Migraine headaches and pain with neuropathic characteristics: Comorbid conditions in patients with multiple sclerosis
Open accessAbstract
We conducted a postal survey to assess the prevalence and characteristics of neuropathic pain and migraine in a cohort of multiple sclerosis (MS) patients. Of the 1300 questionnaires sent, 673 could be used for statistical analysis. Among the respondents, the overall pain prevalence in the previous month was 79%, with 51% experiencing pain with neuropathic characteristics (NCs) and 46% migraine. MS patients with both migraine and NC pain (32% of the respondents) reported more severe pain and had lower health-related quality of life than MS patients with either migraine or NC pain. Pain intensity in MS patients with migraine was moderate (6.0 ± 0.1). Migraine was mostly episodic, but headaches were occurring on ≥15 days per month in 15% of those with migraine. MS patients with migraine were younger and had shorter disease durations than those with NC pain. NC pain was most often located in the extremities, back and head, and was frequently described as tingling and pins-and-needles. The intensity of NC pain was low to moderate (4.9 ± 0.1), but positively correlated with the number of painful body sites. Nonetheless, patients with NC pain were more disabled (with a higher Expanded Disability Status Scale and pain interference index) than patients with migraine. Migraine, but not NC pain, was associated with age, disease duration, relapsing-remitting course, and interferon-beta treatment. This suggests that NC pain and migraine are mediated by different mechanisms. Therefore, pa…
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Sensitivity analysis removing individual outliers did not affect the overall conclusions for overall or possible neuropathic pain, yielding 18.8% (95% CI 15.0-22.7) and 17.6% (95% CI 13.2-22.0), indicating robustness of the results.
“The sensitivity analysis did not affect the overall conclusions of estimated prevalences after removing individual outliers (Feketová et al. 2017; Jallouli, Ghroubi, Ben Dhia, et al. 2025; Moisset et al. 2013), for either overall (18.8% [95% CI: 15.0; 22.7]) or possible (17.6% [95% CI: 13.2; 22.0]) neuropathic pain, indicating robustness of the results.”
From The Prevalence of Neuropathic Pain in Multiple Sclerosis—A Systematic Review and Meta‐Analysis Using the <scp>NeuPSIG</scp> Algorithm (2026) · cites this paper as Moisset et al. 2013
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No adjustments are needed for multiple comparisons.
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“The association was created in”
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Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study
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Central Pain in Patients with Multiple sclerosis
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BackgroundResultJungersen, R. C., Baccaro, V. K., Hvid, L. G., Dalgas, U., & Hoegh, M. (2026) · European Journal of Pain · doi:10.1002/ejp.70375 · Cited by 1 · see citing works
- Authors
- Moisset, X., Ouchchane, L., Guy, N., Bayle, D. J., Dallel, R., & Clavelou, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Corresponding author
- Moisset, Xavier
- ORCID
- Venue
- Pain
- Published
- 2013-12
- Volume
- 154
- Issue
- 12
- Pages
- 2691-2699
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2075378530
- Cited by
- 86
- References
- 6
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 2
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
- inserm.hal.science
- Licence
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- multiple sclerosis, migraine, neuropathic pain, comorbidities, pain prevalence, health-related quality of life, disability, Expanded Disability Status Scale, disease duration, pain mechanisms
- MeSH terms
- Adult, Female, France, Humans, Male, Middle Aged, Migraine Disorders, Multiple Sclerosis, Neuralgia, Surveys and Questionnaires, Cohort Studies, Comorbidity
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