Reproductive Complications in Childhood Cancer Survivors
Open accessAbstract
Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.
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Fertility is most impaired by alkylators and more so in males than in females.
“Generally, fertility is most impaired by alkylators and more so in males than in females 175 .”
From Osteosarcoma (2022) · cites this paper as [175]
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Colino, C. G., Urdiales, P. G., Honrubia, A. M., Acosta, M. J. O., & Abos, M. G. (2023) · Anales de Pediatría · doi:10.1016/j.anpedi.2023.09.018 · Cited by 1 · see citing works
Description and Management of Radiotherapy-Induced Long-Term Effects
Vogin, G. (2021) · Springer eBooks · doi:10.1007/978-3-030-78648-9_13 · Cited by 1 · see citing works
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Self-citationA 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test
Touwslager, R. N. H., Zwaan, C. M., Bakker, B., Lentjes, E. G. W. M., Looijenga, L. H. J., & van Santen, H. M. (2024) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2024-0019
Souza, R. M., Moreira, V. D. S., Souza, N. V. D. D. O., Peres, P. L. P., Marins, A. L. C., de Almeida, L. F., Rocha, R. S., Padilha, R. A., & de Andrade, K. B. S. (2024) · doi:10.22533/at.ed.4722410057
Mazzoni, V. G., Marcellini, P. S., Carvalho, E. C., Muzi, C. D., de Mello, L. R. G., Marins, A. L. C., Carvalho, A. F. C., de Mesquita, A. M. F., Stipp, M. A. C., & de Andrade, K. B. S. (2024) · doi:10.22533/at.ed.47224100511
O MANEJO DA DOR PELA EQUIPE DE ENFERMAGEM NA ONCOLOGIA PEDIÁTRICA: UMA REVISÃO DE LITERATURA
da Silva, H. S., Varella, T. C. M. Y. M. L., Peres, P. L. P., Souza, N. V. D. D. O., Soares, S. S. S., de Farias, S. N. P., Monteiro, J. L. D. S., Pinheiro, A. P. B., de Almeida, C. G., Carvalho, E. C., et al. (2024) · doi:10.22533/at.ed.4722410051
EXENTERAÇÃO PÉLVICA EM PACIENTES COM CÂNCER GINECOLÓGICO
da Silva, D. A., Resende, R. I., Júnior, J. D. J. C., Muzi, C. D., Frias, T. F. P., Lima, V. C. G. S., Lopes, S. M., Pedrada, L. D. S. D. A., Padilha, R. A., & de Andrade, K. B. S. (2024) · doi:10.22533/at.ed.47224100510
HIPODERMÓCLISE EM PACIENTES ONCOLÓGICOS SOB CUIDADOS PALIATIVOS
Ramos, A. D. V., Sardou, M., Leite, D. C., Camerini, F. G., Peres, E. M., Assad, L. G., Sbano, C. P., Lima, V. C. G. S., de Menezes, R. F., Pires, A. D. S., et al. (2024) · doi:10.22533/at.ed.4722410055
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INCIDÊNCIA DE CÂNCER EM PESSOAS COM SÍNDROME DE DOWN: UM ESTUDO BIBLIOMÉTRICO
Cunha, T. F., Silva, A. O. D. C. E., Sampaio, C. E. P., Pinheiro, A. P. B., de Mello, L. R. G., Marins, A. L. C., dos Santos, R. O. M., Franco, A. S., de Paula, V. G., Neto, N. G. M. G., et al. (2024) · doi:10.22533/at.ed.4722410059
ABORDAGEM DOS CUIDADOS PALIATIVOS NO LINFOMA NÃO HODGKIN: UMA REVISÃO INTEGRATIVA
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REPERCUSSÕES DO CÂNCER INFANTOJUVENIL: UMA REVISÃO INTEGRATIVA
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Chemotherapy and Male Reproduction
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Chen, C., Huang, J., Chen, R., Lv, M., Huang, M., Guo, L., & Lin, Y. (2026) · European Journal of Cancer Care · doi:10.1155/ecc/7668282
Stukaitė-Ruibienė, E., Clasen, N. H. Z., van den Heuvel‐Eibrink, M. M., & Rascon, J. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1925381
Ovarian function and fertility after childhood cancer: risk assessment in the era of novel therapies
Diallo, S., Cazian, A., Devalck, C., & Demeestere, I. (2026) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2026.106046
- Authors
- van Santen, H. M., van de Wetering, M. D., Bos, A. M. E., vd Heuvel-Eibrink, M. M., van der Pal, H. J., & Wallace, W. H.
- Affiliations
- University Medical Center Utrecht (NL)
- Royal Hospital for Sick Children (GB)
- Venue
- Pediatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 67
- Issue
- 6
- Pages
- 1187-1202
- ISSN
- 0031-3955 (ISSN-L)
- OpenAlex
- W3094877357
- Cited by
- 42
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 21 · 2023: 6 · 2022: 4 · 2021: 4
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Pediatric Clinics of North America (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- Ferring
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- childhood cancer survivors, gonadal dysfunction, infertility, gonadal damage, fertility preservation, gonadotoxicity, reproductive complications, pregnancy after cancer treatment, pubertal development, linear growth, sexual function
- MeSH terms
- Cancer Survivors, Antineoplastic Agents, Child, Child Development, Female, Genital Diseases, Female, Genital Diseases, Male, Humans, Male, Neoplasms, Radiotherapy, Drug-Related Side Effects and Adverse Reactions
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