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Cited by 46Cytomegalovirus and herpesvirus researchHerpesvirus Infections and TreatmentsViral-associated cancers and disorders

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Primary Human Herpesvirus-6 Infection in the Central Nervous System Can Cause Severe Disease

Mannonen, Laura, Herrgård, Eila, Valmari, Pekka, Rautiainen, Paula, Uotila, Kari, Aine, Marjo-Riitta, Karttunen-Lewandowski, Pirkko, Sankala, Juhani, Wallden, Tiina, Koskiniemi, Marjaleena·2007·Pediatric Neurology
DOI 10.1016/j.pediatrneurol.2007.05.011
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Abstract

Human herpesvirus-6 (HHV-6) infection is common in infancy, and symptoms are usually mild. However, encephalitis and other neurologic complications have been reported. Primary HHV-6 infection has been rarely confirmed in the central nervous system. We studied 21 children with suspected HHV-6 infection, drawn from a prospective, large-scale study of neurologic infections in Finland. Human herpesvirus-6 polymerase chain reaction was performed on cerebrospinal fluid samples, and antibody tests were performed on serum and cerebrospinal fluid. We identified nine children, aged 3 to 24 months, who had HHV-6-specific nucleic acid in cerebrospinal fluid. Primary infection was confirmed by seroconversion of specific antibodies in six, whereas one had a fourfold increase, and one had a fourfold decrease, in the antibody titer supporting recent infection. Generalized and prolonged seizures appeared in six children, four had a rash, four had ataxia, and four had gastroenteritis. All but two had a high fever. At follow-up, four children had evident neurologic sequelae, ataxia, and developmental disability, and needed special education. Primary HHV-6 infection may invade the central nervous system, and can cause neurologic symptoms and potentially permanent disability in children aged <or=2 years. The possibility of HHV-6 infection must be considered when treating acutely ill children, and especially those with convulsions.

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Crossref · 10.1016/j.pediatrneurol.2007.05.011

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  • HHV-6 can cause severe CNS disease, especially in immunocompromised hosts, but a positive HHV-6 finding may also result from subclinical reactivation of the latent virus or chromosomal integration and may not be relevant for the CNS infection.

    “Although HHV-6 can cause severe CNS disease, especially in immunocompromised hosts, a positive HHV-6 finding may also result from subclinical reactivation of the latent virus or chromosomal integration and may not be relevant for the CNS infection (26–29).”

    From Evaluation of the Novel CE-IVD-Marked Multiplex PCR QIAstat-Dx Meningitis/Encephalitis Panel (2023) · cites this paper as [26]

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Metadata

Authors
Mannonen, L., Herrgård, E., Valmari, P., Rautiainen, P., Uotila, K., Aine, M.-R., Karttunen-Lewandowski, P., Sankala, J., Wallden, T., & Koskiniemi, M.
Affiliations
  • University of Helsinki (FI)
  • Kuopio University Hospital (FI)
  • Lapland Central Hospital (FI)
  • Kanta-Hämeen Keskussairaala (FI)
  • Savonlinna Central Hospital (FI)
  • Kymenlaakson keskussairaala (FI)
Corresponding author
Mannonen, Laura
ORCID
Venue
Pediatric Neurology
Publisher
Elsevier BV
Published
2007-09
Volume
37
Issue
3
Pages
186-191
ISSN
0887-8994 (ISSN-L)
DOI
10.1016/j.pediatrneurol.2007.05.011
OpenAlex
W1984235860
Cited by
46
References
1
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 4
FWCI
2.53
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pediatric Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
human herpesvirus 6, central nervous system infection, encephalitis, neurological complications, infants, cerebrospinal fluid viral detection, seroconversion, seizures, ataxia, developmental disabilities, neurological sequelae
MeSH terms
Ataxia, Developmental Disabilities, DNA, Viral, Female, Finland, Humans, Infant, Male, Seizures, Serologic Tests, Cohort Studies, Herpesvirus 6, Human, Polymerase Chain Reaction, Roseolovirus Infections, Central Nervous System Viral Diseases

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