Adherence profiles in kidney transplant patients: Causes and consequences
Open accessAbstract
OBJECTIVE: Adherence is a dynamic phenomenon and a critical determinant of transplant patients outcome. The objective of this longitudinal study was to explore adherence in kidney transplant patients followed-up for up to three years after transplantation. METHODS: Adherence was repeatedly estimated using the Morisky-Green-Levine 4-Item Medication Adherence Scale, in two successive cohorts of 345 (EPIGREN) and 367 (EPHEGREN) kidney transplant recipients. Mixed effect modeling with latent processes and latent classes was used to describe adherence time-profiles. RESULTS: ), which worsened over time. Good adherence was associated with age >50 years, fewer depression episodes (5% vs. 13%, p = 0.001) and a better mental health component of quality of life (MCS-SF36 47 ± 11 vs. 41 ± 13, p = 0.015). Survival without acute rejection episodes was longer in the adherent class (p = 0.004). CONCLUSIONS: The risk of poor adherence in renal transplant patients can be detected as early as one month post-transplantation, using appropriate and easy tools adapted to routine monitoring. PRACTICE IMPLICATIONS: An early focus on vulnerable patients should allow putting into place actions in order to reduce the risk of poor outcome related to poor adherence.
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Younger age, depression and anxiety, using avoidance as an adaptation strategy, and inability to communicate emotions and emotional dysregulation are factors predisposing to poor medication adherence in transplant patients.
“Younger age, depression and anxiety, using avoidance as an adaptation strategy, and the inability to communicate emotions and emotional dysregulation represent some of the factors predisposing to poor medication adherence in transplant patients [3,11,12].”
From Effectiveness of Expressive Writing in Kidney Transplanted Patients: A Randomized Controlled Trial Study (2022) · cites this paper as [12]
The Introduction and Discussion identify younger age and depression as factors associated with poor adherence, and §3.3 reports that younger recipients were more likely to be in the non-adherent group. The paper does not identify anxiety, avoidance as a coping strategy, difficulty communicating emotions, or emotional dysregulation as predisposing factors for poor medication adherence. (LLM, conf=0.86)
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Pierro, L., Servidei, G., Pretagostini, R., Stabile, D., Nudo, F., Lai, S., Aceto, P., Poli, L., Fazzari, E., & Lai, C. (2022) · Healthcare · doi:10.3390/healthcare10081559 · Cited by 8 · see citing works
“Younger age, depression and anxiety, using avoidance as an adaptation strategy, and the inability to communicate emotions and emotional dysregulation represent some of the factors predisposing to poor medication adherence in transplant patients [3,11,12].”
Background
- Authors
- Villeneuve, C., Rousseau, A., Rerolle, J.-P., Couzi, L., Kamar, N., Essig, M., Etienne, I., Westeel, P.-F., Büchler, M., Esposito, L., Thierry, A., Marquet, P., & Monchaud, C.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Université de Tours (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Corresponding author
- Villeneuve, Claire
- ORCID
- Venue
- Patient Education and Counseling
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 103
- Issue
- 1
- Pages
- 189-198
- ISSN
- 0738-3991 (ISSN-L)
- OpenAlex
- W2966625712
- Cited by
- 53
- References
- 56
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 10 · 2023: 17 · 2022: 6 · 2021: 5 · 2020: 4
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Patient Education and Counseling (acceptedVersion, other-oa)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc)
- Funders
- Agence de la Biomédecine
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- medication adherence, kidney transplant recipients, depression, mental health, quality of life, acute rejection, post-transplant monitoring, latent class analysis
- MeSH terms
- Humans, Immunosuppressive Agents, Longitudinal Studies, Middle Aged, Quality of Life, Kidney Transplantation, Medication Adherence
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