Cited by 77Parkinson's Disease Mechanisms and TreatmentsProbiotics and Fermented FoodsGut microbiota and health

Polymannuronic Acid Prebiotic plus Lacticaseibacillus Rhamnosus GG Probiotic as a Novel Synbiotic Promoted Their Separate Neuroprotection against Parkinson’s Disease

Liu, Xin, Du, Zhong Rui, Wang, Xiong, Sun, Xiang Rong, Zhao, Qing, Zhao, Fang, Wong, Wing Tak, Wong, Ka Hing +1 more·2022·Food Research International

Abstract

Gut microbiota (GM) dysbiosis plays key roles in aggravating Parkinson's disease (PD) and discovery of agents targeting GM may open new avenues for PD therapy. This study aims to investigate the potentially neuroprotective effects and underlying mechanisms of polymannuronic acid (PM) or Lacticaseibacillus rhamnosus GG (LGG), or their combination in a chronic PD mice model. Our results found oral administration of prebiotic PM or LGG separately or in combination for 5 weeks could prevent dopaminergic neuronal loss via improving reduced walking distance and activity or weakened muscle strength in behavior tests by enhancing tyrosine hydroxylase (TH) gene and/or protein expressions in the midbrain and striatum of PD mice. Strikingly, PM and LGG in combination had a much better neuroprotective effects than separate PM or LGG. PM provided neuroprotection via a short chain fatty acids (SCFAs)-mediated anti-inflammation and anti-apoptosis mechanism. The neuroprotective effects of LGG might be associated with its ability to improve the expression of striatal glial cell-derived neurotrophic factor (GDNF) and to increase bacteria abundance of Clostridiales. When PD mice were administered with PM + LGG, PM as prebiotic favored bacterial growth (from Bacilli class to Lactobacillus genus) in the colon, which helped to improve blood brain barrier (BBB) integrity and increase brain-derived neurotrophic factor (BDNF) and GDNF expressions, thereby inhibiting apoptosis in the striatum. In conclusion, PM and LGG in combination promoted their separate neuroprotection against PD. Our study discovered and testified a novel synbiotic that might be one of the ideal oral agents for PD therapy.

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Crossref · 10.1016/j.foodres.2022.111067

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Authors
Liu, X., Du, Z. R., Wang, X., Sun, X. R., Zhao, Q., Zhao, F., Wong, W. T., Wong, K. H., & Dong, X.-L.
Affiliations
  • Hong Kong Polytechnic University (HK)
  • Qingdao University (CN)
  • BGI Group (China) (CN)
Corresponding author
  • Wong, Ka Hing
  • Dong, Xiao-Li
Venue
Food Research International
Publisher
Elsevier BV
Published
2022-05
Volume
155
Pages
111067
ISSN
0963-9969 (ISSN-L)
OpenAlex
W4213416177
Cited by
77
References
45
Citations by year
2026: 14 · 2025: 21 · 2024: 22 · 2023: 12 · 2022: 8
FWCI
8.32
Type
journal article
Language
en
Open access
closed
Locations
  • Food Research International (publishedVersion)
  • PubMed (publishedVersion)
Funders
Shenzhen Fundamental Research Program (JCYJ20170818111103886, JCYJ20200109142019319)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Parkinson's disease, Lactobacillus rhamnosus GG, synbiotics, prebiotics, probiotics, neuroprotection, gut dysbiosis, short-chain fatty acids, anti-inflammation, apoptosis inhibition, dopaminergic neuron loss, tyrosine hydroxylase, glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, blood-brain barrier, Clostridiales, Lactobacillus, striatum
MeSH terms
Neuroprotection, Alginic Acid, Animals, Parkinson Disease, Neuroprotective Agents, Probiotics, Glial Cell Line-Derived Neurotrophic Factor, Mice, Lacticaseibacillus rhamnosus, Prebiotics, Synbiotics

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