The DOI matches its Crossref record; 310 of the 310 references it cites were found in a registry or an index.
GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses
Open accessAbstract
Proper developmental, neural cell type-specific and activity-dependent regulation of GABAergic transmission is essential for virtually all aspects of CNS function. The number of GABAA receptors in the postsynaptic membrane directly controls the efficacy of GABAergic synaptic transmission. Thus, regulated trafficking of GABAA receptors is essential for understanding of brain function in both health and disease. Here we summarize recent progress in understanding of mechanisms that allow dynamic adaptation of cell surface expression and postsynaptic accumulation and function of GABAA receptors. This includes activity-dependent and cell type-specific changes in subunit gene expression, assembly of subunits into receptors, as well as exocytosis, endocytic recycling, diffusion dynamics and degradation of GABAA receptors. In particular, we focus on the roles of receptor-interacting proteins, scaffold proteins, synaptic adhesion proteins, and enzymes that regulate the trafficking and function of receptors and associated proteins. In addition, we review neuropeptide signaling pathways that affect neural excitability through changes in GABAAR trafficking.
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Metadata
- Authors
- Luscher, B., Fuchs, T., & Kilpatrick, C. L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 70
- Issue
- 3
- Pages
- 385-409
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2033129564
- Cited by
- 434
- References
- 310
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Luscher, B., Fuchs, T., & Kilpatrick, C. L. (2011). GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses. Neuron. https://doi.org/10.1016/j.neuron.2011.03.024
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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