Strigolactone signalling: standing on the shoulders of DWARFs
Abstract
Strigolactones are an ancient and major class of endogenous plant growth regulators. Although only recently identified, rapid progress has been made in understanding strigolactone biology, including the identification of a signalling pathway involving DWARF14 α/β-fold proteins, the SCF(MAX2) ubiquitin ligase and SMAX1-LIKE (SMXL) family of chaperonin-like proteins. Several rapid effects of strigolactone signalling have also been identified, including endocytosis of the PIN-FORMED1 (PIN1) auxin efflux carrier and transcript accumulation of the BRANCHED1 (BRC1) transcription factor. Here we assess our current knowledge of strigolactone signalling, and discuss how increased understanding of the cell biology of the system can help to resolve some of the current uncertainties in the field.
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A possible Arabidopsis ortholog of D53 is SMXL7.
“A possible Arabidopsis ortholog of D53 is SUPPRESSOR OF MORE AXILLARY GROWTH2 LIKE 7 (SMXL7; Stanga et al., 2013; Bennett and Leyser, 2014; Table 1).”
From Shaping plant architecture (2015) · cites this paper as Bennett and Leyser, 2014
D53 emerges as the genuine SL pathway repressor.
“While interaction of MAX2 with DELLA proteins and BES1 may point to cross talk with the gibberellic acid and brassinosteroid pathway, respectively, D53 emerges as the genuine SL pathway repressor (reviewed in Bennett and Leyser, 2014).”
From Shaping plant architecture (2015) · cites this paper as Bennett and Leyser, 2014
D14 may interact with the F-box protein MAX2 upon SL binding, leading to ubiquitination-mediated degradation of a SL signaling repressor.
“This indicates that in analogy to other plant hormone signaling pathways, D14 may interact with the F-box protein MAX2 upon SL binding, leading to ubiquitination-mediated degradation of a SL signaling repressor (Bennett and Leyser, 2014).”
From Shaping plant architecture (2015) · cites this paper as Bennett and Leyser, 2014
Cites
<i>MAX1</i> and <i>MAX2</i> control shoot lateral branching in <i>Arabidopsis</i>
Stirnberg, P., van de Sande, K., & Leyser, H. M. O. (2002) · Development · doi:10.1242/dev.129.5.1131 · Cited by 692 · see citing works
Strigolactones affect lateral root formation and root-hair elongation in Arabidopsis
Kapulnik, Y., Delaux, P.-M., Resnick, N., Mayzlish-Gati, E., Wininger, S., Bhattacharya, C., Séjalon-Delmas, N., Combier, J.-P., Bécard, G., Belausov, E., et al. (2011) · Planta · doi:10.1007/s00425-010-1310-y · Cited by 502 · see citing works
The Pea TCP Transcription Factor PsBRC1 Acts Downstream of Strigolactones to Control Shoot Branching
Braun, N., de Saint Germain, A., Pillot, J.-P., Boutet-Mercey, S., Dalmais, M., Antoniadi, I., Li, X., Maia-Grondard, A., Le Signor, C., Bouteiller, N., et al. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.182725 · Cited by 486 · see citing works
Strigolactones enhance competition between shoot branches by dampening auxin transport
Crawford, S., Shinohara, N., Sieberer, T., Williamson, L., George, G., Hepworth, J., Müller, D., Domagalska, M. A., & Leyser, O. (2010) · Development · doi:10.1242/dev.051987 · Cited by 384 · see citing works
Self-citationMolecular mechanism of strigolactone perception by DWARF14
Nakamura, H., Xue, Y.-L., Miyakawa, T., Hou, F., Qin, H.-M., Fukui, K., Shi, X., Ito, E., Ito, S., Park, S.-H., et al. (2013) · Nature Communications · doi:10.1038/ncomms3613 · Cited by 378 · see citing works
Wang, Y., Sun, S., Zhu, W., Jia, K., Yang, H., & Wang, X. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.11.010 · Cited by 319 · see citing works
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Multiple pathways regulate shoot branching
Rameau, C., Bertheloot, J., Leduc, N., Andrieu, B., Foucher, F., & Sakr, S. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00741 · Cited by 357 · see citing works
Teichmann, T., & Muhr, M. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00233 · Cited by 228 · see citing works
“Within 6 years after the first description of SLs as branching hormones, further key components of SL signaling have been identified and a tentative scaffold of the signal transduction pathway has been assembled (Bennett and Leyser, 2014; Waldie et al., 2014).”
BackgroundInfluential
- Authors
- Bennett, T., & Leyser, O.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Leyser, Ottoline
- Venue
- Current Opinion in Plant Biology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 22
- Pages
- 7-13
- ISSN
- 1369-5266 (ISSN-L)
- OpenAlex
- W2043139676
- Cited by
- 95
- References
- 6
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 14 · 2016: 17 · 2015: 12 · 2014: 3
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Plant Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gatsby Foundation (GAT3272C)
- European Research Council (294514)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- strigolactone signalling, DWARF14, plant growth regulators, auxin transport
- MeSH terms
- Lactones, Arabidopsis, Gene Expression Regulation, Plant, Arabidopsis Proteins
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