Cited by 243Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsMusculoskeletal pain and rehabilitation

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Treatment of fibromyalgia syndrome with gabapentin and pregabalin – A meta-analysis of randomized controlled trials

Häuser, Winfried, Bernardy, Kathrin, Üçeyler, Nurcan, Sommer, Claudia·2009·Pain

DOI 10.1016/j.pain.2009.05.014

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Abstract

The efficacy of gabapentin (GPT) and pregabalin (PGB) in the treatment of fibromyalgia syndrome (FMS) was assessed. We screened MEDLINE, PsycINFO, SCOPUS, www.clinicaltrials.org, the Cochrane Library (through October 2008), and the reference sections of original studies on GPT/PGB in FMS. Randomized controlled trials (RCTs) on the treatment of FMS with GPT and PGB were analyzed. Six out of 127 RCTs studying 2422 subjects on treatment with GPT (one study) or PGB (five studies) and 1056 subjects on placebo with a median treatment duration of 11 weeks were included into the systematic review. Five studies were suitable for meta-analysis. Effects were summarized using standardized mean differences (SMD). There was strong evidence for a reduction of pain (SMD -0.28, 95% CI -0.36, -0.20; p<0.001), improved sleep (SMD -0.39, 95% CI -0.48, -0.39; p<0.001), and improved health-related quality of life (HRQOL) (SMD -0.30, 95% CI -0.46, -0.15; p<0.001), but not for depressed mood (SMD -0.12, 95% CI -0.30, 0.06; p=0.18). There was strong evidence for a non-substantial reduction of fatigue (SMD -0.16, 95% CI -0.23, -0.09, p<0.001) and of anxiety (SMD -0.18, 95% CI -0.27, -0.10; p<0.001). The external validity of the studies was limited because patients with severe somatic and mental disorders were excluded.

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Self-citation
CHRONIC OPIOID USE IN FIBROMYALGIA SYNDROME: CHARACTERISTICS AND OUTCOMES
Painter, J. T. (2012) · UKnowledge (University of Kentucky)
Gabapentin
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Theadom, A. (2011) · Tuwhera (Auckland University of Technology)

Authors: Häuser, W., Bernardy, K., Üçeyler, N., & Sommer, C.
Affiliations: Klinikum Saarbrücken (DE)
Saarland University (DE)
University of Würzburg (DE)
Corresponding author: Häuser, Winfried
ORCID: Häuser, Winfried
Üçeyler, Nurcan
Sommer, Claudia
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-09
Volume: 145
Issue: 1
Pages: 69-81
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2009.05.014
OpenAlex: W2023541450
Cited by: 243
References: 43
Citations by year: 2026: 8 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 15 · 2013: 23 · 2012: 24
FWCI: 3.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders: Eli Lilly and Company
Pfizer
Cilag
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords: fibromyalgia, gabapentin, pregabalin, analgesia, sleep quality, health-related quality of life, fatigue, anxiety, depressive mood, antiepileptic drugs
MeSH terms: Pregabalin, Gabapentin, Amines, Analgesics, Calcium Channel Blockers, Cyclohexanecarboxylic Acids, Fibromyalgia, gamma-Aminobutyric Acid, Humans, Reproducibility of Results, Randomized Controlled Trials as Topic, Databases, Bibliographic

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Treatment of fibromyalgia syndrome with gabapentin and pregabalin – A meta-analysis of randomized controlled trials

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