The DOI matches its Crossref record; 691 of the 697 references it cites were found in a registry or an index.
Neuroscience-driven discovery and development of sleep therapeutics
Abstract
Until recently, neuroscience has given sleep research and discovery of better treatments of sleep disturbances little attention, despite the fact that disturbed sleep has overwhelming impact on human health. Sleep is a complex phenomenon in which specific psychological, electrophysiological, neurochemical, endocrinological, immunological and genetic factors are involved. The brain as both the generator and main object of sleep is obviously of particular interest, which makes a neuroscience-driven view the most promising approach to evaluate clinical implications and applications of sleep research. Polysomnography as the gold standard of sleep research, complemented by brain imaging, neuroendocrine testing, genomics and other laboratory measures can help to create composite biomarkers that allow maximizing the effects of individualized therapies while minimizing adverse effects. Here we review the current state of the neuroscience of sleep, sleep disorders and sleep therapeutics and will give some leads to promote the discovery and development of sleep medicines that are better than those we have today.
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“Based on objective PSG and actigraphy assessment, various indicators of disrupted sleep have been reported in RA patients compared with healthy control participants, including increases in α-EEG intrusion, arousals, sleep stage shifts, sleep fragmentation, and nocturnal wake time (54, 160, 237, 351, 472).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [160]
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Cited by
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
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Metadata
- Authors
- Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Max Planck Society (DE)
- Corresponding author
- Holsboer, F.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 141
- Issue
- 3
- Pages
- 300-334
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2065074889
- Semantic Scholar
- 8f84f6c1b91d3a60af74b2077877bb1add9b2cc1
- Cited by
- 63
- References
- 697
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 5
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep disorders, polysomnography, neuroimaging, composite biomarker, personalized treatment, adverse effects
- MeSH terms
- Animals, Brain, Humans, Neurosciences, Sleep, Sleep Wake Disorders, Drug Design, Polysomnography, Biomedical Research, Neuroimaging
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