Restless Legs Syndrome, and Symptoms of Restless Syndrome in Patients With Graves' Disease: A Cross-Sectional Survey
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OBJECTIVES: Restless legs syndrome (RLS) is a frequent comorbid condition associated with distinct unrelated diseases. While the incidence of RLS has not been definitively confirmed, RLS-like symptoms have been reported in a section of Asian population who also had hyperthyroidism. The prevalence of RLS is generally low in Asian populations. Under these circumstances, we hypothesized that in a population where RLS is common, such as in Brazil, RLS could manifest as a comorbid ailment alongside Graves' disease, a common hyperthyroid condition. METHODS: In a cross-sectional survey, 108 patients who presented with Graves' disease were analyzed for restless legs or associated symptoms. RESULTS: Twelve patients (11.1%) displayed symptoms of RLS prior to the incidence of Graves' disease. These patients experienced worsening of the symptoms during their hyperthyroid state. Six patients (5.6%) developed RLS, consequent upon the incidence of Graves' disease as per the consensus of the panel of the experts. Fifteen patients (13.9%) also presented with RLS-like symptoms without any discernible circadian feature of the syndrome. CONCLUSION: Our findings confirm that Graves' disease might trigger restless legs-like symptoms, while the condition of hyperthyroidism could also be complicated by definite RLS.
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Pradella-Hallinan et al. showed that patients with RLS and subsequent Graves disease had worsening of their RLS symptoms during the hyperthyroid state.
“Pradella-Hallinan et al. (24) showed that patients with RLS and subsequent Graves disease had worsening of their RLS symptoms during the hyperthyroid state.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [24]
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- Authors
- Pradella-Hallinan, M., Pereira, J. C., & Martins, J. R. M.
- Affiliations
- Faculdade de Medicina de Jundiaí (BR)
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Pereira, José Carlos
- Venue
- Clinics
- Publisher
- Elsevier BV
- Published
- 2020
- Volume
- 75
- Pages
- e2140
- ISSN
- 1807-5932 (ISSN-L)
- PMC
- PMC7603292
- OpenAlex
- W3105338784
- Cited by
- 5
- References
- 31
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- restless legs syndrome, Graves' disease, hyperthyroidism, comorbidities, prevalence, Brazilian patients
- MeSH terms
- Anxiety, Brazil, Cross-Sectional Studies, Graves Disease, Humans, Restless Legs Syndrome, Prevalence
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