The DOI matches its Crossref record; 199 of the 202 references it cites were found in a registry or an index.
Integrins as receptor targets for neurological disorders
Open accessAbstract
This review focuses on the neurobiology of integrins, pathophysiological roles of integrins in neuroplasticity and nervous system disorders, and therapeutic implications of integrins as potential drug targets and possible delivery pathways. Neuroplasticity is a central phenomenon in many neurological conditions such as seizures, trauma, and traumatic brain injury. During the course of many brain diseases, in addition to intracellular compartment changes, alterations in non-cell compartments such as extracellular matrix (ECM) are recognized as an essential process in forming and reorganizing neural connections. Integrins are heterodimeric transmembrane receptors that mediate cell-ECM and cell-cell adhesion events. Although the mechanisms of neuroplasticity remain unclear, it has been suggested that integrins undergo plasticity including clustering through interactions with ECM proteins, modulating ion channels, intracellular Ca(2+) and protein kinase signaling, and reorganization of cytoskeletal filaments. As cell surface receptors, integrins are central to the pathophysiology of many brain diseases, such as epilepsy, and are potential targets for the development of new drugs for neurological disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among the top enriched up-regulated pathways in the aggressive Lidia group, the integrin and Alzheimer disease-presenilin signaling pathways are well-known gene routes in the development of abnormal aggressive behaviors [48] (Table 3).”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [48]
In the citing paper
“Increased expression of integrins contributes to imbalanced synaptic function in specific pathological conditions, such as Alzheimer disease and schizophrenia, both often accompanied by episodic aggression and violence [48].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Integrins: Versatility, modulation, and signaling in cell adhesion
Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,857 · cited 2×
“…Ca2+ and K+ ion channels, intracellular Ca2+ concentrations, cellular contractile properties, protein kinase activity, and growth factor receptors (Hynes, 1992; Yip & Marsh, 1997; Porter & Hogg, 1998; Wu et al., 1998; Barouch et al., 2000; Chan et al., 2001; Danen & Yamada, 2001; Davis et al.,…”
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606 · cited 1×
“Co-stimulation of integrins and epidermal growth factor (EGF) receptors activates Pyk2 and FAK to promote outgrowth of neurite via paxillin induced cytoskeletal changes (Ivankovic-Dikic et al., 2000).”
Mechanotransduction Across the Cell Surface and Through the Cytoskeleton
Wang, N., Butler, J. P., & Ingber, D. E. (1993) · Science · doi:10.1126/science.7684161 · Cited by 3,007
Integrins and Signal Transduction Pathways: the Road Taken
Clark, E. A., & Brugge, J. S. (1995) · Science · doi:10.1126/science.7716514 · Cited by 2,911 · cited 5×
“This signal transduction has been also shown to result in protein phosphorylation, increased intracellular calcium concentration, activation of glutamate receptor, gene transcription, and the release of neurotransmitters (Clark & Brugge, 1995).”
InfluentialThe blood–brain barrier: an overview
Ballabh, P., Braun, A., & Nedergaard, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.016 · Cited by 2,276 · cited 12×
“The third strategy is to bypass the BBB and deliver the drugs to CNS through an intraventricular/intrathecal route, the olfactory pathway, an interstitial/intracranial drug delivery via releasing drugs from biological tissues, nanoparticles and pumps.”
InfluentialTransmembrane crosstalk between the extracellular matrix and the cytoskeleton
Geiger, B., Bershadsky, A. D., Pankov, R. G., & Yamada, K. M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35099066 · Cited by 2,213
Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J. D., Dalton, S. L., Wu, J., Pittet, J.-F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80545-0 · Cited by 2,076 · cited 1×
“Mice lackingαvβ6 integrin develop exaggerated inflammation (Munger et al., 1999).”
The Sequence of the Human Genome
Venter, J. C., Smith, H. O., & Adams, M. D. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.237016 · Cited by 1,665
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · cited 1×
“Sniffing (intranasal) neuropeptides of melanocortin, vasopressin and insulin achieved direct access to the cerebrospinal fluid within 30 min, bypassing the bloodstream in human trials (Born et al., 2002).”
Flagged first, then by citations
3 of the 202 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Wu, 1998, 2, 27
- Wu, 2010, Fibronectin-induced mechanotransduction mediated by alpha (5) beta (1) integrin requires calcium and vinculin in mouse cardiomyocytes, Circulation, 122, A19792
- Wu, 2008, Mechanical properties of the interaction between fibronectin and integrins on diabetic cardiomyocytes, Circulation, 118, S318
Cited by
Sorted by citations
Items 101–175 of 175
Chen, N., Zhang, J., Han, C., & Meng, F. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001644 · Cited by 9
“It is reported that seizures could up-regulate the expression of multiple ECM and integrin molecules([29-31]) including Col18a1, Lama2, metalloproteinases (MMPs), and Itgb1.”
BackgroundYilmaz-Bayraktar, S., Schwieger, J., Scheper, V., Lenarz, T., Böer, U., Kreienmeyer, M., Mariela Torrente, A., & Doll, T. (2019) · The International Journal of Artificial Organs · doi:10.1177/0391398819868481 · Cited by 9
Regional variances depict a unique glial-specific inflammatory response following closed-head injury
White, M. R., & VandeVord, P. J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1076851 · Cited by 8
“The unique morphology they observed was associated with an upregulation in β1-integrin (CD29), a protein involved in the ramification of microglia, most often upregulated in neurodegenerative diseases (Wu and Reddy, 2012; Hinwood et al., 2013).”
BackgroundWang, Y., Schneider, S. W., & Gorzelanny, C. (2023) · Cancers · doi:10.3390/cancers15113025 · Cited by 9
Extracellular vesicles as the drug delivery vehicle for gene-based therapy
Aquino, A. D., Rubinstein, A., Кудрявцев, И. В., Yakovlev, A. A., & Головкин, А. С. (2025) · Applied Physics Reviews · doi:10.1063/5.0255519 · Cited by 9
Mostafa, D. G., Satti, H. H., Khaleel, E. F., & Badi, R. M. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00744-2 · Cited by 8
Suciu, F., Mihai, D. P., Ungurianu, A., Andrei, C., Pușcașu, C., Chițescu, C. L., Ancuceanu, R., Gîrd, C. E., Ștefănescu, E., Blebea, N. M., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136426 · Cited by 7
“The main constituents of AAE, such as ferulic acid, are recognized for their neuroprotective and anticonvulsant properties, which are mediated by anti-inflammatory pathways and the modulation of neuronal excitability [20,21,41,42].”
InfluentialThe potential and therapeutic advances of the integrin family in neurological disorders
Zhang, X., Gao, L., Wang, Y., Meng, Q., Bai, M., Xu, D., Wang, Y., Wang, J., Bi, H., & Ding, Y. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00020 · Cited by 7
Guidelines To Predict Binding Poses of Antibody–Integrin Complexes
Chaves, B., Sartori, G., VASCONCELOS, D. B., Savino, W., Caffarena, E. R., Cotta-de-Almeida, V., & da Silva, J. H. M. (2020) · ACS Omega · doi:10.1021/acsomega.0c00226 · Cited by 8
Gil‐Jaramillo, N., Aristizábal-Pachón, A. F., Aleman, M. A. L., Gómez, V. G., Hurtado, H. D. E., Pinto, L. C. G., Camacho, J. S. J., Rojas-Cruz, A. F., González‐Giraldo, Y., Pinzón, A. M., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1195840 · Cited by 7
“Noteworthy, on the other hand, integrins, as ECM receptors, have shown a relation with neuroplasticity, modulating ion channels, and reorganization of cytoskeletal filaments (Wu and Reddy, 2012).”
BackgroundRecombinant Integrin β1 Signal Peptide Blocks Gliosis Induced by Aβ Oligomers
Ortiz-Sanz, C., Llavero, F., Zuazo-Ibarra, J., Balantzategi, U., Quintela‐López, T., Wyssenbach, A., Capetillo‐Zarate, E., Matute, C., Alberdi, E. M., & Zugaza, J. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105747 · Cited by 7
“However, integrins also have functional relationships with other membrane receptors such as ion channels including NMDA receptors and growth factor receptors [32].”
BackgroundGiunti, S., Blanco, M. G., Rosa, M. J. D., & Rayes, D. (2024) · eLife · doi:10.7554/elife.94520.3 · Cited by 6
Qamar, Z., Khan, S. A., Kumari, P., Khan, M., Krishna, P. V. V. S., Dang, S., Baboota, S., Ali, A., & Ali, J. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2578384 · Cited by 6
“The unique cellular makeup of GBM tissues positions integrins as crucial targets for precision drug delivery [163,167,168].”
Physicochemical Principles of Adhesion Mechanisms in the Brain
Stachowicz, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065070 · Cited by 6
“The effect of integrins on LTP was demonstrated by a knockout of the gene encoding α-integrin in Drosophila, resulting in impaired short-term olfactory learning [22,41].”
BackgroundInfluentialAlzheimer’s disease protein relevance analysis using human and mouse model proteomics data
Shi, C., Gottschalk, W. K., Colton, C. A., Mukherjee, S., & Lutz, M. W. (2023) · Frontiers in Systems Biology · doi:10.3389/fsysb.2023.1085577 · Cited by 6
Targetting αvβ3 and α5β1 integrins with Ecballium elaterium (L.) A. Rich. seed oil
Touihri-Barakati, I., Kallech-Ziri, O., Boulila, A., Khwaldia, K., Marrakchi, N., Hanchi, B., Hosni, K., & Luis, J. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.035 · Cited by 6
Corrêa, T., Venâncio, A. C., Galera, M. F., & Riegel, M. (2020) · Case Reports in Genetics · doi:10.1155/2020/5957415 · Cited by 6
Analysis of Blood Gene Expression Data Toward Early Detection of Alzheimer’s DiseasePreprint
Gorji, H. T., Kardan, R., & Rezagholizadeh, N. (2021) · medRxiv · doi:10.1101/2021.07.26.21261147 · Cited by 6
Sultana, J., Castaño, J. D., Benkhraba, K., del Castillo, J. R. E., & Beaudry, F. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04445-4 · Cited by 5
“Integrins are transmembrane recep - tors that mediate cell-extracellular matrix interactions and intracellular signaling specifically modulations of Ca 2+ and K + ion channels activity and intracellular calcium concentration [77, 78 ].”
Wijerathne, S. V. T., Pandit, R., Ipinmoroti, A. O., Crenshaw, B. J., & Matthews, Q. L. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1388438 · Cited by 5
“Another tetraspanin-associated marker is CD29 (Integrin-β -1), which plays a crucial role in cell adhesion, organ development, signal transduction, and tissue repair (62, 85, 86).”
BackgroundCollagen VI: Role in synaptic transmission and seizure-related excitability
Ramos‐Moreno, T., Cifra, A., Nikitidou, L., Melin, E., Ahl, M., Christiansen, S. H., Gøtzsche, C. R., Cescon, M., Bonaldo, P., van Loo, K. M. J., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114911 · Cited by 5
Thiere, M., Kliche, S., Müller, B., Teuber, J., Nold, I., & Stork, O. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00091 · Cited by 5
“Neurons express various β1- and β3-integrins (Wu and Reddy, 2012) that interact with the rich extracellular matrix of the nervous system (e.g., fibronectin, laminin, or collagens) and with diffusible factors that serve as guidance cues mediating migration and neurite growth (e.g., netrins,…”
BackgroundGiunti, S., Blanco, M. G., Rosa, M. J. D., & Rayes, D. (2024) · eLife · doi:10.7554/elife.94520 · Cited by 5
Tanaka, M., Ishikane, S., Back, D. J., Licastro, E., Zhang, F., Park, J. H., Esposito, E., Pignataro, G., Nakano, T., Nakamura, Y., et al. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251326871 · Cited by 5
“7,34 Ultimately, future studies are warranted to dissect the mechanisms of cell-to-cell interaction required for phagocytosis and recycling exocytosis of mitochondria in macrophages in the context of CNS injury.”
Rizvi, S. F. A., Ahmad, M., Munib, F., & Zhang, H. (2022) · Applied Organometallic Chemistry · doi:10.1002/aoc.6569 · Cited by 4
Auditory robustness and resilience in the aging auditory system of the desert locust
Austin, T. T., Thomas, C. L., & Warren, B. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.09.009 · Cited by 4
“After the axons are formed, cell-cell adhesion molecules maintain the nerves integrity (Denda and Reichardt, 2007; Wu and Reddy, 2012).”
Quantitative serum proteome analysis using tandem mass tags in dogs with epilepsy
Baka, R. D., Kuleš, J., Beletić, A. D., Farkaš, V., Maslov, D. R., Ljubić, B. B., Rubić, I., Mrljak, V., McLaughlin, M., Eckersall, P. D., et al. (2023) · Journal of Proteomics · doi:10.1016/j.jprot.2023.105034 · Cited by 4
Li, J., Ji, H., Xu, Y., Yang, J., Zuo, R., Li, N., Rao, K., Yang, J., & Lei, B. (2025) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2025.06.006 · Cited by 4
Филимонов, Д. А., Yevtushenko, S. K., & Fedorova, A. (2023) · Annals of Clinical and Experimental Neurology · doi:10.54101/acen.2023.1.6 · Cited by 4
Tomita, Y., Toriumi, K., Miyashita, M., Suzuki, K., Kawaji, H., Itokawa, M., & Arai, M. (2025) · Schizophrenia · doi:10.1038/s41537-025-00706-x · Cited by 3
Auer, S., Hoffmann, L., Schicht, M., Blümcke, I., & Paulsen, F. P. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1728666 · Cited by 3
Linking genomic and proteomic signatures to brain amyloid burden: insights from GR@ACE/DEGESCO
Puerta, R., de Rojas, I., García‐González, P., Olivé, C., Sotolongo‐Grau, Ó., García‐Sánchez, A., García‐Gutiérrez, F., Montrreal, L., Tartari, J. P., Sanabria, Á., et al. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01581-6 · Cited by 4
“Neuronal cadherins and integrins have been linked to the synaptic process, plasticity and long-term potentiation and modulation of Aβ levels (Asada-Utsugi et al. 2011), while their loss has been correlated to cognitive decline (Terry et al. 1991; Uemura 1998; Wu & Reddy 2012).”
Wang, P., Lü, Y., Yang, R., Chen, Z., Ren, X., Wang, F., Jiao, Y., Ding, Y., Yang, F., Sun, T., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.947732 · Cited by 3
“Moreover, synaptic reorganization promotes the development of the excitatory loop, and Fn and its integrin receptor are known to participate in the pathophysiology of epilepsy (Gall and Lynch, 2004; Dityatev and Fellin, 2008; Wu and Reddy, 2012; Pitkanen et al., 2014).”
BackgroundShahrivar, R. Y., Karami, F., & Karami, E. (2025) · PLoS ONE · doi:10.1371/journal.pone.0319401 · Cited by 3
Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattlePreprint
Eusebi, P. G., Sevane, N., Pizarro, M., Valero, M., & Dunner, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.09.194704 · Cited by 3
Human-specific tandem repeat in CACNA1C modulates responses to neuronal stimulationPreprint
Song, J. H. T., Birey, F., Hung, T.-C., Hall, N., Guenther, C. A., Chen, X., Alkuraya, I. F., Tunbridge, E. M., Haerty, W., Pașca, S. P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.15.676436 · Cited by 3
Cell-generated mechanical forces play a role in epileptogenesis after injury
Dalir, L., Tatic-Lucic, S., & Berdichevsky, Y. (2025) · bioRxiv · doi:10.1016/j.expneurol.2025.115376 · Cited by 2
“Integrins are coupled to cell cytoskeleton via adapter proteins such as vinculin and talin which are mechanosensitive and can initiate mechanotransduction (Wu et al., 2016; Wu and Reddy, 2012; Pillai and Franze, 2024).”
Yadav, N., Priya, Dixit, N., Anand, S., Banerjee, J., Tripathi, M., Chandra, P. S., Doddamani, R. S., Sharma, M. C., Lalwani, S., et al. (2026) · Neurochemical Research · doi:10.1007/s11064-025-04656-9 · Cited by 2
“FN1–α5β1 integrin signal - ing has been linked to granule cell plasticity during epi-leptogenesis, where disrupting this interaction suppresses excitability [17 ].”
InfluentialStarck, L., Butelmann, T., Hogan, S. A., Sarem, M., Heimrich, B., Sawarkar, R., Ritz, M., Hütter, G., & Shastri, V. P. (2026) · Advanced Science · doi:10.1002/advs.202509362 · Cited by 3
“…inhibitor of Piezo-1, known to reversibly inhibit more than 80% of the mechanically induced currents [ 48 ], nor blocking antibody toward α V β 3 [ 49 , 50 ] had any effect on spheroid formation (Supplementary Figure S6 ), suggesting that astrocytes perceive nano-scale cues through a mechanism…”
Liposomal nanoparticles as a drug delivery system for improved treatment of multiple myeloma
Hanafy, N. A. N., & Kölemen, S. (2026) · RSC Advances · doi:10.1039/d5ra09823h · Cited by 2
Singh, S., & Winkelstein, B. A. (2022) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-022-01565-6 · Cited by 3
Elalfy, M. M. (2019) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2019.02.000599 · Cited by 2
Raj, S., & Joshi, A. R. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70183 · Cited by 1
Ding, C., Zhao, J., Zhao, T., Xiao, Y., Li, K., Liu, X., Ge, X., Qin, D., Huang, Z., Zhang, Y., et al. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01459-y · Cited by 1
Pharmacological and Clinical Importance of Integrin Antagonists in Treatment of Cancer
Santhosh, S. R. E. D. (2014) · Journal of Cell Science & Therapy · doi:10.4172/2157-7013.1000193 · Cited by 1
“Integrin α6β4 along with ERBB2 in breast cancer and α1 activated KRAS-G12D- induce tumors in the lung [3,4,8,9].”
BackgroundGarcés-Vieira, M. V., & Suárez-Escudero, J. C. (2014) · Dialnet (Universidad de la Rioja) · Cited by 1
Biophysical basis for the induction of glioblastoma-like phenotype in astrocytesPreprint
Starck, L., Sarem, M., Heimrich, B., Sawarkar, R., Ritz, M., Hütter, G., & Shastri, V. P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.31.551259 · Cited by 1
Giunti, S., Blanco, M. G., Rosa, M. J. D., & Rayes, D. (2024) · eLife · doi:10.7554/elife.94520.2 · Cited by 1
Connecting genomic and proteomic signatures of amyloid burden in the brainPreprint
Puerta, R., de Rojas, I., García‐González, P., Olivé, C., Sotolongo‐Grau, Ó., García‐Sánchez, A., García‐Gutiérrez, F., Montrreal, L., Tartari, J. P., Sanabria, Á., et al. (2024) · medRxiv · doi:10.1101/2024.09.06.24313124 · Cited by 1
“Neuronal cadherins and integrins have been linked to the synaptic process, plasticity and long-term potentiation and modulation of Aβ levels 110 , while their loss has been correlated to cognitive decline 111–113 .”
The regulation of focal adhesion kinase by the scaffolding protein RACK1
Dwane, S. (2013) · University of Limerick Institutional Repository (University of Limerick) · doi:10.34961/6252
Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury
Dardiotis, E., Siokas, V., Aloizou, A., Karampinis, E., Brotis, A. G., Grigoriadis, S., Paterakis, K. N., Dardioti, M., Komnos, A., Kapsalaki, E. Z., et al. (2019) · Brain Injury · doi:10.1080/02699052.2019.1606444
“Integrins could be a part of a potential therapeutic approach after TBI (65), as they possess a key role in the neuronal structure and the function of neuroplasticity (18,65,66), a procedure that seems to take place after a TBI, in order to contribute to the functional recovery, reorganization (67) and regeneration of…”
BackgroundNon-synaptic Antiepileptic Effect of Leucurogin on Epileptiform Activity
Oliveira, J. F., Santos, L. E. C., Pesquero, J. L., SANTOS, I. C., Cardoso, J. P., de Oliveira, A. L. R., Fernandes, V. A., Pessoa, R. M., & Almeida, A. C. (2019) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-981-13-2517-5_93
Attributes of Astrocyte Response to Mechano-Stimulation by High-Rate Overpressure
Hlavac, N. (2018) · VTechWorks (Virginia Tech)
Филимонов, Д. А., & Yevtushenko, І. А. (2021) · INTERNATIONAL NEUROLOGICAL JOURNAL · doi:10.22141/2224-0713.17.1.2021.226915
Molnár, Z., Hoerder‐Suabedissen, A., & Hayashi, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735265206.793557828
Gene Expression Profiles Underlying Aggressive Behavior in the Prefrontal Cortex of CattlePreprint
Eusebi, P. G., Sevane, N., ́Rourke, T. O., Pizarro, M., Boeckx, C. A., & Dunner, S. (2021) · Research Square · doi:10.21203/rs.3.rs-146648/v1
Bhuiyan, P., Khan, M. A., Sun, Z., & Qian, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2070137/v1
Wu, X. Y., Trzeciakowski, J. P., Meininger, G. A., & Muthuchamy, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.15.516690
“The integrin ligands might be the potential drug candidates for the treatment and/or prevention of human diseases including diabetes and cardiovascular diseases (7, 19, 22, 37, 87, 96, 99).”
BackgroundSelf-citationAuditory Robustness and Resilience in an Aging Auditory SystemPreprint
Austin, T. T., Thomas, C. L., & Warren, B. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4516613
Rahmi, U., Goenawan, H., Sylviana, N., Setiawan, S., & Ray, H. R. D. (2023) · Journal of Law and Sustainable Development · doi:10.55908/sdgs.v11i10.1074
Giunti, S., Blanco, M. G., Rosa, M. J. D., & Rayes, D. (2024) · eLife · doi:10.7554/elife.94520.1
Jiang, H., Tang, B., Li, K., Zhang, L., Liang, J., Tang, C. S.-M., Tam, P. K. H., Wang, B., Song, Y., Wang, Q., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.17.628845
Convergent Pathways Identified for Cannabis Use Disorder Across Diverse Ancestry PopulationsPreprint
Peng, Q., Wilhelmsen, K. C., & Ehlers, C. L. (2025) · medRxiv · doi:10.1101/2025.03.16.25324078
“As cell surface receptors, integrins are crucial to the pathophysiology of various brain diseases and are considered potential drug targets for neurological disorders [Wu and Reddy, 2012].”
The contribution of fibronectin in epileptogenesis: therapeutic potential and mechanistic complexity
Dixit, N., Yadav, N., Priya, Banerjee, J., Tripathi, M., Chandra, P., & Dixit, A. B. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2557276
“Although less studied in epilepsy than α5β1, these integrins may contribute to cell-ECM connection remodeling during epileptogenesis [28,30].”
InfluentialAcosta, G. T., Yang, S., Calvo-Marín, J., Moghekar, A., Kamalian, A., & Lutz, M. W. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.10.004
Eusebi, P. G., Sevane, N., ́Rourke, T. O., Pizarro, M., Boeckx, C. A., & Dunner, S. (2021) · Figshare · doi:10.6084/m9.figshare.14385600
Jiang, H., Tang, B., Li, K., Zhang, L., Liang, J., Tang, C. S.-M., Tam, P. K. H., Wang, B., Song, Y., Wang, Q., et al. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf135
“ITGB6 encodes a subunit of the integrin, a family of cell-surface adhesion receptors that is likely to contribute to imbalanced synaptic function in AD [60].”
Sun, F., Kang, H., Wang, C., Li, P., Attila Gabor, S. I. K., Liu, K., Li, X., & Jin, M. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202503023
“Research indicates that disrupting the interaction between cellular membrane-associated proteins and ECM may influence neuronal excitability and synaptic plasticity [ 29 ].”
Bhatia, P., Rosales, J. P., Patel, P., Brini, G., Singh, J., Patel, R., Petroski, J., Brisman, B., Sandhu, M., Santacroce, N., et al. (2026) · Cureus · doi:10.7759/cureus.104771
RESOLFT Nanoscopy to study cellular adhesions
Jose, A. A. (2019) · theses.fr (ABES) · doi:10.70675/d6fbf08bzee47z47a5z86c3za85d3833c53d
Chen, Z.-M., Li, M.-Q., Jiang, J.-X., Mo, Y.-H., Li, D.-W., Li, H.-Y., & Yang, W. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128547
Wu, C., Wang, H., Su, Y.-T., Ho, Y., Hsieh, Y.-C., Liang, C.-L., Lee, Y., Chu, T., Lin, Y.-S., & Chen, J. (2026) · Antioxidants · doi:10.3390/antiox15070822
“His–Ser–Arg–Asn), located within the type III domain, enhances α 5 β 1 binding through synergy with the RGD motif and modulates integrin-mediated adhesion, signaling, and cytoskeletal dynamics [13,25–28].”
Li, J., Ji, H., Liu, Y., Li, Z., Fang, Y., Li, N., Rao, K., Zhang, L., & Yu, Y. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c07562
The IKC-leptin axis functions as a molecular bridge between neurodevelopment and endocrine signaling
Forzisi, E., Gaur, A., Gaur, A., Medranda, M. D. C., Philip, R., Anand, S., Impaloni, C., Leonard, K. T., Venkateswaran, S., & Sesti, F. (2026) · iScience · doi:10.1016/j.isci.2026.117851
“46 The effects of these treatments, alone or in combination with leptin or Allo-aca, on the SIP, apical dendrite length, actin aggregates, and the FRAP mobile fraction are summarized in Figure 9.”
Metadata
- Authors
- Wu, X., & Reddy, D. S.
- Affiliations
- Texas A&M Health Science Center (US)
- Corresponding author
- Reddy, Doodipala Samba
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 134
- Issue
- 1
- Pages
- 68-81
- ISSN
- 0163-7258 (ISSN-L)
- PMC
- PMC3288359
- OpenAlex
- W2015445832
- Cited by
- 175
- References
- 202
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 12 · 2023: 16 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 21 · 2018: 14 · 2017: 5 · 2016: 10 · 2015: 5 · 2014: 8 · 2013: 8 · 2012: 4
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS051398, NS051398)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- integrins, neuroplasticity, neurological disorders, extracellular matrix, cell-cell adhesion, cell-matrix adhesion, integrin clustering, epilepsy, traumatic brain injury, seizures, therapeutic target, drug delivery, cytoskeletal remodeling, calcium signaling, protein kinase signaling
- MeSH terms
- Animals, Brain Diseases, Humans, Integrins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
