Cited by 32 · see citing works
Course of treatment received by depressed patients
Dawson, R., Lavori, P. W., Coryell, W. H., Endicott, J., & Keller, M. B. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00055-7 · Cited by 27 · see citing works
Antidepressant study design affects patient expectancy: a pilot study
Rutherford, B. R., Sneed, J. R., Devanand, D. P., Eisenstadt, R., & Roose, S. P. (2009) · Psychological Medicine · doi:10.1017/s0033291709991085 · Cited by 24 · see citing works
Elastic source selection for in vivo imaging of neuronal ensembles
Grosenick, L., Anderson, T., & Smith, S. J. (2009) · IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI) · doi:10.1109/isbi.2009.5193292 · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Bishop CM 2006 Pattern recognition and machine learning New York Springer
Cited by
Sorted by citations
The integration of negative affect, pain and cognitive control in the cingulate cortex
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2994 · Cited by 2,082 · see citing works
Ochsner, K. N., Silvers, J. A., & Buhle, J. T. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06751.x · Cited by 1,879 · see citing works
An fMRI-Based Neurologic Signature of Physical Pain
Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., & Kross, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1204471 · Cited by 1,597 · see citing works
Self-citationBuilding better biomarkers: brain models in translational neuroimaging
Woo, C.-W., Chang, L. J., Lindquist, M. A., & Wager, T. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4478 · Cited by 1,056 · see citing works
Self-citationVentromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856 · see citing works
Self-citationThe neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844 · see citing works
Self-citationThe placebo response in medicine: minimize, maximize or personalize?
Enck, P., Bingel, U., Schedlowski, M., & Rief, W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3923 · Cited by 671 · see citing works
Prediction as a Humanitarian and Pragmatic Contribution from Human Cognitive Neuroscience
Gabrieli, J. D. E., Ghosh, S., & Whitfield, S. (2015) · Neuron · doi:10.1016/j.neuron.2014.10.047 · Cited by 526 · see citing works
Placebo Analgesia: A Predictive Coding Perspective
Büchel, C., Geuter, S., Sprenger, C., & Eippert, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.042 · Cited by 505 · see citing works
Placebo and the New Physiology of the Doctor-Patient Relationship
Benedetti, F. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2012 · Cited by 492 · see citing works
Atlas, L. Y., & Wager, T. D. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.039 · Cited by 463 · see citing works
Self-citationZeidan, F., Emerson, N. M., Farris, S. R., Ray, J. N., Jung, Y., McHaffie, J. G., & Coghill, R. C. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2542-15.2015 · Cited by 369 · see citing works
A Sensitive and Specific Neural Signature for Picture-Induced Negative Affect
Chang, L. J., Gianaros, P. J., Manuck, S. B., Krishnan, A., & Wager, T. D. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002180 · Cited by 336 · see citing works
Self-citationSchedlowski, M., Enck, P., Rief, W., & Bingel, U. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009423 · Cited by 323 · see citing works
Placebo Effects: From the Neurobiological Paradigm to Translational Implications
Benedetti, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.023 · Cited by 316 · see citing works
Mindfulness meditation-based pain relief: a mechanistic account
Zeidan, F., & Vago, D. R. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13153 · Cited by 300 · see citing works
Gard, T., Holzel, B. K., Sack, A. T., Hempel, H., Lazar, S. W., Vaitl, D., & Ott, U. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr352 · Cited by 276 · see citing works
Placebo analgesia: Psychological and neurobiological mechanisms
Colloca, L., Klinger, R., Flor, H., & Bingel, U. (2013) · Pain · doi:10.1016/j.pain.2013.02.002 · Cited by 263 · see citing works
The placebo effect: From concepts to genes
Colagiuri, B., Schenk, L. A., Keßler, M., Dorsey, S. G., & Colloca, L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.017 · Cited by 260 · see citing works
Rütgen, M., Seidel, E.-M., Silani, G., Riečanský, I., Hummer, A., Windischberger, C., Petrovic, P., & Lamm, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511269112 · Cited by 208 · see citing works
Amanzio, M., Benedetti, F., Porro, C. A., Palermo, S., & Cauda, F. (2013) · Human Brain Mapping · doi:10.1002/hbm.21471 · Cited by 202 · see citing works
Interpretable whole-brain prediction analysis with GraphNet
Grosenick, L., Klingenberg, B., Katovich, K., Knutson, B. D., & Taylor, J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.062 · Cited by 197 · see citing works
A neuroimaging biomarker for sustained experimental and clinical pain
Lee, J., Kim, H. J., Čeko, M., Park, B., Lee, S. A., Park, H., Roy, M., Kim, S., Wager, T. D., & Woo, C. (2021) · Nature Medicine · doi:10.1038/s41591-020-1142-7 · Cited by 188 · see citing works
Self-citationBrain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials
Tétreault, P., Mansour, A. R., Vachon‐Presseau, É., Schnitzer, T. J., Apkarian, A. V., & Baliki, M. N. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002570 · Cited by 187 · see citing works
Brain Mechanisms of the Placebo Effect: An Affective Appraisal Account
Ashar, Y. K., Chang, L. J., & Wager, T. D. (2017) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-021815-093015 · Cited by 191 · see citing works
Self-citationFunctional connectivity of the frontoparietal network predicts cognitive modulation of pain
Kong, J., Jensen, K. B., Loiotile, R. E., Cheetham, A., Wey, H., Tan, Y. H. V., Rosen, B. R., Smoller, J. W., Kaptchuk, T. J., & Gollub, R. L. (2012) · Pain · doi:10.1016/j.pain.2012.12.004 · Cited by 182 · see citing works
Functional dissociation of stimulus intensity encoding and predictive coding of pain in the insula
Geuter, S., Boll, S., Eippert, F., & Büchel, C. (2017) · eLife · doi:10.7554/elife.24770 · Cited by 184 · see citing works
Bright, I., Lin, G., & Kutz, J. N. (2013) · Physics of Fluids · doi:10.1063/1.4836815 · Cited by 179 · see citing works
The placebo effect: advances from different methodological approaches
Meissner, K., Bingel, U., Colloca, L., Wager, T. D., Watson, A., & Flaten, M. A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4099-11.2011 · Cited by 178 · see citing works
Self-citationDissociable Influences of Opiates and Expectations on Pain
Atlas, L. Y., Whittington, R. A., Lindquist, M. A., Wielgosz, J., Sonty, N., & Wager, T. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0383-12.2012 · Cited by 172 · see citing works
Self-citationInteroceptive inference: From computational neuroscience to clinic
Owens, A. P., Allen, M., Ondobaka, S., & Friston, K. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.017 · Cited by 178 · see citing works
Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data
Zunhammer, M., Spisák, T., Wager, T. D., Bingel, U., The Placebo Imaging Consortium, Atlas, L., Benedetti, F., Büchel, C., Choi, J. C., Colloca, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21179-3 · Cited by 171 · see citing works
Self-citationPlacebo Effects on the Neurologic Pain Signature
Zunhammer, M., Bingel, U., & Wager, T. D. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.2017 · Cited by 166 · see citing works
Self-citationYoshida, W., Seymour, B., Koltzenburg, M., & Dolan, R. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4984-12.2013 · Cited by 165 · see citing works
Atlas, L. Y., & Wager, T. D. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-662-44519-8_3 · Cited by 162 · see citing works
Self-citationA neuromarker for drug and food craving distinguishes drug users from non-users
Koban, L., Wager, T. D., & Hedy Kober, A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01228-w · Cited by 150 · see citing works
Self-citationRossettini, G., Camerone, E. M., Carlino, E., Benedetti, F., & Testa, M. (2020) · Archives of Physiotherapy · doi:10.1186/s40945-020-00082-y · Cited by 164 · see citing works
Behavioural and neural evidence for self-reinforcing expectancy effects on pain
Jepma, M., Koban, L., van Doorn, J., Jones, M., & Wager, T. D. (2018) · Nature Human Behaviour · doi:10.1038/s41562-018-0455-8 · Cited by 155 · see citing works
Self-citationSmith, S. M., Dworkin, R. H., Turk, D. C., Baron, R., Polydefkis, M. J., Tracey, I., Borsook, D., Edwards, R. R., Harris, R. E., Wager, T. D., et al. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.02.429 · Cited by 149 · see citing works
Self-citationBeyond Neurovascular: Migraine as a Dysfunctional Neurolimbic Pain Network
Maizels, M., Aurora, S. K., & Heinricher, M. M. (2012) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2012.02209.x · Cited by 142 · see citing works
Neuroimaging-based biomarkers for pain: state of the field and current directions
van der Miesen, M. M., Lindquist, M. A., & Wager, T. D. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000751 · Cited by 137 · see citing works
Self-citationPain-free resting-state functional brain connectivity predicts individual pain sensitivity
Spisák, T., Kincses, B., Schlitt, F., Zunhammer, M., Schmidt‐Wilcke, T., Kincses, Z. T., & Bingel, U. (2020) · Nature Communications · doi:10.1038/s41467-019-13785-z · Cited by 131 · see citing works
Cortical and subcortical responses to high and low effective placebo treatments
Geuter, S., Eippert, F., Attar, C. H., & Büchel, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.029 · Cited by 130 · see citing works
Kaplan, C. M., Nascimento, T. D., Foerster, B. R., Clauw, D. J., Zubieta, J., Harris, R. E., & DaSilva, A. F. M. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-0934-0 · Cited by 135 · see citing works
Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information
Nahman‐Averbuch, H., Martucci, K. T., Granovsky, Y., Weissman‐Fogel, I., Yarnitsky, D., & Coghill, R. C. (2014) · Pain · doi:10.1016/j.pain.2014.07.008 · Cited by 128 · see citing works
Modeling Pain Using fMRI: From Regions to Biomarkers
Reddan, M. C., & Wager, T. D. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0150-1 · Cited by 122 · see citing works
Self-citationResting state connectivity correlates with drug and placebo response in fibromyalgia patients
Schmidt-Wilcke, T., Ichesco, E., Hampson, J. P., Kairys, A., Peltier, S., Harte, S., Clauw, D. J., & Harris, R. E. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.09.007 · Cited by 122 · see citing works
Tu, Y., Jung, M., Gollub, R. L., Napadow, V., Gerber, J. A., Ortiz, A., Lang, C., Mawla, I., Shen, W., Chan, S., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001507 · Cited by 121 · see citing works
Brain and psychological determinants of placebo pill response in chronic pain patients
Vachon‐Presseau, É., Berger, S., Abdullah, T. B., Huang, L., Cecchi, G., Griffith, J. W., Schnitzer, T. J., & Apkarian, A. V. (2018) · Nature Communications · doi:10.1038/s41467-018-05859-1 · Cited by 118 · see citing works
Stein, N., Sprenger, C., Scholz, J., Wiech, K., & Bingel, U. (2012) · Pain · doi:10.1016/j.pain.2012.07.010 · Cited by 116 · see citing works
Brain networks predicting placebo analgesia in a clinical trial for chronic back pain
Hashmi, J. A., Baria, A. T., Baliki, M. N., Huang, L., Schnitzer, T. J., & Apkarian, V. A. (2012) · Pain · doi:10.1016/j.pain.2012.08.008 · Cited by 115 · see citing works
Zeidan, F., Baumgartner, J. N., & Coghill, R. C. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000759 · Cited by 115 · see citing works
The periaqueductal gray and Bayesian integration in placebo analgesia
Grahl, A., Onat, S., & Büchel, C. (2018) · eLife · doi:10.7554/elife.32930 · Cited by 110 · see citing works
Plaßmann, H., & Weber, B. (2015) · Journal of Marketing Research · doi:10.1509/jmr.13.0613 · Cited by 111 · see citing works
Placebo improves pleasure and pain through opposite modulation of sensory processing
Ellingsen, D., Wessberg, J., Eikemo, M., Liljencrantz, J., Endestad, T., Olausson, H., & Leknes, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305050110 · Cited by 110 · see citing works
Carlino, E., Frisaldi, E., & Benedetti, F. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.17 · Cited by 108 · see citing works
Fazeli, S., & Büchel, C. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0671-18.2018 · Cited by 109 · see citing works
Distraction and Placebo: Two Separate Routes to Pain Control
Buhle, J. T., Stevens, B. L., Friedman, J. J., & Wager, T. D. (2012) · Psychological Science · doi:10.1177/0956797611427919 · Cited by 105 · see citing works
Self-citationDifferent contexts, different pains, different experiences
Carlino, E., & Benedetti, F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.053 · Cited by 107 · see citing works
Variability in placebo analgesia and the role of fear of pain—an ERP study
Lyby, P. S., Aslaksen, P. M., & Flaten, M. A. (2011) · Pain · doi:10.1016/j.pain.2011.07.010 · Cited by 103 · see citing works
Elsenbruch, S., Kotsis, V., Benson, S., Rosenberger, C., Reidick, D., Schedlowski, M., Bingel, U., Theysohn, N., Forsting, M., & Gizewski, E. (2012) · Pain · doi:10.1016/j.pain.2011.10.036 · Cited by 112 · see citing works
Molecular Mechanisms of Placebo Responses In Humans
Peciña, M., & Zubieta, J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.164 · Cited by 96 · see citing works
Gay, C. W., Robinson, M. E., George, S. Z., Perlstein, W. M., & Bishop, M. D. (2014) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/j.jmpt.2014.09.001 · Cited by 93 · see citing works
Beyond conformity: Social influences on pain reports and physiology.
Koban, L., & Wager, T. D. (2016) · Emotion · doi:10.1037/emo0000087 · Cited by 92 · see citing works
Self-citationTu, Y., Ortiz, A., Gollub, R. L., Cao, J., Gerber, J. A., Lang, C., Park, J., Wilson, G., Shen, W., Chan, S., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101885 · Cited by 91 · see citing works
Different brain networks mediate the effects of social and conditioned expectations on pain
Koban, L., Jepma, M., López‐Solà, M., & Wager, T. D. (2019) · Nature Communications · doi:10.1038/s41467-019-11934-y · Cited by 88 · see citing works
Self-citationSalience Network Functional Connectivity Predicts Placebo Effects in Major Depression
Sikora, M., Heffernan, J., Avery, E. T., Mickey, B. J., Zubieta, J.-K., & Peciña, M. (2016) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.10.002 · Cited by 85 · see citing works
Neural and sociocultural mediators of ethnic differences in pain
Losin, E. A. R., Woo, C., Medina, N. A., Andrews‐Hanna, J. R., Eisenbarth, H., & Wager, T. D. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-0819-8 · Cited by 83 · see citing works
Self-citationDifferential neurophysiological correlates of bottom-up and top-down modulations of pain
Tiemann, L., May, E. S., Postorino, M., Schulz, E., Nickel, M. M., Bingel, U., & Ploner, M. (2015) · Pain · doi:10.1097/01.j.pain.0000460309.94442.44 · Cited by 81 · see citing works
Changes in resting-state brain networks after cognitive–behavioral therapy for chronic pain
Yoshino, A., Okamoto, Y., Okada, G., Takamura, M., Ichikawa, N., Shibasaki, C., Yokoyama, S., Doi, M., Jinnin, R., Yamashita, H., et al. (2017) · Psychological Medicine · doi:10.1017/s0033291717002598 · Cited by 80 · see citing works
Schafer, S. M., Geuter, S., & Wager, T. D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.008 · Cited by 78 · see citing works
Self-citationA Brain Phenotype for Stressor‐Evoked Blood Pressure Reactivity
Gianaros, P., Lei, S. K., Uyar, F., Koushik, J., Jennings, J., Wager, T., Singh, A., & Verstynen, T. (2017) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.117.006053 · Cited by 67 · see citing works
Self-citationYu, R., Gollub, R. L., Vangel, M. G., Kaptchuk, T. J., Smoller, J. W., & Kong, J. (2014) · Human Brain Mapping · doi:10.1002/hbm.22496 · Cited by 79 · see citing works
Jacobucci, R., Brandmaier, A. M., & Kievit, R. (2019) · Advances in Methods and Practices in Psychological Science · doi:10.1177/2515245919826527 · Cited by 78 · see citing works
Hashmi, J. A., Kong, J., Spaeth, R. B., Khan, S., Kaptchuk, T. J., & Gollub, R. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3155-13.2014 · Cited by 76 · see citing works
Anticipatory brain activity predicts the success or failure of subsequent emotion regulation
Denny, B. T., Ochsner, K. N., Weber, J., & Wager, T. D. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss148 · Cited by 75 · see citing works
Self-citationA preliminary study of the effects of working memory training on brain function
Stevens, M. C. G., Gaynor, A. M., Bessette, K. L., & Pearlson, G. D. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9416-2 · Cited by 71 · see citing works
Multiple Brain Networks Mediating Stimulus–Pain Relationships in Humans
Geuter, S., Losin, E. A. R., Roy, M., Atlas, L. Y., Schmidt, L., Krishnan, A., Koban, L., Wager, T. D., & Lindquist, M. A. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa048 · Cited by 65 · see citing works
Self-citationKutch, J. J., Labus, J. S., Harris, R. E., Martucci, K. T., Farmer, M. A., Fenske, S. J., Fling, C., Ichesco, E., Peltier, S., Petre, B., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000886 · Cited by 68 · see citing works
Castelnuovo, G., Giusti, E. M., Manzoni, G. M., Saviola, D., Gabrielli, S., Lacerenza, M. R., Pietrabissa, G., Cattivelli, R., Spatola, C. A. M., Rossi, A. A., et al. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00310 · Cited by 65 · see citing works
The Biology of Placebo and Nocebo Effects on Experimental and Chronic Pain: State of the Art
Rossettini, G., Campaci, F., Bialosky, J. E., Huysmans, E., Vase, L., & Carlino, E. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12124113 · Cited by 68 · see citing works
Murray, D., & Stoessl, A. J. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.009 · Cited by 65 · see citing works
Gollub, R. L., Kirsch, I., Maleki, N., Wasan, A. D., Edwards, R. R., Tu, Y., Kaptchuk, T. J., & Kong, J. (2018) · Journal of Pain · doi:10.1016/j.jpain.2017.12.260 · Cited by 66 · see citing works
Group-regularized individual prediction: theory and application to pain
Lindquist, M. A., Krishnan, A., López‐Solà, M., Jepma, M., Woo, C., Koban, L., Roy, M., Atlas, L. Y., Schmidt, L., Chang, L. J., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.074 · Cited by 62 · see citing works
Self-citationEgorova, N., Yu, R., Kaur, N., Vangel, M., Gollub, R. L., Dougherty, D. D., Kong, J., & Camprodon, J. A. (2015) · Pain · doi:10.1097/j.pain.0000000000000163 · Cited by 63 · see citing works
Parametric trial-by-trial prediction of pain by easily available physiological measures
Geuter, S., Gamer, M., Onat, S., & Büchel, C. (2014) · Pain · doi:10.1016/j.pain.2014.02.005 · Cited by 63 · see citing works
Darnall, B. D., & Colloca, L. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.022 · Cited by 65 · see citing works
Disgust regulation via placebo: an fMRI study
Schienle, A., Übel, S., Schöngaßner, F., Ille, R., & Scharmüller, W. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst072 · Cited by 61 · see citing works
Review of neuroimaging studies related to pain modulation
Knudsen, L., Petersen, G. L., Nørskov, K. N., Vase, L., Finnerup, N. B., Jensen, T. S., & Svensson, P. J. (2011) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2011.05.005 · Cited by 60 · see citing works
Predictive Dynamics of Human Pain Perception
Cecchi, G., Huang, L. Q., Hashmi, J. A., Baliki, M. N., Centeno, M. V., Rish, I., & Apkarian, A. V. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002719 · Cited by 61 · see citing works
A network of amygdala connections predict individual differences in trait anxiety
Greening, S. G., & Mitchell, D. G. V. (2015) · Human Brain Mapping · doi:10.1002/hbm.22952 · Cited by 61 · see citing works
Khan, H. S., & Stroman, P. W. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.059 · Cited by 59 · see citing works
Bodien, Y. G., Ferrarelli, F., Shackman, A. J., Sarasso, S., Peterson, M. J., Langheim, F. J. P., Meyerand, M. E., Tononi, G., & Postle, B. R. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.23 · Cited by 59 · see citing works
Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection
Koban, L., Kross, E. F., Woo, C., Ruzic, L. L., & Wager, T. D. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2658-16.2017 · Cited by 57 · see citing works
Self-citationPlacebo and nocebo effects across symptoms: from pain to fatigue, dyspnea, nausea, and itch
Wolters, F., Peerdeman, K. J., & Evers, A. W. M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00470 · Cited by 57 · see citing works
A social affective neuroscience lens on placebo analgesia
Atlas, L. Y. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.07.016 · Cited by 56 · see citing works
Self-citationHypnotic susceptibility modulates brain activity related to experimental placebo analgesia
Huber, A., Lui, F., & Porro, C. A. (2013) · Pain · doi:10.1016/j.pain.2013.03.031 · Cited by 53 · see citing works
Altruistic behaviors relieve physical pain
Wang, Y., Ge, J., Zhang, H., Wang, H., & Xie, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911861117 · Cited by 55 · see citing works
Flowers, K. M., Patton, M. E., Hruschak, V., Fields, K. G., Schwartz, E., Zeballos, J., Kang, J. D., Edwards, R. R., Kaptchuk, T. J., & Schreiber, K. L. (2021) · Pain · doi:10.1097/j.pain.0000000000002185 · Cited by 52 · see citing works
Hoeppli, M., Nahman‐Averbuch, H., Hinkle, W., Leon, E., Peugh, J., López‐Solà, M., King, C. D., Goldschneider, K. R., & Coghill, R. C. (2022) · Nature Communications · doi:10.1038/s41467-022-31039-3 · Cited by 50 · see citing works
- Authors
- Wager, T. D., Atlas, L. Y., Leotti, L. A., & Rilling, J. K.
- Affiliations
- University of Colorado Boulder (US)
- Columbia University (US)
- Rutgers, The State University of New Jersey (US)
- Emory University (US)
- Corresponding author
- Wager, Tor D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-01-12
- Volume
- 31
- Issue
- 2
- Pages
- 439-452
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3735131
- OpenAlex
- W2158440149
- Cited by
- 328
- References
- 96
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 25 · 2023: 26 · 2022: 13 · 2021: 16 · 2020: 22 · 2019: 18 · 2018: 20 · 2017: 27 · 2016: 18 · 2015: 24 · 2014: 23 · 2013: 29 · 2012: 24
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Journal of Neuroscience Nursing
- Funders
- John D. and Catherine T. MacArthur Foundation
- Kohlberg Foundation
- National Institutes of Health (MH076136)
- National Institute of Mental Health (MH076136, R01MH076136, R37MH076136)
- National Institute on Drug Abuse (RC1DA028608, R01DA027794)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- placebo analgesia, individual differences, pain experience, emotional appraisal, frontoparietal network, posterior insula, paralimbic regions, pain processing, nociception
- MeSH terms
- Analgesia, Analgesics, Brain, Cerebral Cortex, Data Interpretation, Statistical, Humans, Individuality, Magnetic Resonance Imaging, Nerve Net, Pain, Regression Analysis, Placebo Effect, Cluster Analysis, Anticipation, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
