Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, pathophysiology, and treatment

Diagnostic and Statistical Manual of Mental Disorders

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Biological Mechanisms and Treatment of Obsessive–Compulsive Disorder

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Ketamine and Esketamine in Obsessive–Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence

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Cortical Neurodynamics, Schizophrenia, Depression, and Obsessive-Compulsive Disorder

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The Role of Glutamine and Glutamic Acid in the Pituitary Gland Involvement in Thyroid-Stimulating Hormone Release

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Metabolic and toxicological considerations for obsessive–compulsive disorder drug therapy

Sayyah, M., Majzoob, S., & Sayyah, M. (2013) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.783011 · Cited by 2

Neue Entwicklungen bei der psychotherapeutischen und pharmakologischen Behandlung der Zwangsstörung im Kindes- und Jugendalter

Vloet, T. D., Herpertz‐Dahlmann, B., & Simons, M. (2016) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000445 · Cited by 2

Passionate Love Addiction: An Evolutionary Survival Mechanism That Can Go Terribly Wrong

Bolshakova, M., Fisher, H. E., Aubin, H., & Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.026 · Cited by 2

Philosophical Issues in the Addictions

Glackin, S. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.007 · Cited by 2

Prevention and Treatment

(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.020 · Cited by 2

Pathophysiology of Obsessive-Compulsive Disorder: Insights from Normal Function and Neurotoxic Effects of Drugs, Infection, and Brain Injury

Szechtman, H., Shivji, S., & Woody, E. Z. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_118 · Cited by 3

Factors related to the severity of obsessive–compulsive symptoms and their impact on suicide risk in epileptic patients

Guo, X., Lin, W., Zhong, R., Han, Y., Yu, J., Yan, K., Zhang, X., & Liang, J. (2023) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2023.109362 · Cited by 2

Neurobiology of Tic Disorders and Obsessive–Compulsive Disorder

Pittenger, C. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197640654.003.0065 · Cited by 1

Cognitive-Behavioral Therapy of Obsessive-Compulsive Disorder in Children and Adolescents

Çimen, İ. D. (2018) · InTech eBooks · doi:10.5772/intechopen.70612 · Cited by 2

Short or moderate-time exposure to the inhalational anesthetics isoflurane and sevoflurane does not alter the marble-burying behavior in mice

Gaigher, T., Tosta, C. L., Herbst, L. S., & Beijamini, V. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135018 · Cited by 2

Relationship between Dopamine and Serotonin on the Effect of Ginkgo biloba Extract in the Treatment of Obsessive Compulsive Disorder in Rodents

Chimakurthy, J., Murthy, T. E. G. K., & Diwan, P. V. (2019) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.527 · Cited by 1

Dynamic Tracking to Identify Topics and Thematic Evolution of Obsessive-compulsive disorder as an Emerging Topic

Bakhshinejad, B., Khazaneha, M., Mehrabani, M., Sabahi, A., Sadatmoosavi, A., Tajedini, O., Esmaeili, O., & Mehrbani, M. (2024) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2024.00047 · Cited by 1

Role of Glutamatergic Modulators in the Treatment of Obsessive Compulsive and Related Disorders

Çelik, F. G. H., & Hocaoğlu, Ç. (2024) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.1279927 · Cited by 2

Neuroglia in Tourette syndrome and obsessive-compulsive disorder

Frick, L. R. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00005-3 · Cited by 1

Obsessive-compulsive disorder and temporal lobe porencephaly: a case report

Deng, G., Cao, Y., & Qiu, C. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06774-8 · Cited by 1

L-type voltage-dependent calcium channels in the ventromedial orbitofrontal and prefrontal cortices mediate the inhibitory effects of (S)-ketamine but not (R)-ketamine on marble burying in male mice

Deyama, S., Mishiro, K., Kunishima, M., & Kaneda, K. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178301 · Cited by 1

Prefrontal dysfunction and neurotransmitter imbalances underlying cognitive fusion in first-episode drug-naïve obsessive-compulsive disorder

Suo, X., Zhang, Y., Li, X., Xu, Z., Zeng, L., Lei, L., Zhang, M., Luo, Z., Xia, L., Zeng, X., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115962 · Cited by 1

A transgenic mouse line carrying the P654L (rs139336954) variant in the brain morphogenic protein Plxna3 reveals signs of obsessive-compulsive personality disorder

Karagyaur, M. N., Averina, O. A., Дмитриевич, Б. К., Станиславович, Д. С., Priymak, A. V., Permyakov, O. A., Grigorieva, O., Illarionova, M. E., Shkarina, L. N., Primak, A. L., et al. (2025) · Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery) · doi:10.33920/med-01-2511-08 · Cited by 1

Reconsidering the glutamate hypothesis of obsessive-compulsive disorder: A systematic review of proton magnetic resonance spectroscopy studies in unmedicated participants

Restifo-Bernstein, G., Guo, J., Kegeles, L. S., Shungu, D. C., & Simpson, H. B. (2026) · Journal of Mood and Anxiety Disorders · doi:10.1016/j.xjmad.2026.100168 · Cited by 1

Repeated intranasal esketamine augmentation in treatment-resistant obsessive-compulsive disorder with comorbid major depressive disorder: a prospective case series

López-Rodríguez, S., Segalàs, C., Real, E., Urretavizcaya, M., Bertolín, S., Menchón, J. M., & Alonso, M. D. P. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08119-5 · Cited by 1

Efficacy of Antipsychotic Augmentation Therapy in Treatment-Resistant Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

Shahtou, A., Omara, H. R., Qari, S. A., Alqahtani, R. S., Alnasyan, Z. S., Alotaibi, A. E., Ali, A. A., Alabdulrahim, J. M., Naser, S. A., Asad, N., et al. (2026) · Cureus · doi:10.7759/cureus.108358 · Cited by 1

Increased Posterior Cingulate Glutamate and Choline Measured by Magnetic Resonance Spectroscopy in Hypothyroidism

Gong, Y., Bai, Z.-L., Liu, X., Zhang, Q., Wang, S., Liu, F., & Dai, X.-Q. (2013) · Applied Magnetic Resonance · doi:10.1007/s00723-013-0500-8 · Cited by 1

N-Acetylcysteine for the Treatment of Obsessive-Compulsive Disorder

Fritzen, F., & Bloch, M. H. (2014) · Current Psychiatry Reviews · doi:10.2174/1573400510666140807005327 · Cited by 1

Excoriation: What Counselors Need to Know About Skin Picking Disorder

Jagger, G. E., & Sterner, W. R. (2016) · Journal of Mental Health Counseling · doi:10.17744/mehc.38.4.01 · Cited by 1

Prevention and Treatment of Work Addiction

Quiñones, C., & Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.028 · Cited by 2

Concepts of Addiction

Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.003 · Cited by 1

Zwangsstörungen

Voderholzer, U. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_70 · Cited by 1

Chapter 14. Obsessive-Compulsive and Related Disorders

Dougherty, D. D., Wilhelm, S., & Jenike, M. A. (2019) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615372980.lr14 · Cited by 1

Structural and resting-state connection abnormalities of habenula in obsessive-compulsive disorder

Liu, Q., Wang, X., Cao, Y., Gao, F., Xia, J., Du, H., Liao, H., Tan, C., Fan, J., & Zhu, X. (2024) · Psychological Medicine · doi:10.1017/s003329172400045x · Cited by 1

The Role of Immune-Inflammatory Factors in the Pathophysiology of Obsessive–Compulsive Disorder

Xu, X., Li, Z., Wan, S., & Xiao, C. (2024) · Integrated science · doi:10.1007/978-3-031-72079-6_10 · Cited by 1

Pharmacological Treatments for Obsessive-Compulsive and Related Disorders: A Transdiagnostic Perspective

Sachdev, R. A., Ruparelia, R., Reid, J. E., Mpavenda, D., Cinosi, E., & Fineberg, N. A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108164313.016 · Cited by 1

Adolescent Drug Misuse Prevention: Challenges in School-Based Programming

Scheier, L. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.021 · Cited by 1

Measurement, Prevention, and Treatment of Exercise Addiction

Hausenblas, H. A., Mann, D. T. Y., & Downs, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.036 · Cited by 2

Neurochemistry of Childhood Anxiety Disorders

Havel, L. K., Mehta, P., Gautam, A., Danielyan, E., & Saxena, K. (2022) · Springer eBooks · doi:10.1007/978-3-031-14080-8_5 · Cited by 1

Successful Early Lamotrigine and Aripiprazole Augmentation of Clomipramine in Severe Obsessive-compulsive Disorder

Seo, E. H., Kim, S.-G., Lee, J.-H., & Yoon, H. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.22.1044 · Cited by 1

Potencialização de inibidores da recaptura de serotonina com N-acetilcisteína no tratamento do transtorno obsessivo-compulsivo resistente: estudo duplo-cego e controlado

Costa, D. L. D. C. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2016.tde-05122016-164417 · Cited by 1

Biological Models and Treatments for OCD in Adults

Stewart, S. E., & Loh, A. S. (2017) · Wiley eBooks · doi:10.1002/9781118890233.ch14 · Cited by 1

Low-level Chlorpyrifos Exposure Affects Synaptic Plasticity in Hippocampal NeuronsPreprint

Zhou, W., Zhang, C., Wang, P., Deng, Y., Dai, H., Qiong, X., Tian, J., Zhao, M., Wu, G., & Zhao, L. (2021) · Research Square · doi:10.21203/rs.3.rs-377989/v1 · Cited by 1

Evaluation of Potential Biomarker Mirnas and the Levels of Serotonin and Dopamine in Patients with Obsessive-Compulsive DisorderPreprint

Korkmaz, N. D., Elibol, B., Durmus, Z. B., Ozdemir, A., Akbaş, F., Gülöksüz, S., & Şahbaz, Ç. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5135082 · Cited by 1

The Sapap3-knockout mouse model manifests a spectrum of repetitive behavioursPreprint

Lamothe, H., Schreiweis, C., Mallet, L., & Burguière, E. (2021) · HAL · doi:10.1101/2020.01.22.915215

Cellular Mechanism of Obsessive-Compulsive Disorder

Tee, L. Y. (2015) · DukeSpace (Duke University)

Obsessive control and challenging tests. Experimental studies on neurobiological mechanisms in the pathogenesis and treatment of obsessive-compulsive disorder

de Leeuw, A. S. (2013) · Utrecht University Repository (Utrecht University)

Variações raras no genoma de pacientes com transtorno obsessivo-compulsivo

Cappi, C. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2013.tde-09092013-160344

Add-on Memantine Treatment for a Complicated Case of Juvenile Bipolar Mood Disorder with Co-morbid Obsessive-compulsive Disorder

Naguy, A. (2015) · Journal of psychiatry · doi:10.4172/2378-5756.1000291

Social dysfunction and mental retardation

Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.010

A theoretical study of the role of astrocyte activity in neuronal hyperexcitability using a new neuro-glial mass modelPreprint

Garnier, A., Vidal, A. C., & Benali, H. (2015) · arXiv (Cornell University) · doi:10.48550/arxiv.1510.01313

Trastorno obsesivo compulsivo con tics motores y verbales, trastorno de acumulación y síndrome del acento extranjero sin afasia: comunicación de un caso y revisión bibliográfica. Obsessive compulsive disorder with motor and vocal tics, hoarding behaviour and foreign accent syndrome without aphasia: a case report and literature review.

Perlado, F. L., Mentxaka-Solozabal, O., Diaz-Guardamino, E. M., Rivas, M. C., Erazo-Presser, P., & Miranda-Artieda, Z. M. (2013)

Oral Pharmacological Augmentation Strategies for Adults with Obsessive-Compulsive Disorder: Alternatives to Antipsychotics and Clomipramine

Scarff, J. R. (2014) · The Internet Journal of Psychiatry

Obsessive–compulsive disorder and Gilles de la Tourette syndrome

Woehrle, N. S., & Dulawa, S. C. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.016

Emerging Data for Ketamine in Obsessive-Compulsive, Stress-Related, and Substance Use Disorders

Rodríguez, C. I., & Dakwar, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-42925-0_9

Integrative Therapie der Zwangsstörungen

Voderholzer, U. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_70-1

The Molecular Genetics of Obsessive-Compulsive and Related Disorders

Kohlrausch, F. B. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108164313.005 · Cited by 1

Investigation and Clinical Importance of Obsessive and Compulsive Signs Among Patients with Restless Legs Syndrome

Şengül, Y., Yılmaz, O., Sengul, H., Yıldız, F. B. P., & Öztürk, A. (2019) · Bezmialem Science · doi:10.14235/bas.galenos.2018.2607

Foreword

Compton, W. M., & Blanco, C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.001

Novel Psychoactive Substances: A New Challenge for Prevention and Treatment

Kapitány‐Fövény, M., Corazza, O., Marrinan, S., & Demetrovics, Z. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.032

Human Laboratory Paradigms in Addictions Research

Morris, V. L., Arshad, F., Balodis, I. M., Reed, D. D., MacKillop, J. M., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.010

Anhedonia in Addictive Behaviors

Dyer, W. G., Leventhal, A. M., Goldenson, N. I., & Bello, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.039

American Legal Issues in Addiction Treatment and Research

Willick, D. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.041

The Physical and Social Environments as Determinants of Health: Implications for Substance and Behavioral Addictions

Strack, R. W., Orsini, M. M., Ewald, D. R., & Scheier, L. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.019

Evaluación in-vitro de péptidos sintéticos diseñados a partir de la Conantoquina G (Con-G) con interacción sobre la subunidad GluN2B del receptor de Glutamato tipo N-metil-D-aspartato (NMDAr) y su posible efecto sobre las vías de señalización involucradas en procesos de excitotoxicidad por calcio

Alejo, V., & Alejo, N. E. V. (2020)

Update on Neurodegenerative Diseases and Glutamate: A PMHNP Single Case Study Report of a Diagnostically Complex Adult Patient, Interventions, and Unexpected Outcomes

Kroll, S. C., Bennett, C. F., & Klinefelter, T. W. (2021) · Journal of the American Psychiatric Nurses Association · doi:10.1177/10783903211030343

Connecting the dots: Structural and functional connections in healthy and diseased brain

Straathof, M. (2021) · Utrecht University Repository (Utrecht University) · doi:10.33540/877

Clinical and Research Methods in the Addictions

Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.008

Levels of Analysis and Etiology

(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.014

Ongoing and Future Research Directions

(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.030

Preface

Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.002

Impaired Physicians

Srivastava, A. B., & Gold, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.033

Neurocognitive and Dysfunctional Belief Candidate Endophenotypes of Obsessive-Compulsive and Related Disorders

Taillefer, S. E. (2021) · doi:10.32920/ryerson.14646846.v1

Index

Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.042

Faculty Opinions recommendation of Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis.

Shavitt, R. G. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727864723.793580414

The individual vulnerability to develop compulsive adjunctive behavior is associated with the recruitment of activity-regulated cytoskeleton-associated protein (Arc) within the Locus CoeruleusPreprint

Velázquez-Sánchez, C., Mureşan, L., & Belin, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.13.507749

Modelling Transition From Normal To Epileptic Eeg Signals: A Neuron-Astrocyte Mass Action Approach

Agboola, H., Solebo, C., Aribike, D. S., Lesi, F., & Susu, A. A. (2018) · Proceedings of the Nigerian Academy of Science · doi:10.57046/sfah7243

T-cell deficiency induces deficits in social behavior and dyslipidemia in mice

Asami, S., Tsutsui, Y., Yamamoto, S., & Miyajima, M. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.01.059

A GENÉTICA E O TRANSTORNO OBSESSIVO COMPULSIVO: ESTUDOS CLÁSSICOS E MOLECULARES

Kohlrausch, F. B. (2023) · Editora Científica Digital eBooks · doi:10.37885/230312474

Ciências Biológicas e da Saúde: integrando saberes em diferentes contextos - Volume 3

Barbosa Neto, O., Praxedes, M. F. D. S., Silva, P. F. D., & Carvalho Junior, F. F. D. (2023) · Editora Científica Digital eBooks · doi:10.37885/978-65-5360-335-6

A Review on Obsessive Compulsive Disorder: Neurotransmitters, Biomarkers and Pharmacotherapy

Singh, M., Majhi, S., & Kataria, R. (2023) · Current Indian Science · doi:10.2174/012210299x256025231010053232 · Cited by 2

Obsessive-Compulsive Disorder Comorbid with Bipolar Disorder

Miyazaki, T., & Ishihara, T. (2023) · Anxiety Disorder Research · doi:10.14389/jsad.15.1_31

Chapter 52. Treatment of Obsessive-Compulsive Disorder

Kayser, R. R., & Simpson, H. B. (2024) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375523.as52 · Cited by 1

Immuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder PatientsPreprint

Blacksell, I. A., Vismara, M. E. M., Lim, C. M., Dell’Osso, B. M., Pallanti, S., Hollander, E., Vendruscolo, M., D’Addario, C., Cooper, D., & D’Acquisto, F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.16.628685

Obsessive-Compulsive Disorder and 1H-MRS: A Focus on Brain Glutamate and Gamma-Aminobutyric Acid

Batistuzzo, M. C., Hoexter, M. Q., Otaduy, M. C. G., & de Joode, N. T. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_75-1

Grundlagen der Diagnostik und Therapie

(2024) · Elsevier eBooks · doi:10.1016/b978-3-437-22487-4.16001-0

Hyperoside ameliorates neuroinflammation associated depression via induced aldehyde dehydrogenase 2 activation: in silico and in vitro insights

Song, A., & Hao, L. (2025) · New Journal of Chemistry · doi:10.1039/d4nj05416d

Control of striatal activity by neuronal glutamate transporters

De, M. (2018) · doi:10.54014/f9cc-bnxw

MrgD Receptor Modulates Neurotransmission in the Nigrostriatal PathwayPreprint

Rodrigues‐Ribeiro, L., Oliveira, B. D. S., Santos, K. S. B., Machado, C. A., Nawrocki, A., Santos, M. P., de Miranda, A. S., Guatimosim, C., Larsen, M. R., Santos, R. A. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.10.664011

Obsessive-Compulsive Disorder and1H-MRS: A Focus on Brain Glutamate and Gamma-Aminobutyric Acid

Batistuzzo, M. C., Hoexter, M. Q., Otaduy, M. C. G., & de Joode, N. T. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_75

Innovative treatment approaches for paediatric obsessive-compulsive disorder

Marazziti, D., Gurrieri, R., Gambini, M., Russomanno, G., Palagini, L., & Mucci, F. (2025) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2025.2591073

Chapter 10. Behavioral Addictions

Farhat, L. C., & Potenza, M. N. (2025) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550862.lg10

Role of diabetes and altered metabolic homeostasis in age-related dementia

Biswas, T., Ahmed, M. A., Bhowmick, S., & Mondal, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33355-2.00028-1

Additional file 1 of Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis

Hadi, F., Kashefinejad, S., Kamalzadeh, L., Hoobehfekr, S., & Shalbafan, M. (2021) · Figshare · doi:10.6084/m9.figshare.16935936

Additional file 1 of Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation

de Oliveira, K. C., Camilo, C., Gastaldi, V. D., Sant’Anna Feltrin, A., Lisbôa, B. C. G., de Jesus Rodrigues de Paula, V., Moretto, A. C., Lafer, B., Hoexter, M. Q., Miguel, E. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16909878

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