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Cited by 127Parkinson's Disease Mechanisms and TreatmentsFatty Acid Research and HealthNutritional Studies and Diet

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Dietary fat intake, pesticide use, and Parkinson's disease

Open access
Kamel, Freya, Goldman, Samuel M., Umbach, David M., Chen, Honglei, Richardson, Gina, Barber, Marie Richards, Meng, Cheryl, Marras, Connie, Korell, Monica, Kasten, Meike, Hoppin, Jane A., Comyns, Kathleen, Chade, Anabel, Blair, Aaron, Bhudhikanok, Grace S., Webster Ross, G., William Langston, J., Sandler, Dale P., Tanner, Caroline M.·2014·Parkinsonism & Related Disorders
DOI 10.1016/j.parkreldis.2013.09.023PMC PMC3936597
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Abstract

Background Dietary fat intake may modify Parkinson's disease (PD) risk directly or by altering the response to environmental neurotoxicants including pesticides.Methods We conducted a case-control study of PD nested in the Agricultural Health Study (AHS), a cohort of pesticide applicators and spouses. We evaluated diet and pesticide use before diagnosis in 89 PD cases, confirmed by movement disorder specialists, or a corresponding date in 336 frequency-matched controls. Associations were evaluated using multivariate logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs).Results In the AHS, PD was inversely associated with N-3 polyunsaturated fatty acids (PUFAs) (OR 0.4, 95% CI 0.2-0.8 for highest vs. lowest tertile) and the N-3 precursor α-linolenic acid (0.4, 0.2-0.8). In a meta-analysis of nine studies, including the present one, PD was inversely associated with α-linolenic acid (0.81, 0.68-0.96). In the AHS, associations of PD with the pesticides paraquat and rotenone were modified by fat intake. The OR for paraquat was 4.2 (1.5-12) in individuals with PUFA intake below the median but 1.2 (0.4-3.4) in those with higher intake (p-interaction = 0.10). The OR for rotenone was 5.8 (2.3-15) in those with saturated fat intake above the median but 1.5 (0.5-4.2) in those with lower intake (p-interaction = 0.02).Conclusions PUFA intake was consistently associated with lower PD risk, and dietary fats modified the association of PD risk with pesticide exposure. If confirmed, these findings suggest that a diet high in PUFAs and low in saturated fats might reduce risk of PD.

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Authors
Kamel, F., Goldman, S. M., Umbach, D. M., Chen, H., Richardson, G., Barber, M. R., Meng, C., Marras, C., Korell, M., Kasten, M., Hoppin, J. A., Comyns, K., Chade, A., Blair, A., Bhudhikanok, G. S., Webster Ross, G., William Langston, J., Sandler, D. P., & Tanner, C. M.
Affiliations
  • National Institutes of Health (US)
  • Parkinson's Institute and Clinical Center (US)
  • University of Toronto (CA)
  • University of Lübeck (DE)
  • Favaloro University (AR)
  • United States Department of Health and Human Services (US)
Corresponding author
Kamel, Freya
ORCID
Venue
Parkinsonism & Related Disorders
Publisher
Elsevier BV
Published
2014-01
Volume
20
Issue
1
Pages
82-87
ISSN
1353-8020 (ISSN-L)
DOI
10.1016/j.parkreldis.2013.09.023
PMC
PMC3936597
OpenAlex
W2058530978
Cited by
127
References
35
Citations by year
2026: 7 · 2025: 7 · 2024: 5 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 11 · 2019: 17 · 2018: 8 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 10
FWCI
1.48
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Parkinsonism & Related Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • NIEHS (R01-ES10803)
  • National Institute of Environmental Health Sciences (Z01-ES044007, Z01-ES049030)
  • National Cancer Institute grant (Z01-CP010119)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
Parkinson's disease, dietary fat intake
MeSH terms
Adult, Aged, Aged, 80 and over, Diet, Dietary Fats, Female, Humans, Male, Middle Aged, Parkinson Disease, Pesticides, Risk Factors, Fatty Acids, Omega-3, Case-Control Studies

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