Restless Legs Symptoms in Thyroid Disorders
Abstract
Dopaminergic dysfunction is associated with thyroid disorders and restless legs syndrome (RLS). In a 'face-to-face' interview, we evaluated for RLS using the diagnostic criteria of the International Restless Legs Syndrome Study Group (IRLSSG) in patients diagnosed biochemically with either hyper- or hypothyroidism, and in controls without thyroid disorders. Amongst 146 consecutive patients with biochemically confirmed thyroid disorders, none satisfied all the IRLSSG criteria of RLS, similar to the control population (0.2%, 1/434). However, we found 8.2% (12/146) with RLS-like symptoms (satisfied the first 3 IRLSSG criteria) compared to 0.9% (4/434) in the controls (p < 0.0001). Four (33.3%) of these patients reported complete resolution of these symptoms after treatment for their thyroid condition. In conclusion, while RLS-like symptoms were observed in some patients with thyroid disorders, our study demonstrates no significant difference of RLS prevalence between patients with thyroid disorders and euthyroid controls.
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In Tan et al.'s study, 12 patients (8.2%) with confirmed thyroid disorders had RLS-like symptoms, whereas only 4 control patients (0.9%) were similarly affected.
“Their study evaluated 146 patients with biochemically confirmed thyroid disorders and 434 control patients without thyroid disorders. Twelve patients (8.2%) with confirmed thyroid disorders had RLS-like symptoms, whereas only 4 control patients (0.9%) were similarly affected.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [21]
Tan et al. suggested that elevated levels of thyroid hormone can be an inciting stimulus for RLS-like symptoms, such as tremors, hyperkinetic states, and insomnia.
“Tan et al. (21) suggested that elevated levels of thyroid hormone can be an inciting stimulus for RLS-like symptoms, such as tremors, hyperkinetic states, and insomnia.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [21]
In Tan et al.'s study, of the 12 patients with thyroid disorders and RLS-like symptoms, 4 (33%) had complete resolution of RLS symptoms with adequate thyroid treatment.
“Furthermore, of the 12 patients with thyroid disorders and RLS-like symptoms, 4 (33%) had complete resolution of RLS symptoms with adequate thyroid treatment.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [21]
Tan et al. showed no significant difference in the prevalence of RLS between patients with and without thyroid dysfunction.
“Notably, they showed no significant difference in the prevalence of RLS between patients with and without thyroid dysfunction.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [21]
Cited by
Sorted by citations
Thyroid Dysfunction and Sleep Disorders
Green, M. E., Bernet, V., & Cheung, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.725829 · Cited by 103 · see citing works
Pradella-Hallinan, M., Pereira, J. C., & Martins, J. R. M. (2020) · Clinics · doi:10.6061/clinics/2020/e2140 · Cited by 5 · see citing works
- Authors
- Tan, E. K., Ho, S. C., Eng, P., Loh, L. M., Koh, L., Lum, S. Y., Teoh, M. L., Yih, Y., & Khoo, D.
- Affiliations
- SingHealth (SG)
- Singapore General Hospital (SG)
- Corresponding author
- Tan, E.K.
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 10
- Issue
- 3
- Pages
- 149-151
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2102782597
- Cited by
- 53
- References
- 0
- Citations by year
- 2025: 6 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- restless legs syndrome
- MeSH terms
- Adolescent, Adult, Aged, Ambulatory Care, Female, Humans, Male, Middle Aged, Prospective Studies, Restless Legs Syndrome, Thyroid Diseases
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