The DOI matches its Crossref record; 691 of the 697 references it cites were found in a registry or an index.
Neuroscience-driven discovery and development of sleep therapeutics
Abstract
Until recently, neuroscience has given sleep research and discovery of better treatments of sleep disturbances little attention, despite the fact that disturbed sleep has overwhelming impact on human health. Sleep is a complex phenomenon in which specific psychological, electrophysiological, neurochemical, endocrinological, immunological and genetic factors are involved. The brain as both the generator and main object of sleep is obviously of particular interest, which makes a neuroscience-driven view the most promising approach to evaluate clinical implications and applications of sleep research. Polysomnography as the gold standard of sleep research, complemented by brain imaging, neuroendocrine testing, genomics and other laboratory measures can help to create composite biomarkers that allow maximizing the effects of individualized therapies while minimizing adverse effects. Here we review the current state of the neuroscience of sleep, sleep disorders and sleep therapeutics and will give some leads to promote the discovery and development of sleep medicines that are better than those we have today.
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“Based on objective PSG and actigraphy assessment, various indicators of disrupted sleep have been reported in RA patients compared with healthy control participants, including increases in α-EEG intrusion, arousals, sleep stage shifts, sleep fragmentation, and nocturnal wake time (54, 160, 237, 351, 472).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [160]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
(2007) · Cited by 6,530
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Self-citationGhrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
Research works printed but not linked: 10
- Borbély, 1998, The quest for the essence of sleep, Daedalus, 127, 167
- Brunner, 2001, Sleep parameters in identical twins discordant for schizophrenia, Sleep, 24, A392
- Cartwright, 1972, Problem solving in REM, NREM and waking, Psychophysiology, 9, 108
- Dresler, 2013, Dreaming and psychosis: insight in the brain, Sleep Med Rev
- Gvilia, 2012, Effects of corticotropin releasing factor on sleep homeostatic response and Fos expression in the preoptic hypothalamus, J Sleep Res, 21, S262
- Honda, 1979, Census of narcolepsy, cataplexy and sleep life among teenagers in Fujisawa city, Sleep Res Online, 8, 191
- Jouvet, 1959, Sur un stade d'activité électrique cérebrale rapide an cours du sommeil physiologique, C R Seances Soc Biol Fil, 153, 1024
- Mieda, 2004, Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice, Proc Natl Acad Sci U S A, 101, 4649, 10.1073/pnas.0400590101 · DOI
- Passouant, 1973, La suppression du sommeil paradoxal par la clomipramine, Therapie, 28, 379
- Ströhle, 1999, Hochdosierter Mißbrauch von “Non-Benzodiazepinhypnotika”: Zwei Fallberichte, Nervenarzt, 70, 72
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ISRUC-Sleep: A comprehensive public dataset for sleep researchers
Khalighi, S., Sousa, T., dos Santos, J. M., & Nunes, U. (2015) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2015.10.013 · Cited by 393
“Therefore, the scoring of sleep stages may be challenging [18].”
BackgroundInfluentialGenzel, L., Kroes, M. C. W., Dresler, M., & Battaglia, F. P. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.002 · Cited by 285
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Dresler, M., Wehrle, R., Spoormaker, V. I., Steiger, A., Holsboer, F., Czisch, M., & Hobson, J. A. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.06.004 · Cited by 84
Self-citationWang, Z., Zhang, X., Cui, X., Cui, S., Yu, B., Sheng, Z., Li, S., Cao, Q., Huang, Y., Xu, Y.-P., et al. (2015) · Scientific Reports · doi:10.1038/srep09442 · Cited by 66
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Metzger, M. W., Walser, S. M., Dedic, N., Aprile-Garcia, F., Jakubcakova, V., Adamczyk, M., Webb, K. J., Uhr, M., Refojo, D., Schmidt, M. V., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3487-16.2017 · Cited by 59
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BackgroundBoeselt, T., Koczulla, A. R., Nell, C., Beutel, B., Guenter, K., Cassel, W., Hildebrandt, O., Koehler, U., & Kroenig, J. (2019) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.101434 · Cited by 25
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BackgroundOptimizing the methodology of human sleep and memory research
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“For instance, growth hormone peaks in the first half of the night, whereas its concentration is very low in the second half 57 .”
Self-citationRaymond, J. S., Rehn, S., Hoyos, C. M., & Bowen, M. T. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.016 · Cited by 21
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BackgroundSelf-citationAkyol, S., Yıldırım, M., & Alataş, B. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106768 · Cited by 20
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Self-citationZabrecky, G. P., Shahrampour, S., Whitely, C. B., Alizadeh, M., Conklin, C. J., Wintering, N., Doghramji, K., Zhan, T., Mohamed, F. B., Newberg, A. B., et al. (2020) · Sleep Disorders · doi:10.1155/2020/7846914 · Cited by 17
“Several scholars have recommended the use of neuroimaging techniques to better evaluate therapeutic approaches in sleep disorders [24].”
BackgroundClinical and Experimental Human Sleep-Wake Pharmacogenetics
Landolt, H., Holst, S. C., & Valomon, A. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_175 · Cited by 15
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“Later discoveries identified neurophysiological events within sleep stages such as sleep spindles and slow waves as a marker of non-REM (NREM) sleep, or ponto-geniculo-occipital (PGO) waves, traceable in animal models, during REM sleep (for review, see Dresler et al., 2014).”
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BackgroundInfluentialSelf-citationManagement of Nonmotor Symptoms of Parkinson's Disease
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Jain, K. K. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2553-7_12
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Metadata
- Authors
- Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Max Planck Society (DE)
- Corresponding author
- Holsboer, F.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 141
- Issue
- 3
- Pages
- 300-334
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2065074889
- Semantic Scholar
- 8f84f6c1b91d3a60af74b2077877bb1add9b2cc1
- Cited by
- 63
- References
- 697
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 5
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep disorders, polysomnography, neuroimaging, composite biomarker, personalized treatment, adverse effects
- MeSH terms
- Animals, Brain, Humans, Neurosciences, Sleep, Sleep Wake Disorders, Drug Design, Polysomnography, Biomedical Research, Neuroimaging
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