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Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why?
Open accessAbstract
Although GABAA receptors are widely distributed at inhibitory synapses on dendrites and cell bodies of neurons, they also occur in other places, in particular at synapses made on axons and in extrasynaptic membranes. This review summarises some of the evidence that presynaptic receptors modulate transmission not only at primary afferents in the spinal cord, but also at a variety of sites in the brain, including hippocampal mossy fibres. These receptors modulate transmitter release via several different mechanisms. Another form of unconventional GABAA receptor-mediated signalling is the mediation of a tonic conductance, seen in granule cells of the cerebellum and dentate gyrus and also in hippocampal interneurons. Tonic signalling appears to be mediated by extrasynaptic receptors. The adaptive significance of this form of signalling remains poorly understood.
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Citations
Cited by
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759
GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses
Luscher, B., Fuchs, T., & Kilpatrick, C. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.024 · Cited by 434
Regulation of cortical microcircuits by unitary GABA-mediated volume transmission
Oláh, S., Füle, M., Komlósi, G., Varga, C., Báldi, R., Barzó, P., & Tamás, G. (2009) · Nature · doi:10.1038/nature08503 · Cited by 386
Deidda, G., Bozarth, I. F., & Cancedda, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00119 · Cited by 192
Metadata
- Authors
- Kullmann, D. M., Ruiz, A., Rusakov, D. M., Scott, R., Semyanov, A., & Walker, M. C.
- Venue
- Progress in Biophysics and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 87
- Issue
- 1
- Pages
- 33-46
- ISSN
- 0079-6107 (ISSN-L)
- OpenAlex
- W2013394850
- Cited by
- 222
- References
- 0
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kullmann, D. M., Ruiz, A., Rusakov, D. M., Scott, R., Semyanov, A., & Walker, M. C. (2005). Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why? Progress in Biophysics and Molecular Biology. https://doi.org/10.1016/j.pbiomolbio.2004.06.003
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