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Cited by 95Cytomegalovirus and herpesvirus researchViral-associated cancers and disordersHerpesvirus Infections and Treatments

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children

Caserta, Mary T., McDermott, Michael P., Dewhurst, Stephen, Schnabel, Kenneth, Carnahan, Jennifer A., Gilbert, Lynne, Lathan, Gladys, Lofthus, Geraldine K., Hall, Caroline B.·2004·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2004.06.016
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Abstract

Objective To determine in healthy children after primary infection the persistence of human herpesvirus 6 (HHV6) DNA, the presence and frequency of HHV6 re-activation or re-infection, and the relationship of both to illness and the presence of human herpesvirus 7 (HHV7) infection.Study design Children 1 to 12 years of age with previous HHV6 infection were prospectively evaluated by HHV6 and HHV7 DNA polymerase chain reaction (PCR) and reverse transcription (RT)-PCR for HHV6. HHV6 plasma antibody titers were measured. Illnesses were recorded by diary, and physician records were reviewed.Results HHV6 DNA was detected in >or=1 peripheral blood mononuclear cell (PBMC) samples in 89% of children. HHV6 reactivation and re-infection were detected by RT-PCR in 1.1% of samples. Detection of HHV6 DNA was intermittent in 76% of children and was not associated with cumulative rates of illness. Illness at a study visit was significantly associated with the absence of HHV6 and HHV7 DNA in PBMC samples and was not associated with HHV6 antibody titer or the presence of HHV6 DNA in saliva.Conclusions HHV6 DNA persists in most children intermittently following primary infection and is unrelated to illness. Reactivation of HHV6 occurs in healthy children without apparent illness.

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Crossref · 10.1016/j.jpeds.2004.06.016

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Metadata

Authors
Caserta, M. T., McDermott, M. P., Dewhurst, S., Schnabel, K., Carnahan, J. A., Gilbert, L., Lathan, G., Lofthus, G. K., & Hall, C. B.
Affiliations
University of Rochester Medicine (US)
Corresponding author
Caserta, Mary T.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2004-10
Volume
145
Issue
4
Pages
478-484
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2004.06.016
OpenAlex
W2084821388
Cited by
95
References
23
Citations by year
2025: 4 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 6
FWCI
5.27
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (R02 AI 33020-02)
  • National Center for Research Resources (5-M01-RR-00044, M01RR000044)
Topics
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Keywords
human herpesvirus 6, viral DNA persistence, primary infection, healthy children, peripheral blood mononuclear cells, plasma antibodies, saliva viral load
MeSH terms
Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Leukocytes, Mononuclear, Male, Prospective Studies, Recurrence, Virus Activation, Herpesvirus 6, Human, Herpesvirus 7, Human, Roseolovirus Infections, Reverse Transcriptase Polymerase Chain Reaction

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