Cited by 125Cardiac electrophysiology and arrhythmiasConnexins and lens biologyCardiac Arrhythmias and Treatments

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Influence of anisotropic conduction properties in the propagation of the cardiac action potential

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Valderrábano, Miguel·2007·Progress in Biophysics and Molecular Biology

DOI 10.1016/j.pbiomolbio.2007.03.014PMC PMC1995420

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Abstract

Anisotropy, the property of being directionally dependent, is ubiquitous in nature. Propagation of the electrical impulse in cardiac tissue is anisotropic, a property that is determined by molecular, cellular, and histological determinants. The properties and spatial arrangement of connexin molecules, the cell size and geometry, and the fiber orientation and arrangement are examples of structural determinants of anisotropy. Anisotropy is not a static property but is subject to dynamic functional regulation, mediated by modulation of gap junctional conductance. Tissue repolarization is also anisotropic. The relevance of anisotropy extends beyond normal propagation and has important implications in pathological states, as a potential substrate for abnormal rhythms and reentry.

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Authors: Valderrábano, M.
Affiliations: Houston Methodist (US)
Corresponding author: Valderrábano, Miguel
ORCID: Valderrábano, Miguel
Venue: Progress in Biophysics and Molecular Biology
Publisher: Elsevier BV
Published: 2007-05
Volume: 94
Issue: 1-2
Pages: 144-168
ISSN: 0079-6107 (ISSN-L)
DOI: 10.1016/j.pbiomolbio.2007.03.014
PMC: PMC1995420
OpenAlex: W2015162683
Cited by: 125
References: 110
Citations by year: 2026: 2 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 11 · 2021: 10 · 2020: 17 · 2019: 10 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 3
FWCI: 0.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5004 d)
Locations: Progress in Biophysics and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r21hl085215-02)
National Heart, Lung, and Blood Institute (R21-HL085215)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: cardiac anisotropy, cardiac action potential propagation, gap junction conductance, connexins, fiber orientation, reentry, cardiac arrhythmias, cardiac tissue electrophysiology
MeSH terms: Action Potentials, Animals, Computer Simulation, Electric Conductivity, Heart Conduction System, Humans, Models, Cardiovascular, Cardiomyopathies, Anisotropy, Connexins, Myocytes, Cardiac

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Influence of anisotropic conduction properties in the propagation of the cardiac action potential

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