CoChat
Sign Up
Cited by 45Thyroid Disorders and TreatmentsMetabolism and Genetic DisordersThyroid and Parathyroid Surgery

Three-year follow-up of children with abnormal newborn screening results for congenital hypothyroidism

Open access
Kang, Min-Jae, Chung, Hye-Rim, Oh, Yeon-Joung, Shim, Young-Suk, Yang, Seung, Hwang, Il-Tae·2017·Pediatrics & Neonatology
DOI 10.1016/j.pedneo.2017.01.002
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: To analyze predictive factors suggesting transient congenital hypothyroidism (TCH) compared to permanent congenital hypothyroidism (PCH) or transient thyroid function test (TFT) abnormalities among children who had positive screening results at our centers over the past decade. METHODS: A retrospective chart review of 105 subjects who presented elevated TSH levels on a newborn screening test (NST) was done. TCH was defined when a trial-off therapy was successful, and PCH was defined when a trial failed or when the subject was kept on medication beyond 3 years of age. A transient TFT abnormality was defined when follow-up TFTs were normalized without levothyroxine (LT4) therapy. RESULTS: Congenital hypothyroidism (CH) was diagnosed in 75.2% (TCH 35.2% and PCH 40.0%) of all subjects; the others (24.8%) showed transient TFT abnormalities. Initial NST-TSH levels (optimal cutoff point, 31.0 μIU/mL), the LT4 dose at 2 years of age (4.1 μg/kg/day), and the maximal LT4 dose (50 μg/day) merged as significant predictive factors discriminating between TCH and PCH. The initial serum level of free T4 (1.06 ng/dL) and not TSH (27.2 μIU/mL) was the only discriminating factor between transient TFT abnormalities and TCH. CONCLUSION: Earlier re-evaluation might be possible when a patient's initial NST-TSH levels and maximal or 2-year LT4 doses are low, as both are important predictors of successful trial-off therapy in CH patients. When the initial serum level of free T4 is above the average value in neonates with mildly elevated TSH levels, TFTs may be more likely to normalize on their own.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.pedneo.2017.01.002

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The size of implants providing a therapeutic LT4 dose can be reduced to 5 to 14 times that of the current implants.

    “Considering that the obtained plasma concentration was >2000 times that required for healthy humans (274) and the weight of the average human body is >300 times the weight of rats, the size of implants providing a therapeutic LT4 dose can be reduced to 5 to 14 times that of the current implants.”

    From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [274]

  • The obtained plasma concentration was more than 2000 times that required for healthy humans.

    “Considering that the obtained plasma concentration was >2000 times that required for healthy humans (274) and the weight of the average human body is >300 times the weight of rats, the size of implants providing a therapeutic LT4 dose can be reduced to 5 to 14 times that of the current implants.”

    From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [274]

  • Factors associated with transient congenital hypothyroidism include male sex, low birthweight, neonatal morbidity requiring intensive care, nonwhite race/ethnicity, and less severe congenital hypothyroidism at diagnosis.

    “In a number of studies, factors have been identified that increase the likelihood of transient disease, such as sex (more often in boys) (132,133), low birthweight (134,135), neonatal morbidity requiring intensive care (135), race/ethnicity (more often in nonwhite patients) (14), and less severe CH at diagnosis (assessed by screening TSH, or diagnostic TSH or fT4) (8,132,133,136–141).”

    From Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology (2021) · cites this paper as [137]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 32 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Kang, M.-J., Chung, H.-R., Oh, Y.-J., Shim, Y.-S., Yang, S., & Hwang, I.-T.
Affiliations
  • Hallym University Sacred Heart Hospital (KR)
  • Seoul National University (KR)
  • Hallym University Kangnam Sacred Heart Hospital (KR)
  • Hallym University Dongtan Sacred Heart Hospital (KR)
  • Kangdong Sacred Heart Hospital (KR)
Corresponding author
Hwang, Il-Tae
ORCID
Venue
Pediatrics & Neonatology
Publisher
Elsevier BV
Published
2017-10
Volume
58
Issue
5
Pages
442-448
ISSN
1875-9572 (ISSN-L)
DOI
10.1016/j.pedneo.2017.01.002
OpenAlex
W2603843453
Cited by
45
References
32
Citations by year
2026: 2 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 11 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 2
FWCI
2.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Pediatrics & Neonatology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
congenital hypothyroidism, transient congenital hypothyroidism, permanent congenital hypothyroidism, newborn screening, thyroid-stimulating hormone, thyroid function tests, free thyroxine, predictive factors, follow-up
MeSH terms
Child, Preschool, Congenital Hypothyroidism, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Thyrotropin, Thyroxine, Neonatal Screening

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review