The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Influence of anisotropic conduction properties in the propagation of the cardiac action potential
Open accessAbstract
Anisotropy, the property of being directionally dependent, is ubiquitous in nature. Propagation of the electrical impulse in cardiac tissue is anisotropic, a property that is determined by molecular, cellular, and histological determinants. The properties and spatial arrangement of connexin molecules, the cell size and geometry, and the fiber orientation and arrangement are examples of structural determinants of anisotropy. Anisotropy is not a static property but is subject to dynamic functional regulation, mediated by modulation of gap junctional conductance. Tissue repolarization is also anisotropic. The relevance of anisotropy extends beyond normal propagation and has important implications in pathological states, as a potential substrate for abnormal rhythms and reentry.
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“In healthy tissues, action potentials propagate faster in the direction of cell alignment, with myocytes showing slower conduction velocities (CVs) in the transverse direction (33).”
From Recreating the heart's helical structure-function relationship with focused rotary jet spinning (2022) · cites this paper as [33]
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Metadata
- Authors
- Valderrábano, M.
- Affiliations
- Houston Methodist (US)
- Corresponding author
- Valderrábano, Miguel
- ORCID
- Valderrábano, Miguel
- Venue
- Progress in Biophysics and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 94
- Issue
- 1-2
- Pages
- 144-168
- ISSN
- 0079-6107 (ISSN-L)
- PMC
- PMC1995420
- OpenAlex
- W2015162683
- Cited by
- 125
- References
- 110
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 11 · 2021: 10 · 2020: 17 · 2019: 10 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Progress in Biophysics and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r21hl085215-02)
- National Heart, Lung, and Blood Institute (R21-HL085215)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- cardiac anisotropy, cardiac action potential propagation, gap junction conductance, connexins, fiber orientation, reentry, cardiac arrhythmias, cardiac tissue electrophysiology
- MeSH terms
- Action Potentials, Animals, Computer Simulation, Electric Conductivity, Heart Conduction System, Humans, Models, Cardiovascular, Cardiomyopathies, Anisotropy, Connexins, Myocytes, Cardiac
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