Heme as key regulator of major mammalian cellular functions: Molecular, cellular, and pharmacological aspects

Mitochondrial control of cell death

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Microsomal Heme Oxygenase

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Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. Resolution

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Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

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Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

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The heme synthesis and degradation pathways: role in oxidant sensitivity

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Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

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Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways

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Current states and future views in photodynamic therapy

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Physiology and Pathophysiology of Heme

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The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates

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Nonheme-iron histochemistry for light and electron microscopy: a historical, theoretical and technical review

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Heme Degradation and Vascular Injury

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One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans

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Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres

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Targeting the Redox Balance in Inflammatory Skin Conditions

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Trafficking of Heme and Porphyrins in Metazoa

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Neurons express hemoglobin α‐ and β‐chains in rat and human brains

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Erythropoiesis: Model systems, molecular regulators, and developmental programs

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Progesterone Receptor Membrane Component-1 (PGRMC1) Is the Mediator of Progesterone’s Antiapoptotic Action in Spontaneously Immortalized Granulosa Cells As Revealed by PGRMC1 Small Interfering Ribonucleic Acid Treatment and Functional Analysis of PGRMC1 Mutations

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Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

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Fungal–Metal Interactions: A Review of Toxicity and Homeostasis

Robinson, J. R., Isikhuemhen, O. S., & Anike, F. N. (2021) · Journal of Fungi · doi:10.3390/jof7030225 · Cited by 187

Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins

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Nuclear receptor Rev-erbα: up, down, and all around

Everett, L. J., & Lazar, M. A. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.06.011 · Cited by 159

The Role of Iron in Cancer Progression

Guo, Q., Li, L., Hou, S., Yuan, Z., Li, C., Zhang, W., Zheng, L., & Li, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.778492 · Cited by 150

From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

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GAPDH regulates cellular heme insertion into inducible nitric oxide synthase

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Schistosome Feeding and Regurgitation

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The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

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Interactions between metabolism and circadian clocks: reciprocal disturbances

Delezie, J., & Challet, É. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06246.x · Cited by 124

Protein-Metal Organic Framework Hybrid Composites with Intrinsic Peroxidase-like Activity as a Colorimetric Biosensing Platform

Yin, Y., Gao, C., Xiao, Q., Lin, G., Lin, Z., Cai, Z., & Yang, H. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b09893 · Cited by 116

Innate Nutritional Immunity

Núñez, G., Sakamoto, K., & Soares, M. P. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800325 · Cited by 115

Mechanism‐Guided Design and Synthesis of a Mitochondria‐Targeting Artemisinin Analogue with Enhanced Anticancer Activity

Zhang, C., Wang, J., Zhang, J., Lee, Y. M., Feng, G., Lim, T. K., Shen, H., Lin, Q., & Liu, B. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201607303 · Cited by 112

Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

Larsen, R., Gouveia, Z. L., Soares, M. P., & Gozzelino, R. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00077 · Cited by 115

Physiological and molecular analyses of black and yellow seeded Brassica napus regulated by 5-aminolivulinic acid under chromium stress

Gill, R. A., Ali, B., Islam, F., Farooq, M. A., Gill, M. B., Mwamba, T. M., & Zhou, W. (2015) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2015.06.001 · Cited by 108

Phyto-management of chromium contaminated soils through sunflower under exogenously applied 5-aminolevulinic acid

Farid, M., Ali, S., Rizwan, M., Ali, Q., Saeed, R., Nasir, T., Abbasi, G. H., Rehmani, M. I. A., Ata-Ul-Karim, S. T., Bukhari, S. A. H., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.01.017 · Cited by 107

5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction

Fujino, M., Nishio, Y., Ito, H., Tanaka, T., & Li, X. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.11.034 · Cited by 103

Heme and blood-feeding parasites: friends or foes?

Toh, S. Q., Glanfield, A., Gobert, G. N., & Jones, M. K. (2010) · Parasites & Vectors · doi:10.1186/1756-3305-3-108 · Cited by 102

The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

Serwetnyk, M. A., & Blagg, B. S. J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.11.015 · Cited by 98

ABCG2 Transports and Transfers Heme to Albumin through Its Large Extracellular Loop*

Mandon, E. D., Arnaud, O., Martinez, L., Huché, F., Pietro, A. D., & Falson, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.139170 · Cited by 103

Hemoglobin Expression in Nonerythroid Cells: Novel or Ubiquitous?

Saha, D., Patgaonkar, M. S., Shroff, A., Ayyar, K. K., Bashir, T., & Reddy, K. V. R. (2014) · International Journal of Inflammation · doi:10.1155/2014/803237 · Cited by 91

Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine

Kuten-Pella, O., Hornyák, I., Horvathy, D. B., Fodor, E. K., Nehrer, S., & Lacza, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810557 · Cited by 99

Kinetics and Specificity of Feline Leukemia Virus Subgroup C Receptor (FLVCR) Export Function and Its Dependence on Hemopexin

Yang, Z., Philips, J. D., Doty, R. T., Giraudi, P. J., Ostrow, J. D., Tiribelli, C., Smith, A., & Abkowitz, J. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.119131 · Cited by 89

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

Biancur, D. E., Kapner, K. S., Yamamoto, K., Banh, R. S., Neggers, J. E., Sohn, A. S. W., Wu, W., Manguso, R. T., Brown, A., Root, D. E., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.018 · Cited by 86

Nuclear Receptors Homo sapiens Rev-erbβ and Drosophila melanogaster E75 Are Thiolate-Ligated Heme Proteins Which Undergo Redox-Mediated Ligand Switching and Bind CO and NO

Marvin, K. A., Reinking, J. L., Lee, A. J., Pardee, K., Krause, H. M., & Burstyn, J. N. (2009) · Biochemistry · doi:10.1021/bi900697c · Cited by 81

Magnesium porphyrins with relevance to chlorophylls

Borah, K. D., & Bhuyan, J. (2017) · Dalton Transactions · doi:10.1039/c7dt00823f · Cited by 79

A π-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase

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Photodynamic Modulation of Wound Healing: A Review of Human and Animal Studies

Peplow, P. V., Chung, T., & Baxter, D. G. (2012) · Photomedicine and Laser Surgery · doi:10.1089/pho.2011.3142 · Cited by 76

Role of Redox Regulation and Lipid Rafts in Macrophages During Ox-LDL–Mediated Foam Cell Formation

Schmitz, G., & Grandl, M. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1663 · Cited by 76

Carbon monoxide: A vital signalling molecule and potent toxin in the myocardium

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Characterization of plasma labile heme in hemolytic conditions

Gouveia, Z., Carlos, A. R., Yuan, X., Aires‐da‐Silva, F., Stocker, R., Maghzal, G. J., Leal, S. S., Gomes, C. M., Todorovic, S., Iranzo, O., et al. (2017) · The FEBS Journal · doi:10.1111/febs.14192 · Cited by 70

5-Aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1

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Fabrication of Hemin-Doped Serum Albumin-Based Fibrous Scaffolds for Neural Tissue Engineering Applications

Hsu, C., Serio, A., Amdursky, N., Besnard, C., & Stevens, M. M. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18179 · Cited by 66

Promotion of 5-aminolevulinic acid treatment on leaf photosynthesis is related with increase of antioxidant enzyme activity in watermelon seedlings grown under shade condition

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Tuning the Binding Affinity of Heme-Responsive Biosensor for Precise and Dynamic Pathway Regulation

Zhang, J., Wang, Z., Su, T., Sun, H., Zhu, Y., Qi, Q., & Wang, Q. (2020) · iScience · doi:10.1016/j.isci.2020.101067 · Cited by 63

Nitric oxide blocks cellular heme insertion into a broad range of heme proteins

Waheed, S. M., Ghosh, A., Chakravarti, R., Biswas, A., Haque, M. M., Panda, K., & Stuehr, D. J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.038 · Cited by 62

Heme Signaling Impacts Global Gene Expression, Immunity and Dengue Virus Infectivity in Aedes aegypti

Bottino-Rojas, V., Talyuli, O. A. C., Jupatanakul, N., Sim, S., Dimopoulos, G., Venâncio, T. M., Bahia, A. C., Sorgine, M. H. F., de Oliveira, P. L., & Paiva‐Silva, G. O. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135985 · Cited by 61

Heme induced oxidative stress attenuates sirtuin1 and enhances adipogenesis in mesenchymal stem cells and mouse pre‐adipocytes

Puri, N., Sodhi, K., Haarstad, M., Kim, D.-H., Bohinc, S., Foglio, E., Favero, G., & Abraham, N. G. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24061 · Cited by 61

Overview of Cancer Metabolism and Signaling Transduction

Chae, H., & Hong, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010012 · Cited by 66

Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury

Sawicki, K. T., Shang, M., Wu, R., Chang, H., Khechaduri, A., Sato, T., Kamide, C., Liu, T., Prasad, S. V. N., & Ardehali, H. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002272 · Cited by 59

Autophagy: A necessary event during erythropoiesis

Grosso, R. A., Fader, C. M., & Colombo, M. I. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.04.001 · Cited by 63

ApoHRP-based assay to measure intracellular regulatory heme

Atamna, H., Brahmbhatt, M., Atamna, W., Shanower, G., & Dhahbi, J. M. (2014) · Metallomics · doi:10.1039/c4mt00246f · Cited by 56

Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders

Ryter, S. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115509 · Cited by 55

5-Aminolevulinic acid promotes anthocyanin accumulation in Fuji apples

Xie, L., Wang, Z. H., Cheng, X., Gao, J., Zhang, Z. P., & Wang, L. J. (2012) · Plant Growth Regulation · doi:10.1007/s10725-012-9772-5 · Cited by 55

N-acetylcysteine ameliorates acute kidney injury but not glomerular hemorrhage in an animal model of warfarin-related nephropathy

Ware, K. M., Qamri, Z., Özcan, A., Satoskar, A. A., Nadasdy, G. M., Rovin, B. H., Hebert, L. A., Nádasdy, T., & Brodsky, S. V. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00689.2012 · Cited by 55

Heme impairs the ball-and-chain inactivation of potassium channels

Sahoo, N., Goradia, N., Ohlenschläger, O., Schönherr, R., Friedrich, M., Plass, W., Kappl, R., Hoshi, T., & Heinemann, S. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313247110 · Cited by 53

Mechanism of Hypochlorous Acid-Mediated Heme Destruction and Free Iron Release

Maitra, D., Byun, J., Andreana, P. R., Abdulhamid, I., Saed, G. M., Diamond, M. P., Pennathur, S., & Abu-Soud, H. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.040 · Cited by 51

Circadian Redox and Metabolic Oscillations in Mammalian Systems

O'Neill, J. S., & Feeney, K. A. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5582 · Cited by 51

Oxidative stress and antioxidant therapeutic mechanisms

Liu, H. F., Jiao, Y., Wang, P., Chen, Y., Xu, M., Zhang, X., Zheng, X., & Yang, Z. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108962 · Cited by 61

Critical Role of ABCG2 in ALA-Photodynamic Diagnosis and Therapy of Human Brain Tumor

Ishikawa, T., Kajimoto, Y., Inoue, Y., Ikegami, Y., & Kuroiwa, T. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2014.11.008 · Cited by 50

Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis

Ishikawa, T., Nakagawa, H., Hagiya, Y., Nonoguchi, N., Miyatake, S., & Kuroiwa, T. (2010) · Advances in Pharmacological Sciences · doi:10.1155/2010/587306 · Cited by 51

Anticoagulants and acute kidney injury: clinical and pathology considerations

Brodsky, S. V. (2014) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2014.11.001 · Cited by 48

Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure

Collino, M., Pini, A., Mugelli, N., Mastroianni, R., Bani, D., Fantozzi, R., Papucci, L., Fazi, M., & Masini, E. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.011528 · Cited by 48

Synthesis, delivery and regulation of eukaryotic heme and Fe–S cluster cofactors

Barupala, D., Dzul, S. P., Riggs-Gelasco, P. J., & Stemmler, T. L. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.01.010 · Cited by 51

Heme controls the regulation of protein tyrosine kinases Jak2 and Src

Xiao, Y., Balamurugan, P., Arvey, A. J., Leslie, C. S., & Li, Z. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.101 · Cited by 44

Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity

Yanatori, I., Yasui, Y., Miura, K., & Kishi, F. (2012) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2012.03.004 · Cited by 43

Responses of the European flounderPlatichthys flesusto the chemical stress in estuaries: load of contaminants, gene expression, cellular impact and growth rate

Evrard, E., Devaux, A., Bony, S., Burgeot, T., Riso, R. D., Budzinski, H., Du, M. L., Quiniou, L., & Laroche, J. (2009) · Biomarkers · doi:10.3109/13547500903315598 · Cited by 42

Multilevel targeting of hematopoietic stem cell self-renewal, differentiation and apoptosis for leukemia therapy

Tsiftsoglou, A. S., Bonovolias, I. D., & Tsiftsoglou, S. A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.03.001 · Cited by 43

Label-Free Imaging of Heme Dynamics in Living Organisms by Transient Absorption Microscopy

Chen, A. J., Yuan, X., Li, J., Dong, P., Hamza, I., & Cheng, J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b05046 · Cited by 41

Oral administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in peripheral blood mononuclear cells of healthy human subjects in combination with ferrous iron

Ito, H., Nishio, Y., Hara, T., Sugihara, H., Tanaka, T., & Li, X. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.05.009 · Cited by 41

5-Aminolevulinic acid combined with sodium ferrous citrate ameliorates H 2 O 2 -induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathway

Zhao, M., Guo, H., Chen, J., Fujino, M., Ito, H., Takahashi, K., Abe, F., Nakajima, M., Tanaka, T., Wang, J., et al. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00369.2014 · Cited by 40

Plasminogen Activator Inhibitor 1 RNA-Binding Protein Interacts with Progesterone Receptor Membrane Component 1 to Regulate Progesterone's Ability to Maintain the Viability of Spontaneously Immortalized Granulosa Cells and Rat Granulosa Cells1

Peluso, J. J., Yuan, A. S., Liu, X., & Lodde, V. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.103036 · Cited by 43

Hemin, an iron‐binding porphyrin, inhibits HIF‐1α induction through its binding with heat shock protein 90

Lee, J. M., Lee, W. H., Kay, H. Y., Kim, E., Moon, A., & Kim, S. G. (2011) · International Journal of Cancer · doi:10.1002/ijc.26075 · Cited by 40

The antidepressant drug Carbamazepine induces differential transcriptome expression in the brain of Atlantic salmon, Salmo salar

Hampel, M., Bron, J. E., Taggart, J. B., & Leaver, M. J. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.12.018 · Cited by 40

Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress – a brief review

Sil, R., & Chakraborti, A. S. (2025) · Frontiers in Chemistry · doi:10.3389/fchem.2025.1543455 · Cited by 42

Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches

Sumi, M. P., & Ghosh, A. (2022) · Cells · doi:10.3390/cells11060976 · Cited by 42

Lipid Rafts and Redox Regulation of Cellular Signaling in Cholesterol Induced Atherosclerosis

Catalgol, B., & Özer, N. K. (2010) · Current Cardiology Reviews · doi:10.2174/157340310793566181 · Cited by 37

Single-cell RT-LAMP mRNA detection by integrated droplet sorting and merging

Chung, M. T., Kurabayashi, K., & Cai, D. (2019) · Lab on a Chip · doi:10.1039/c9lc00161a · Cited by 38

The Role of Tetrapyrrole- and GUN1-Dependent Signaling on Chloroplast Biogenesis

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Modulation by heme and zinc protoporphyrin of colonic heme oxygenase-1 and experimental inflammatory bowel disease in the rat

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