Topical 5-aminolevulinic acid-mediated photodynamic therapy for basal cell carcinoma
Abstract
Topical 5-aminolevulinic acid-mediated photodynamic therapy is an established approach for the treatment of basal cell carcinoma. This study with 5- aminolevulinic acid drug Levulon was conducted in patients with superficial skin basal cell carcinoma. The study included 82 patients with overall number of tumor foci of 119. Tumor sites were as follows: head and neck, trunk, extremities.A total of two photodynamic therapy sessions, four weeks apart were performed using a laser with a wavelength of 630 nm and energy density of 350 J/cm 2. A complete response was recorded in 77 patients (114 foci) with an excellent cosmetic result. According to the analysis of survival in the group of patients with a complete response, the overall RFS was as follows: 1-year rate - 92.1 %, 3-year - 88.3 %. Photodynamic therapy with topical Levulon in patients with superficial BCC of the skin was effective and safe.
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The majority of published work on PDT for nonmelanoma skin cancers has studied efficacy in people with FST I-II.
“Where PDT has been used to treat nonmelanoma skin cancers, including BCC, SCC, Bowen’s disease, and AK, the majority of the published work has studied efficacy in people with FST I–II.112,122–125”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [122]
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Photodynamic therapy for basal cell carcinoma of the nose and auricles
Николаевич, В. В., Lipova, E. V., Stranadko, E. F., Karasev, E., Vitvitskaya, Y. G., Kagoiancz, R., & Глазко, И. И. (2026) · Vrach · doi:10.29296/25877305-2026-01-04
- Authors
- Filonenko, E., Kaprin, A., Urlova, A., Grigorievykh, N., & Ivanova-Radkevich, V.
- Affiliations
- Ministry of Health of the Russian Federation (RU)
- Venue
- Photodiagnosis and Photodynamic Therapy
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 30
- Pages
- 101644
- ISSN
- 1572-1000 (ISSN-L)
- OpenAlex
- W3005988721
- Cited by
- 16
- References
- 12
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photodiagnosis and Photodynamic Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- photodynamic therapy, 5-aminolevulinic acid, basal cell carcinoma, superficial skin cancer, topical treatment, 630 nm laser, recurrence-free survival, cosmetic outcome, treatment safety
- MeSH terms
- Administration, Topical, Aminolevulinic Acid, Basal Cell Carcinoma, Carcinoma, Basal Cell, Humans, Photochemotherapy, Skin Neoplasms, Photosensitizing Agents
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