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Cited by 35Vascular Malformations Diagnosis and TreatmentVascular Malformations and HemangiomasFetal and Pediatric Neurological Disorders

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Epidemiology, Diagnostics, and Management of Vein of Galen Malformation

Brevis Nuñez, Francisco, Dohna-Schwake, Christian·2021·Pediatric Neurology
DOI 10.1016/j.pediatrneurol.2021.02.007
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Abstract

Background Vein of Galen malformation (VGM) is a rare congenital intracerebral vascular malformation. The aim of this study was to gain reliable data about epidemiology; clinical manifestations; and pre-, peri- and postinterventional treatment strategies in Germany. Methods This prospective epidemiologic study was conducted by Erhebungseinheit für Seltene Pädiatrische Erkrankungen in Deutschland, a hospital-based German nationwide surveillance unit for rare pediatric diseases. Patients aged upto 18 years with a new diagnosis of VGM were prospectively included between January 1, 2014 and December 31, 2015. Results In the two-year study period, 30 individuals with newly diagnosed VGM were identified, resulting in an estimated annual incidence rate of VGM in Germany of at least 1: 58,100 live births. The main symptoms were age dependent. Neonates presented with mainly cardiac manifestations of high output failure; infants and older children mainly suffered from neurological complications. Of the patients with endovascular treatment 95% survived, but only 41% of these patients were discharged home without any complications. The Bicêtre Neonatal Evaluation Score was a good predictor for poor outcome but could have led to palliative care in some patients with good outcome. Conclusions The incidence of VGM in Germany is estimated to be 1:58,100 live births. The majority of patients were eligible for endovascular treatment. Nevertheless, due to side effects and long-term sequelae in…

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Research works printed but not linked: 1

  1. Werlein, 2014, Planning delivery in cases of congenital malformations from the neonatologist’s point of view, Z Geburtshilfe Neonatol, 218, 27

Cited by

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Metadata

Authors
Brevis Nuñez, F., & Dohna-Schwake, C.
ORCID
Dohna-Schwake, Christian
Venue
Pediatric Neurology
Publisher
Elsevier BV
Published
2021-06
Volume
119
Pages
50-55
ISSN
0887-8994 (ISSN-L)
DOI
10.1016/j.pediatrneurol.2021.02.007
OpenAlex
W3133772163
Cited by
35
References
38
Citations by year
2026: 8 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 4
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pediatric Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Vascular Malformations Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Vascular Malformations and Hemangiomas
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
vein of Galen malformation, incidence, epidemiology, endovascular treatment, neurological complications, high-output heart failure, neonatal outcome prediction, palliative care, pediatric rare diseases, Germany
MeSH terms
Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Vein of Galen Malformations, Endovascular Procedures

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CoChat. (2026). Citation check: Epidemiology, Diagnostics, and Management of Vein of Galen Malformation. https://app.cochat.ai/papers/10.1016/j.pediatrneurol.2021.02.007
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Brevis Nuñez, F., & Dohna-Schwake, C. (2021). Epidemiology, Diagnostics, and Management of Vein of Galen Malformation. Pediatric Neurology. https://doi.org/10.1016/j.pediatrneurol.2021.02.007

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