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Cited by 243Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsMusculoskeletal pain and rehabilitation

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Treatment of fibromyalgia syndrome with gabapentin and pregabalin – A meta-analysis of randomized controlled trials

Häuser, Winfried, Bernardy, Kathrin, Üçeyler, Nurcan, Sommer, Claudia·2009·Pain
DOI 10.1016/j.pain.2009.05.014
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Abstract

The efficacy of gabapentin (GPT) and pregabalin (PGB) in the treatment of fibromyalgia syndrome (FMS) was assessed. We screened MEDLINE, PsycINFO, SCOPUS, www.clinicaltrials.org, the Cochrane Library (through October 2008), and the reference sections of original studies on GPT/PGB in FMS. Randomized controlled trials (RCTs) on the treatment of FMS with GPT and PGB were analyzed. Six out of 127 RCTs studying 2422 subjects on treatment with GPT (one study) or PGB (five studies) and 1056 subjects on placebo with a median treatment duration of 11 weeks were included into the systematic review. Five studies were suitable for meta-analysis. Effects were summarized using standardized mean differences (SMD). There was strong evidence for a reduction of pain (SMD -0.28, 95% CI -0.36, -0.20; p<0.001), improved sleep (SMD -0.39, 95% CI -0.48, -0.39; p<0.001), and improved health-related quality of life (HRQOL) (SMD -0.30, 95% CI -0.46, -0.15; p<0.001), but not for depressed mood (SMD -0.12, 95% CI -0.30, 0.06; p=0.18). There was strong evidence for a non-substantial reduction of fatigue (SMD -0.16, 95% CI -0.23, -0.09, p<0.001) and of anxiety (SMD -0.18, 95% CI -0.27, -0.10; p<0.001). The external validity of the studies was limited because patients with severe somatic and mental disorders were excluded.

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Research works printed but not linked: 1

  1. Staud, 2008, Long-term trials of pregabalin and duloxetine for fibromyalgia symptoms: How study designs can effect placebo factors., Pain, 232-, 234

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Metadata

Authors
Häuser, W., Bernardy, K., Üçeyler, N., & Sommer, C.
Affiliations
  • Klinikum Saarbrücken (DE)
  • Saarland University (DE)
  • University of Würzburg (DE)
Corresponding author
Häuser, Winfried
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-09
Volume
145
Issue
1
Pages
69-81
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/j.pain.2009.05.014
OpenAlex
W2023541450
Cited by
243
References
43
Citations by year
2026: 8 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 15 · 2013: 23 · 2012: 24
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders
  • Eli Lilly and Company
  • Pfizer
  • Cilag
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords
fibromyalgia, gabapentin, pregabalin, analgesia, sleep quality, health-related quality of life, fatigue, anxiety, depressive mood, antiepileptic drugs
MeSH terms
Pregabalin, Gabapentin, Amines, Analgesics, Calcium Channel Blockers, Cyclohexanecarboxylic Acids, Fibromyalgia, gamma-Aminobutyric Acid, Humans, Reproducibility of Results, Randomized Controlled Trials as Topic, Databases, Bibliographic

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