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Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome
Open accessAbstract
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder in which the underlying pathophysiology is poorly understood; however, increased intestinal permeability in diarrhea-predominant IBS patients has been reported. Here we demonstrate that diarrhea-predominant IBS (D-IBS) patients display increased intestinal permeability. We have also found that increased intestinal membrane permeability is associated with visceral and thermal hypersensitivity in this subset of D-IBS patients. We evaluated 54 D-IBS patients and 22 controls for intestinal membrane permeability using the lactulose/mannitol method. All subjects ingested 5g of lactulose and 2g of mannitol in 100ml of water after which their urine was collected. We also evaluated the mean mechanical visual analogue scale (M-VAS) pain rating to nociceptive thermal and visceral stimulation in all subjects. All study participants also completed the FBDSI scale. Approximately 39% of diarrhea-predominant IBS patients had increased intestinal membrane permeability as measured by the lactulose/mannitol ratio. These IBS patients also demonstrated higher M-VAS pain intensity reading scale. Interestingly, the IBS patients with hypersensitivity and increased intestinal permeability had a higher FBDSI score (100.8 + or - 5.4) than IBS patients with normal membrane permeability and sensitivity (51.6 + or - 12.7) and controls (6.1 + or - 5.6) (p<0.001). A subset of D-IBS patients had increased intestinal membrane permeability that was associated with an increased FBDSI score and increased hypersensitivity to visceral and thermal nociceptive pain stimuli. Thus, increased intestinal membrane permeability in D-IBS patients may lead to more severe IBS symptoms and hypersensitivity to somatic and visceral stimuli.
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Cites
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Price, D. D., Bush, F. M., Long, S., & Harkins, S. W. (1994) · Pain · doi:10.1016/0304-3959(94)90097-3 · Cited by 1,174
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Immunity, Inflammation, and Allergy in the Gut
MacDonald, T. T., & Monteleone, G. (2005) · Science · doi:10.1126/science.1106442 · Cited by 1,051
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024
Intestinal permeability: an overview
Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920
Al–Chaer, E. D., Kawasaki, M., & Pasricha, P. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.19576 · Cited by 727
Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome
Whitehead, W. E., Holtkötter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J. C., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 592
Sex-related hormonal influences on pain and analgesic responses
Fillingim, R. B., & Ness, T. J. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00017-8 · Cited by 554
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Items 101–200 of 373
Nozu, T., Miyagishi, S., Kumei, S., Nozu, R., Takakusaki, K., & Okumura, T. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13808 · Cited by 63
González-Castro, A. M., Martínez, C., Salvo‐Romero, E., Fortea, M., Pardo‐Camacho, C., Pérez, T., Alonso, C., Santos, J., & Vicario, M. (2016) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13417 · Cited by 66
Disorders of Gut–Brain Interaction and the Rome V Process
Drossman, D. A., Chang, L., & Tack, J. F. (2026) · Gastroenterology · doi:10.1053/j.gastro.2026.02.014 · Cited by 69
Rengarajan, S., Knoop, K. A., Rengarajan, A., Chai, J. N., Grajales‐Reyes, J. G., Samineni, V. K., Russler-Germain, E. V., Ranganathan, P., Fasano, A., Sayuk, G. S., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100124 · Cited by 63
Epigenetic mechanisms in irritable bowel syndrome
Mahurkar-Joshi, S., & Chang, L. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00805 · Cited by 59
“Additionally, an increase in paracellular permeability has been correlated with the magnitude of visceral pain in IBS-D patients (83).”
BackgroundDuodenal low‐grade inflammation and expression of tight junction proteins in functional dyspepsia
Taki, M., Oshima, T., Li, M., Sei, H., Tozawa, K., Tomita, T., Fukui, H., Watari, J., & Miwa, H. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13576 · Cited by 57
Ayyadurai, S., Gibson, A. J., D’Costa, S., Overman, E. L., Sommerville, L. J., Poopal, A. C., Mackey, E., Li, Y., & Moeser, A. J. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.2hi0317-088rr · Cited by 56
Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome.
Buckley, M. M., O’Mahony, S. M., & O’Malley, D. (2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8846 · Cited by 55
Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome
Nasser, Y., Boeckxstaens, G. E., Wouters, M. M., Schemann, M., & Vanner, S. J. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12316 · Cited by 53
Wilcz-Villega, E., McClean, S., & O'Sullivan, M. (2014) · Neurogastroenterology and Motility · doi:10.1111/nmo.12262 · Cited by 52
Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome
Chumpitazi, B. P., & Shulman, R. J. (2016) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-016-0036-8 · Cited by 52
Jin, Y. T., Ren, X., Li, G., Li, Y., Zhang, L., Wang, H., Qian, W., & Hou, X. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13841 · Cited by 52
Immune responses in the irritable bowel syndromes: time to consider the small intestine
Burns, G. L., Talley, N. J., & Keely, S. (2022) · BMC Medicine · doi:10.1186/s12916-022-02301-8 · Cited by 54
Revisiting concepts of visceral nociception in irritable bowel syndrome
Keszthelyi, D., Troost, F., Simrén, M., Ludidi, S., Kruimel, J., Conchillo, J., & Masclee, A. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00147.x · Cited by 44
Linsalata, M., Riezzo, G., Clemente, C., D’Attoma, B., & Russo, F. (2020) · Disease Markers · doi:10.1155/2020/2886268 · Cited by 55
Zhou, Q., Price, D. D., Callam, C. S., Woodruff, M. A., & Verne, G. N. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.09.002 · Cited by 50
Self-citationLudidi, S., Jonkers, D. M. A. E., Koning, C. J., Kruimel, J. W., Mulder, L. H. C., der Vaart, I. B.-V., Conchillo, J. M., & Masclee, A. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12320 · Cited by 51
Peters, S. A., Edogawa, S., Sundt, W. J., Dyer, R. B., Dalenberg, D. A., Mazzone, A., Singh, R. J., Moses, N., Smyrk, T. C., Weber, C., et al. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2017.48 · Cited by 48
Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease
Jalili, M., Hekmatdoost, A., Vahedi, H., Poustchi, H., Khademi, B., Saadi, M., Zemestani, M., & Janani, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158545 · Cited by 48
Penn, I., Chuang, E. Y.-Y., Chuang, T., Lin, C., & Kao, C. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026581 · Cited by 48
Mucosal permeability and mast cells as targets for functional gastrointestinal disorders
Keita, Å. V., & Söderholm, J. D. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.08.011 · Cited by 47
Bühner, S., Braak, B., Li, Q., Kugler, E. M., Klooker, T. K., Wouters, M. M., Donovan, J., Vignali, S., Mazzuoli‐Weber, G., Grundy, D., et al. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.080036 · Cited by 46
Tropical Sprue in 2014: the New Face of an Old Disease
Ghoshal, U. C., Srivastava, D., Verma, A., & Ghoshal, U. (2014) · Current Gastroenterology Reports · doi:10.1007/s11894-014-0391-3 · Cited by 44
Camilleri, M. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.261 · Cited by 47
Effects of Hypericum perforatum extract on rat irritable bowel syndrome
Abdollahi, M. R., Esmaily, H., Baeeri, M., Asadi-Shahmirzadi, A., Mozaffari, S., Rahimi, R., Sanei, Y., & Salehi-Surmaghi, M.-H. (2011) · Pharmacognosy Magazine · doi:10.4103/0973-1296.84235 · Cited by 47
Mechanisms of pain in sickle cell disease
Takaoka, K., Cyril, A. C., Jinesh, S., & Radhakrishnan, R. (2020) · British Journal of Pain · doi:10.1177/2049463720920682 · Cited by 50
Beckers, A. B., Weerts, Z. Z. R. M., Helyes, Z., Masclee, A., & Keszthelyi, D. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14294 · Cited by 45
Bertrand, J., Ghouzali, I., Guérin, C., Bôle‐Feysot, C., Gouteux, M., Déchelotte, P., Ducrotte, P. R., & Coëffier, M. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115587330 · Cited by 45
Intestinal Permeability in Disorders of Gut–Brain Interaction: From Bench to Bedside
Grover, M., Vanuytsel, T., & Chang, L. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.08.033 · Cited by 43
Ligon, C. O., Moloney, R. D., & Meerveld, B. G. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.231670 · Cited by 43
Long, Y., Du, L., Kim, J. J., Chen, B., Zhu, Y.-J., Zhang, Y., Yao, S., He, H., Zheng, X., Huang, Z., et al. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13348 · Cited by 40
Painful interactions: Microbial compounds and visceral pain
van Thiel, I. A. M., Botschuijver, S., de Jonge, W. J., & Seppen, J. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165534 · Cited by 44
Lim, E. Y., Song, E., Kim, J., Jung, S. Y., Lee, S.-Y., Shin, H. S., Nam, Y., & Kim, Y. T. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0217 · Cited by 43
Emerging Role of the Gut Microbiome in Irritable Bowel Syndrome
Singh, P., & Lembo, A. J. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.03.003 · Cited by 39
Review article: current and future treatment approaches for pain in IBS
Paine, P. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16550 · Cited by 42
Nevé, B. L., Posserud, I., Böhn, L., Guyonnet, D., Rondeau, P., Tillisch, K., Naliboff, B. D., Mayer, E. A., & Simrén, M. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.75 · Cited by 40
Biomarkers for visceral hypersensitivity in patients with irritable bowel syndrome
Mujagic, Z., Jonkers, D. M. A. E., Ludidi, S., Keszthelyi, D., Hesselink, M., Weerts, Z. Z. R. M., Kievit, R. N., Althof, J. F., Leue, C., Kruimel, J. W., et al. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13137 · Cited by 41
IBS-like symptoms in patients with ulcerative colitis
Gracie, D. J., & Ford, A. C. (2015) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s58153 · Cited by 42
Rifaximin, gut microbes and mucosal inflammation: unraveling a complex relationship
Gao, J., Gillilland, M. G., & Owyang, C. (2014) · Gut Microbes · doi:10.4161/gmic.32130 · Cited by 39
Creekmore, A. L., Hong, S., Zhu, S., Xue, J., & Wiley, J. W. (2018) · Pain · doi:10.1097/j.pain.0000000000001271 · Cited by 38
Latest Insights on the Pathogenesis of Irritable Bowel Syndrome
Videlock, E. J., & Chang, L. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.04.002 · Cited by 38
The shifting interface between IBS and IBD
Spiller, R. E., & Lam, C. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.09.009 · Cited by 38
Zhao, J., Wang, J., Dong, L., Shi, H., Wang, Z., Ding, H., Shi, H., & Lu, X. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.032 · Cited by 35
Gut microbiota and intestinal immunity—A crosstalk in irritable bowel syndrome
Chen, Y., Feng, S., Li, Y., Zhang, C., Chao, G., & Zhang, S. (2024) · Immunology · doi:10.1111/imm.13749 · Cited by 36
Immunomodulation of enteric neural function in irritable bowel syndrome
O’Malley, D. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i24.7362 · Cited by 35
Li, G., Yang, M. J., Jin, Y. T., Li, Y., Qian, W., Xiong, H., Song, J., & Hou, X. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14059 · Cited by 35
Barbaro, M. R., Fuschi, D., Cremon, C., Carapelle, M., Dino, P., Marcellini, M. M., Dothel, G., Ponti, F. D., Stanghellini, V., & Barbara, G. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13388 · Cited by 34
Xu, X., Liu, L., & Yao, S. (2016) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1500181 · Cited by 35
Soy Isoflavones and Gastrointestinal Health
Al‐Nakkash, L., & Kubinski, A. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00314-4 · Cited by 33
Grover, M., Berumen, A., Peters, S., Wei, T., Breen‐Lyles, M. K., Harmsen, W. S., Busciglio, I. A., Burton, D. D., Roque, M. V., DeVault, K. R., et al. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16591 · Cited by 33
Ishimoto, H., Oshima, T., Sei, H., Yamasaki, T., Kondo, T., Tozawa, K., Tomita, T., Ohda, Y., Fukui, H., Watari, J., et al. (2017) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.16-92 · Cited by 32
Immune Activation in Functional Gastrointestinal Disorders.
Burns, G. L., Pryor, J., Holtmann, G., Walker, M. M., Talley, N. J., & Keely, S. (2019) · PubMed Central · Cited by 32
Overlap between Irritable Bowel Syndrome and Inflammatory Bowel Disease
Spiller, R. E. (2009) · Digestive Diseases · doi:10.1159/000268121 · Cited by 31
Verne, G. N., Price, D. D., Callam, C. S., Zhang, B., Peck, J., & Zhou, Q. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.06.002 · Cited by 31
Self-citationPsychological stress‐induced colonic barrier dysfunction: Role of immune‐mediated mechanisms
Hattay, P., Prusator, D. K., Tran, L., & Meerveld, B. G. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13043 · Cited by 30
Axelrod, C. L., Brennan, C. J., Cresci, G., Paul, D., Hull, M. M., Fealy, C. E., & Kirwan, J. P. (2019) · Physiological Reports · doi:10.14814/phy2.14276 · Cited by 32
Riva, A., Giacomelli, L., Togni, S., Franceschi, F., Eggenhöffner, R., Zuccarini, M., & Belcaro, G. V. (2019) · Minerva Gastroenterologica e Dietologica · doi:10.23736/s1121-421x.18.02530-8 · Cited by 29
Guilarte, M., Vicario, M., Martínez, C., de Torres, I., Lobo, B., Pigrau, M., González-Castro, A., Rodiño-Janeiro, B., Salvo-Romero, E., Fortea, M., et al. (2020) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000789 · Cited by 28
Bueno, L. P., Beaufrand, C., Théodorou, V., & Andro-Delestrain, M.-C. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12021 · Cited by 29
miRNA-based therapies for the irritable bowel syndrome
Zhou, Q., & Verne, G. N. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.577060 · Cited by 29
Self-citationPhua, L. C., Wilder‐Smith, C. H., Tan, Y. M., Gopalakrishnan, T., Wong, R. K. M., Li, X., Kan, M. E., Jia, L., Keshavarzian, A., & Chan, E. C. Y. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00603 · Cited by 29
Hassan, E. A., El‐Rehim, A. S. E. A., Kholef, E. F., & Elsewify, W. A. E. (2020) · Gastroenterology and hepatology from bed to bench. · Cited by 25
Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome
Sinagra, E., Romano, C., & Cottone, M. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/486067 · Cited by 27
Experimental endotoxemia as a model to study neuroimmune mechanisms in human visceral pain
Benson, S., Engler, H., Schedlowski, M., & Elsenbruch, S. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06622.x · Cited by 27
Moussa, L., Bézirard, V., Salvador–Cartier, C., Bacquie, V., Houdeau, É., & Théodorou, V. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.05.021 · Cited by 26
JohnBritto, J. S., Ciaula, A. D., Noto, A., Cassano, V., Sciacqua, A., Khalil, M., Portincasa, P., & Bonfrate, L. (2024) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2024.03.011 · Cited by 29
Stress-induced intestinal barrier dysfunction is exacerbated during diet-induced obesity
Bahlouli, W., Breton, J., Lelouard, M., L’Huillier, C., Tirelle, P., Salameh, É., Amamou, A., Atmani, K., Goichon, A., Bôle‐Feysot, C., et al. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108382 · Cited by 27
The Infant-Derived Bifidobacterium bifidum Strain CNCM I-4319 Strengthens Gut Functionality
Martín, R., Bottacini, F., Egan, M., Chamignon, C., Tondereau, V., Moriez, R., Knol, J., Langella, P., Eutamène, H., Smokvina, T., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8091313 · Cited by 25
Li, L., Xiong, L., Yao, J., Zhuang, X., Zhang, S., Yu, Q., Xiao, Y., Cui, Y., & Chen, M. (2016) · Digestive and Liver Disease · doi:10.1016/j.dld.2016.05.002 · Cited by 25
Videlock, E. J., Mahurkar‐Joshi, S., Hoffman, J. M., Iliopoulos, D., Pothoulakis, C., Mayer, E. A., & Chang, L. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00288.2017 · Cited by 25
Yvon, S., Schwebel, L., Belahcen, L., Tormo, H., Peter, M., Haimoud-Lekhal, D. A., Eutamène, H., & Jard, G. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16642 · Cited by 25
Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases
Muehler, A. R., Slizgi, J. R., Kohlhof, H., Groeppel, M., Peelen, E., & Vitt, D. (2020) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v11.i6.114 · Cited by 25
Bravo-Vázquez, L. A., Medina-Ríos, I., Márquez-Gallardo, L. D., Reyes-Muñoz, J., Serrano‐Cano, F. I., Pathak, S., Banerjee, A., Bandyopadhyay, A., Duttaroy, A. K., & Paul, S. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07516-6 · Cited by 25
Annaházi, A., Dabek, M., Gecse, K. B., Salvador–Cartier, C., Polizzi, A., Rosztoczy, A. I., Róka, R., Theodorou, V., Wittmann, T., Bueno, L. P., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01805.x · Cited by 24
Zhou, Y., Ruan, Z., Zhou, L., Yang, Y., Mi, S., Deng, Z., & Yin, Y. (2016) · Food Science and Biotechnology · doi:10.1007/s10068-016-0037-3 · Cited by 24
Shokr, M. M., Eladawy, R. M., Azar, Y. O., & Raish, S. M. A. (2025) · Foods · doi:10.3390/foods14172926 · Cited by 25
Orock, A. M., Louwies, T., Ligon, C. O., Mohammadi, E., & Meerveld, B. G. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113841 · Cited by 23
Ludidi, S., Jonkers, D., Elamin, E., Pieters, H.-J. H. M., Schaepkens, E., Bours, P., Kruimel, J., Conchillo, J., & Masclee, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123498 · Cited by 25
Lessons Learnt from Post-Infectious IBS
Sarna, S. K. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00049 · Cited by 24
Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability
Ghouzali, I., Lemaître, C., Bahlouli, W., Azhar, S., Bôle‐Feysot, C., Méleine, M., Ducrotte, P. R., Déchelotte, P., & Coëffier, M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.08.010 · Cited by 23
Does stress induce bowel dysfunction?
Chang, Y.-M., Zaatari, M. E., & Kao, J. Y. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.911659 · Cited by 23
Oldroyd, P., Oldroyd, S., Meng, M. Y., Makwana, R., Sanger, G. J., Bulmer, D. C., Malliaras, G. G., & Owens, R. M. (2024) · Advanced Materials · doi:10.1002/adma.202312735 · Cited by 22
Kittana, M., Ahmadani, A., Al-Marzooq, F. I., & Attlee, A. (2021) · Nutrients · doi:10.3390/nu13113818 · Cited by 21
Intestinal permeability measurements: general aspects and possible pitfalls.
Teixeira, T. F. S., Moreira, A. P. B., Souza, N. C., Frías, R., & Pelúzio, M. D. C. G. (2014) · PubMed · doi:10.3305/nh.2014.29.2.7076 · Cited by 21
Chao, G., Wang, Y., Zhang, S., Yang, W., Ni, Z., & Zheng, X. (2017) · Oncotarget · doi:10.18632/oncotarget.20687 · Cited by 21
Boonma, P., Shapiro, J. M., Hollister, E. B., Badu, S., Wu, Q., Weidler, E. M., Abraham, B. P., Devaraj, S., Luna, R. A., Versalovic, J. A., et al. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.691689 · Cited by 20
Rastgoo, S., Ebrahimi‐Daryani, N., Agah, S., Karimi, S., Taher, M., Rashidkhani, B., Hejazi, E., Mohseni, F., Ahmadzadeh, M., Sadeghi, A., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.746703 · Cited by 20
Yadav, Y., Eslick, G. D., & Talley, N. J. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16624 · Cited by 23
Torres-Maravilla, E., Holowacz, S., Delannoy, J., Lenoir, L., Jacouton, E., Gervason, S., Meynier, M., Boucard, A.-S., Carvalho, F. A., Barbut, F., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-21746-8 · Cited by 20
O’Malley, D. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00272.2016 · Cited by 21
Ligon, C. O., Mohammadi, E., Ge, P., Hannig, G., Higgins, C. S., & Meerveld, B. G. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13375 · Cited by 20
Napier, B. A., Allegretti, J. R., Feuerstadt, P., Kelly, C. R., Hise, N. W. V., Jäger, R., Kassam, Z., & Reid, G. (2025) · Nutrients · doi:10.3390/nu17172734 · Cited by 26
Maqoud, F., Tricarico, D., Mallamaci, R., Orlando, A., & Russo, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311074 · Cited by 20
Valeur, J., Lind, R. A., Berstad, A., & Hatlebakk, J. (2013) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s45760 · Cited by 19
Localized colonic stem cell transplantation enhances tissue regeneration in murine colitis
Zhou, Q., Price, D. D., Dreher, K. L., Pronold, B., Callam, C. S., Sharma, J. P., & Verne, G. N. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01485.x · Cited by 19
Self-citationFang, W., Zhao, P., Shen, A., Liu, L., Chen, H., Chen, Y., Peng, J., Sferra, T. J., Sankararaman, S., Luo, Y., et al. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11844 · Cited by 19
He, X., Song, Z., Jiang, C., & Zhang, C.-F. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x1750094x · Cited by 18
Mihara, H., Boudaka, A., Tominaga, M., & Sugiyama, T. (2019) · Digestion · doi:10.1159/000504021 · Cited by 18
Effect of monoacylglycerol lipase inhibition on intestinal permeability in chronic stress model
Wang, J., Zhang, X., Yang, C., & Zhao, S. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.173 · Cited by 18
Li, X., Ren, K., Hong, X., Guo, S., Yu, S., & Yang, S. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15981 · Cited by 17
Metadata
- Authors
- Zhou, Q., Zhang, B., & Verne, N. G.
- Affiliations
- The Ohio State University (US)
- Cincinnati VA Medical Center (US)
- Corresponding author
- Verne, Nicholas G.
- Venue
- Pain
- Published
- 2009-11
- Volume
- 146
- Issue
- 1
- Pages
- 41-46
- ISSN
- 0304-3959 (ISSN-L)
- PMC
- PMC2763174
- OpenAlex
- W1967139826
- Cited by
- 373
- References
- 48
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 18 · 2023: 15 · 2022: 20 · 2021: 36 · 2020: 26 · 2019: 25 · 2018: 29 · 2017: 25 · 2016: 22 · 2015: 18 · 2014: 29 · 2013: 25 · 2012: 21
- FWCI
- 20.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS053090)
- National Center for Research Resources (M01RR000082)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- irritable bowel syndrome, diarrhea-predominant irritable bowel syndrome, intestinal permeability, visceral hypersensitivity, thermal hypersensitivity, lactulose/mannitol test, visceral pain, IBS symptom severity, gut-brain axis
- MeSH terms
- Adult, Catheterization, Cell Membrane Permeability, Diarrhea, Female, Hot Temperature, Humans, Hypersensitivity, Intestinal Mucosa, Male, Pain, Pain Measurement, Physical Stimulation, Severity of Illness Index, Irritable Bowel Syndrome
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