The DOI matches its Crossref record; 256 of the 256 references it cites were found in a registry or an index.
GDNF, NGF and BDNF as therapeutic options for neurodegeneration
Abstract
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival, maintenance and regeneration of specific neuronal populations in the adult brain. Depletion of these neurotrophic factors has been linked with disease pathology and symptoms, and replacement strategies are considered as potential therapeutics for neurodegenerative diseases such as Parkinson's, Alzheimer's and Huntington's diseases. GDNF administration has recently been shown to be an effective treatment for Parkinson's disease, with clinical trials currently in progress. Trials with NGF for Alzheimer's disease are ongoing, with some degree of success. Preclinical results using BDNF also show much promise, although there are accompanying difficulties. Ultimately, the administration of a therapy involving proteins in the brain has inherent problems. Because of the blood-brain-barrier, the protein must be infused directly, produced by viral constructs, secreted from implanted protein-secreting cells or actively transported across the brain. An alternative to this is the use of a small molecule agonist, a modulator or enhancer targeting the associated receptors. We evaluate these neurotrophic factors as potential short or long-term treatments, weighing up preclinical and clinical results with the possible effects on the underlying neurodegenerative process.
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“Neurotrophic factors, such as BDNF and GDNF, have been shown to protect dopaminergic neurons in PD mice by preventing neuronal death [31,32].”
From Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson’s Disease (2022) · cites this paper as [32]
In the citing paper
“Furthermore, it was shown that neurodegenerative and neuropsychiatric diseases may be partially caused by defects in synaptic plasticity associated with the insufficient neuronal supply of BDNF and other neurotrophic factors [11,12,13].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [13]
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Metadata
- Authors
- Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K.
- Affiliations
- Frenchay Hospital (GB)
- Corresponding author
- Allen, Shelley J.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 138
- Issue
- 2
- Pages
- 155-175
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2006376003
- Cited by
- 820
- References
- 256
- Citations by year
- 2026: 42 · 2025: 68 · 2024: 80 · 2023: 74 · 2022: 64 · 2021: 68 · 2020: 49 · 2019: 56 · 2018: 66 · 2017: 53 · 2016: 71 · 2015: 48 · 2014: 63 · 2013: 17
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- glial cell line-derived neurotrophic factor, nerve growth factor, brain-derived neurotrophic factor, neurotrophic factors, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, Huntington's disease, blood-brain barrier, viral gene therapy, small molecule agonists, neurotrophin receptors
- MeSH terms
- Animals, Humans, Ligands, Models, Molecular, Nerve Growth Factors, Brain-Derived Neurotrophic Factor, Neurodegenerative Diseases, Glial Cell Line-Derived Neurotrophic Factor
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