The DOI matches its Crossref record; 199 of the 202 references it cites were found in a registry or an index.
Integrins as receptor targets for neurological disorders
Open accessAbstract
This review focuses on the neurobiology of integrins, pathophysiological roles of integrins in neuroplasticity and nervous system disorders, and therapeutic implications of integrins as potential drug targets and possible delivery pathways. Neuroplasticity is a central phenomenon in many neurological conditions such as seizures, trauma, and traumatic brain injury. During the course of many brain diseases, in addition to intracellular compartment changes, alterations in non-cell compartments such as extracellular matrix (ECM) are recognized as an essential process in forming and reorganizing neural connections. Integrins are heterodimeric transmembrane receptors that mediate cell-ECM and cell-cell adhesion events. Although the mechanisms of neuroplasticity remain unclear, it has been suggested that integrins undergo plasticity including clustering through interactions with ECM proteins, modulating ion channels, intracellular Ca(2+) and protein kinase signaling, and reorganization of cytoskeletal filaments. As cell surface receptors, integrins are central to the pathophysiology of many brain diseases, such as epilepsy, and are potential targets for the development of new drugs for neurological disorders.
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“Among the top enriched up-regulated pathways in the aggressive Lidia group, the integrin and Alzheimer disease-presenilin signaling pathways are well-known gene routes in the development of abnormal aggressive behaviors [48] (Table 3).”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [48]
In the citing paper
“Increased expression of integrins contributes to imbalanced synaptic function in specific pathological conditions, such as Alzheimer disease and schizophrenia, both often accompanied by episodic aggression and violence [48].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [48]
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Cites
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“…Ca2+ and K+ ion channels, intracellular Ca2+ concentrations, cellular contractile properties, protein kinase activity, and growth factor receptors (Hynes, 1992; Yip & Marsh, 1997; Porter & Hogg, 1998; Wu et al., 1998; Barouch et al., 2000; Chan et al., 2001; Danen & Yamada, 2001; Davis et al.,…”
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“Co-stimulation of integrins and epidermal growth factor (EGF) receptors activates Pyk2 and FAK to promote outgrowth of neurite via paxillin induced cytoskeletal changes (Ivankovic-Dikic et al., 2000).”
Mechanotransduction Across the Cell Surface and Through the Cytoskeleton
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“This signal transduction has been also shown to result in protein phosphorylation, increased intracellular calcium concentration, activation of glutamate receptor, gene transcription, and the release of neurotransmitters (Clark & Brugge, 1995).”
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“The third strategy is to bypass the BBB and deliver the drugs to CNS through an intraventricular/intrathecal route, the olfactory pathway, an interstitial/intracranial drug delivery via releasing drugs from biological tissues, nanoparticles and pumps.”
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Cited by
Sorted by citations
Ludwig, B. S., Kessler, H., Kossatz, S., & Reuning, U. (2021) · Cancers · doi:10.3390/cancers13071711 · Cited by 244
“Most of the eight RGD binding integrins are expressed at elevated levels in various cancer types where they contribute to crucial pathophysiological functions in cancer as well as in other diseases, such as neurological disorders [36], sepsis [37], fibrosis [38], cardiovascular diseases [39], and viral infections [40].”
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Sulfonylurea Receptor 1 in Central Nervous System Injury: A Focused Review
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“Mechanosensitive activation of these transcription factors likely occurs via integrins, the family of extracellular matrix receptors that has been widely implicated in a range of functions including gene expression, cell proliferation, migration and differentiation, and cell survival (Wu and Reddy, 2012).”
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“Integrins are known to control cell development, mediate cell interaction and modulate immune signalling in glial cells [29].”
Background
Metadata
- Authors
- Wu, X., & Reddy, D. S.
- Affiliations
- Texas A&M Health Science Center (US)
- Corresponding author
- Reddy, Doodipala Samba
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 134
- Issue
- 1
- Pages
- 68-81
- ISSN
- 0163-7258 (ISSN-L)
- PMC
- PMC3288359
- OpenAlex
- W2015445832
- Cited by
- 175
- References
- 202
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 12 · 2023: 16 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 21 · 2018: 14 · 2017: 5 · 2016: 10 · 2015: 5 · 2014: 8 · 2013: 8 · 2012: 4
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS051398, NS051398)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- integrins, neuroplasticity, neurological disorders, extracellular matrix, cell-cell adhesion, cell-matrix adhesion, integrin clustering, epilepsy, traumatic brain injury, seizures, therapeutic target, drug delivery, cytoskeletal remodeling, calcium signaling, protein kinase signaling
- MeSH terms
- Animals, Brain Diseases, Humans, Integrins
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