Inhibitors of cyclin-dependent kinases as cancer therapeutics.
Whittaker, Steven R., Mallinger, Aurélie, Workman, Paul, Clarke, Paul A.·2017·Pharmacology & Therapeutics
Cites (292)
Items 201–285 of 285
- Cdk12 is essential for embryonic development and the maintenance of genomic stabilityH. U. Juan, Yu-Ju Lin, H-R Chen, M-J Fann · 2015 · Cell Death and Differentiation
- Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesPaul Andrew Clarke, Maria-Jesus Ortiz-Ruiz, Robert te Poele, Olajumoke Adeniji-Popoola, Gary Box, Will Court, Stephanie Czasch, Samer El Bawab, Christina Esdar, Kenneth Ewan et al. · 2016 · eLife
- Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor–Positive Breast CancerHetal Patel, Rezvan Faisal Abduljabbar, Chun‐Fui Lai, Manikandan Periyasamy, Alison Harrod, Carolina Gemma, Jennifer H. Steel, Naina R. Patel, Claudia Busonero, Dena A. Jerjees et al. · 2016 · Clinical Cancer Research
- The RNP protein, RNPS1, associates with specific isoforms of the P34CDC2 related PITSLRE protein kinase in vivoPascal Loyer, Janeen H. Trembley, Jill M. Lahti, Vincent J. Kidd · 1998 · Journal of Cell Science
- PITSLRE p110 Protein Kinases Associate with Transcription Complexes and Affect Their ActivityJaneen H. Trembley, Dongli Hu, Li-Chung Hsu, C Y Yeung, Clive Arthur Slaughter, Jill M. Lahti, Vincent J. Kidd · 2002 · Journal of Biological Chemistry
- Amplification of a 280-Kilobase Core Region at the ERBB2 Locus Leads to Activation of Two Hypothetical Proteins in Breast CancerPäivikki Kauraniemi, Tuula Kuukasjärvi, Guido Sauter, Anne H. Kallioniemi · 2003 · American Journal Of Pathology
- Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in IndiaIndranil Chattopadhyay, Avninder Singh, Rupkumar Phukan, Joydeep Purkayastha, Amal Chandra Kataki, Jagadish Mahanta, Sunita Saxena, Sujala Kapur · 2010 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- Efficacy and safety of dinaciclib vs ofatumumab in patients with relapsed/refractory chronic lymphocytic leukemiaPaolo Ghia, Lydia Scarfò, Susan Perez, Kumudu Pathiraja, Martha Derosier, Karen A. Small, Christine McCrary Sisk, Nigel W. Patton · 2017 · Blood
- The p34 -related Cyclin-dependent kinase 11 Interacts with the p47 Subunit of Eukaryotic Initiation Factor 3 during ApoptosisJiaqi Shi, Yongmei Feng, Anne‐Christine Goulet, Richard R. Vaillancourt, Nancy A. Sachs, John W.B. Hershey, Mark A. Nelson · 2003 · Journal of Biological Chemistry
- A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motilityWilson Kin Chung Leung, Arthur K.-K. Ching, Anthony W.H. Chan, Terence Chuen Wai Poon, H Mian, Alice S.T. Wong, Ka‐Fai To, N Wong · 2011 · Oncogene
- A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumorsDaruka Mahadevan, Ruth Plummer, Matthew S. Squires, Diane Rensvold, Sandra E Kurtin, Chris Pretzinger, Tomislav Dragovich, J. Adams, Victoria Lock, Donna-Michelle Smith et al. · 2011 · Annals of Oncology
- Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rateHideki Yokoyama, Oliver J. Gruß, Sofia Rybina, Maïwen Caudron‐Herger, Malgorzata Schelder, Matthias S. Wilm, Iain W. Mattaj, Eric Karsenti · 2008 · The Journal of Cell Biology
- Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1Derrick J. Rossi, Anou Londesborough, Nina Korsisaari, Arno Pihlak, Eero Lehtonen, Mark J. Henkemeyer, Tomi P. Mäkelä · 2001 · The EMBO Journal
- CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndromeVincent J. Guen, Carly Gamble, Marc Flajolet, Sheila Unger, Aurélie Thollet, Yoan Ferandin, Andrea Superti‐Furga, Pascale A. Cohen, Laurent Meijer, Pierre Colas · 2013 · Proceedings of the National Academy of Sciences
- Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanomaSusan Burdette-Radoux, Richard G. Tozer, Reinhard C. Lohmann, Ian C. Quirt, D. Scott Ernst, Wendy Walsh, Nancy Wainman, Alexander Dimitrios Colevas, Elizabeth A. Eisenhauer · 2004 · Investigational New Drugs
- A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabineElisabeth Jane Walsby, Guy Pratt, Hao Shao, Abdullah Y. Abbas, Peter M. Fischer, Tracey Dawn Bradshaw, Paul Brennan, Chris Fegan, Shudong Wang, Chris J. Pepper · 2013 · Oncotarget
- Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell ProliferationKarl A. Merrick, Lara Wohlbold, Chao Zhang, Jasmina J. Allen, Dai Horiuchi, Noelle E. Huskey, Andrei Goga, Kevan M. Shokat, Robert P. Fisher · 2011 · Molecular Cell
- Integrated Analysis of Whole Genome and Transcriptome Sequencing Reveals Diverse Transcriptomic Aberrations Driven by Somatic Genomic Changes in Liver CancersYuichi Shiraishi, Akihiro Fujimoto, Mayuko Furuta, Hiroko Tanaka, Kenichi Chiba, Keith A. Boroevich, Tetsuo Abe, Yoshiiku Kawakami, Masaki Ueno, Kunihito Gotoh et al. · 2014 · PLoS ONE
- Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway ScreenAurélie Mallinger, Simon Crumpler, Mark Pichowicz, Dennis Waalboer, Mark Stubbs, Olajumoke Adeniji-Popoola, Bozena Wood, Elizabeth L. Smith, Ching Thai, Alan T. Henley et al. · 2015 · Journal of Medicinal Chemistry
- Synthesis and Evaluation of Phosphorus Containing, Specific CDK9/CycT1 InhibitorsGábor Németh, Zoltán Greff, Anna Sipos, Zoltán Varga, Rita Székely, Mónika Sebestyén, Zsuzsa M. Jászay, Szabolcs Béni, Zoltán Nemes, Jean‐Luc Pirat et al. · 2014 · Journal of Medicinal Chemistry
- Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout CellsMichael F. T. Koehler, Philippe Bergeron, Elizabeth M. Blackwood, Krista K. Bowman, Kevin Clark, Ron Firestein, James R. Kiefer, K. Maskos, Mark L. McCleland, Linda Orren et al. · 2016 · ACS Medicinal Chemistry Letters
- The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancerYubing Zhou, Jacson K. Shen, Francis John Hornicek, Quancheng Kan, Zhenfeng Duan · 2016 · Oncotarget
- Cdk8 deletion in the ApcMin murine tumour model represses EZH2 activity and accelerates tumourigenesisMark L. McCleland, Tim M. Soukup, Scot D. Liu, Jonathan H. Esensten, Felipe de Sousa e Melo, Murat Yaylaoglu, Søren Warming, Merone Roose‐Girma, Ron Firestein · 2015 · The Journal of Pathology
- Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor CellsTimothy W. R. Kelso, Karen Baumgart, Jan Eickhoff, Thomas Albert, Claudia Antrecht, Sarah Lemcke, Bert Klebl, Michael Meisterernst · 2014 · Molecular and Cellular Biology
- Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activityZhenghu Chen, Zhenyu Wang, Jonathan C. Pang, Yang Yu, Shayahati Bieerkehazhi, Jiaxiong Lu, Ting Hu, Yanling Zhao, Xin Yi Xu, Hong Zhang et al. · 2016 · Scientific Reports
- The CTD code of RNA polymerase II: a structural viewOlga Jasnovidova, Richard Štefl · 2012 · Wiley Interdisciplinary Reviews - RNA
- Cell Cycle-dependent Regulation of the Forkhead Transcription Factor FOXK2 by CDK·Cyclin ComplexesAnett Marais, Zongling Ji, Emma S. Child, Eberhard Krause, David J. Mann, Andrew D Sharrocks · 2010 · Journal of Biological Chemistry
- CDK1 Is a Synthetic Lethal Target for KRAS Mutant TumoursSara Costa-Cabral, Rachel Brough, Asha Konde, Marieke Aarts, James Campbell, Eliana Marinari, Jenna L. Riffell, Alberto Bardelli, Christopher J. Torrance, Christopher J. Lord et al. · 2016 · PLoS ONE
- CDK8 kinase—An emerging target in targeted cancer therapyTomasz Rzymski, Michał Mikuła, Katarzyna Wiklik, Krzysztof D. Brzózka · 2015 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- CDK8 regulates E2F1 transcriptional activity through S375 phosphorylationJia Zhao, Robert Ramos, Mark J. Demma · 2012 · Oncogene
- The use of genetic programming in the analysis of quantitative gene expression profiles for identification of nodal status in bladder cancerAnirban Pradip Mitra, Arpit A. Almal, Ben George, David W. Fry, Peter F. Lenehan, Vincenzo Pagliarulo, Richard J. Côté, Ram H. Datar, William P. Worzel · 2006 · BMC Cancer
- Cyclin-dependent kinase 11p110 (CDK11p110) is crucial for human breast cancer cell proliferation and growthYubing Zhou, Chao Han, Duolu Li, Zujiang Yu, Fengmei Li, Feng Li, Qi An, Huili Bai, Xiaojian Zhang, Zhenfeng Duan et al. · 2015 · Scientific Reports
- A Phase I study of cyclin-dependent kinase inhibitor, AT7519, in patients with advanced cancer: NCIC Clinical Trials Group IND 177E X Chen, Sebastién J. Hotte, Hal W. Hirte, Lillian L. Siu, J Lyons, Matthew S. Squires, Sonya Lovell, S Turner, L McIntosh, Lesley Seymour · 2014 · British Journal of Cancer
- Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapyBetsy T. Kren, Gretchen M. Unger, Md. Joynal Abedin, Rachel Isaksson Vogel, Christine M. Henzler, Khalil Ahmed, Janeen H. Trembley · 2015 · Breast Cancer Research
- Systematic Kinome shRNA Screening Identifies CDK11 (PITSLRE) Kinase Expression Is Critical for Osteosarcoma Cell Growth and ProliferationZhenfeng Duan, Jianming Zhang, Edwin Choy, David C. Harmon, Xianzhe Liu, Petur Nielsen, Henry J. Mankin, Nathanael S. Gray, Francis John Hornicek · 2012 · Clinical Cancer Research
- A Phase II Trial of Flavopiridol (NSC #649890) in Patients with Previously Untreated Metastatic Androgen-Independent Prostate CancerGlenn Liu, David R. Gandara, Primo N. Lara, Derek Raghavan, James H. Doroshow, Przemyslaw W. Twardowski, Philip W. Kantoff, William K. Oh, KyungMann Kim, George Wilding · 2004 · Clinical Cancer Research
- Dual Targeting of CDK and Tropomyosin Receptor Kinase Families by the Oral Inhibitor PHA-848125, an Agent with Broad-Spectrum Antitumor EfficacyClara Albanese, Rachele Alzani, Nadia Amboldi, Nilla Roberta Avanzi, Dario Ballinari, Maria Gabriella Brasca, Claudio Festuccia, Francesco Fiorentini, Giuseppe Locatelli, Wilma Pastori et al. · 2010 · Molecular Cancer Therapeutics
- Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent NeuroblastomaM. Emmy M. Dolman, Evon Poon, Marli E. Ebus, Ilona J.M. den Hartog, Carel J.M. van Noesel, Yann Jamin, Albert Hallsworth, Simon P. Robinson, Kevin R. Petrie, Rolf W. Sparidans et al. · 2015 · Clinical Cancer Research
- Cross-talk Among RNA Polymerase II Kinases Modulates C-terminal Domain PhosphorylationBallachanda N. Devaiah, Dinah S. Singer · 2012 · Journal of Biological Chemistry
- Cyclin-Dependent Kinase 12 Increases 3′ End Processing of Growth Factor-Induced c-FOS TranscriptsTristan Eifler, Wei Shao, Koen Bartholomeeusen, Koh Fujinaga, Stefanie Jäger, Jeffrey R. Johnson, Zeping Luo, Nevan J. Krogan, Boris Matija Peterlin · 2014 · Molecular and Cellular Biology
- CDKI‐71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridolXiangrui Liu, Shenhua Shi, Frankie Lam, Chris J. Pepper, Peter M. Fischer, Shudong Wang · 2011 · International Journal of Cancer
- Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients with advanced solid tumoursDavid S. Boss, Gary K. Schwartz, Mark Ross Middleton, Dereck Dokyi Amakye, Helen Swaisland, Rachel S. Midgley, Malcolm Ranson, Sarah J. Danson, Hilary Calvert, Ruth Plummer et al. · 2009 · Annals of Oncology
- Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8Philippe Bergeron, Michael F. T. Koehler, Elizabeth M. Blackwood, Krista K. Bowman, Kevin Clark, Ron Firestein, James R. Kiefer, K. Maskos, Mark L. McCleland, Linda Orren et al. · 2016 · ACS Medicinal Chemistry Letters
- Phosphorylation of RNAPIIBartlomiej Bartkowiak, Arno L. Greenleaf · 2011 · Transcription
- The Cyclin-Dependent Kinase Inhibitor Seliciclib (R-roscovitine; CYC202) Decreases the Expression of Mitotic Control Genes and Prevents Entry into MitosisSteven R. Whittaker, Robert te Poele, Florence Chan, Spiros Linardopoulos, Michael I. Walton, Michelle Dawn Garrett, Paul Workman · 2007 · Cell Cycle
- Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cellsBin Jia, Edwin Choy, Gregory Michael Cote, David C. Harmon, Shunan Ye, Quancheng Kan, Henry J. Mankin, Francis John Hornicek, Zhenfeng Duan · 2013 · Cancer Letters
- AT7519, a Cyclin-Dependent Kinase Inhibitor, Exerts Its Effects by Transcriptional Inhibition in Leukemia Cell Lines and Patient SamplesMatthew S. Squires, Laurence S. Cooke, Victoria Lock, Wenqing Qi, Edward J. Lewis, Neil T. Thompson, John F. Lyons, Daruka Mahadevan · 2010 · Molecular Cancer Therapeutics
- Cyclin Dependent Kinase 11 in RNA Transcription and SplicingJaneen H. Trembley, Pascal Loyer, Dongli Hu, Tongyuan Li, Jose A. Grenet, Jill M. Lahti, Vincent J. Kidd · 2004 · Progress in nucleic acid research and molecular biology
- Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73Frankie Lam, Abdullahi Yahya Abbas, Hao Shao, Theodosia Teo, Julian Adams, Peng Li, Tracey Dawn Bradshaw, Peter M. Fischer, Elisabeth Jane Walsby, Chris J. Pepper et al. · 2014 · Oncotarget
- Expression, Purification, and Identification of Associated Proteins of the Full-length hCDK12/CyclinK ComplexBartlomiej Bartkowiak, Arno L. Greenleaf · 2014 · Journal of Biological Chemistry
- Mitosis-Specific Phosphorylation of Nucleolin by p34 cdc2 Protein KinasePascale Belenguer, Michèle Caizergues‐Ferrer, Jean‐Claude Labbé, Marcel Dorée, François Amalric · 1990 · Molecular and Cellular Biology
- Roles of cyclin-dependent kinase 8 and β-catenin in the oncogenesis and progression of gastric adenocarcinomaLim · 2011 · International Journal of Oncology
- Abstract CT101: Final results of a randomized Phase II study of PD 0332991, a cyclin-dependent kinase (CDK)-4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER+/HER2- advanced breast cancer (PALOMA-1; TRIO-18)Richard S. Finn, John Paul Crown, István Láng, Katalin Boér, Igor M. Bondarenko, Sergey O. Kulyk, Johannes Ettl, Ravindranath Patel, Tamás Pintér, Marcus Schmidt et al. · 2014 · Cancer Research
- Selective control of gene expression by CDK9 in human cellsJudit Garriga, Hongbo Michael Xie, Zoran Obradovic A, Xavier Graña · 2009 · Journal of Cellular Physiology
- PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinomaTingting Sun, Ngai Na Co, Nathalie Wong · 2014 · Biochemical and Biophysical Research Communications
- Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases*Jun Yang, Yingxin Zhao, Mridul Kumar Kalita, Xueling Li, Mohammad Jamaluddin, Bing Tian, Chukwudi B. Edeh, John E. Wiktorowicz, Andrzej S. Kudlicki, Allan R. Brasier · 2015 · Molecular & Cellular Proteomics
- Engineering an analog-sensitive CDK12 cell line using CRISPR/CasBartlomiej Bartkowiak, Christopher M. Yan, Arno L. Greenleaf · 2015 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Tumor-suppressive effects of CDK8 in endometrial cancer cellsWeiting Gu, Chenguang Wang, Weihua Li, Fu-Ning Hsu, Lifeng Tian, Jie Zhou, Cunzhong Yuan, Xiao-Jun Xie, Tao Jiang, Sankar Addya et al. · 2013 · Cell Cycle
- PFTK1 Promotes Gastric Cancer Progression by Regulating Proliferation, Migration and InvasionLei Yang, Jia Yun Zhu, Hua Huang, Qichang Yang, Jing Cai, Qiuhong Wang, Junya Zhu, Mengting Shao, Jinzhang Xiao, Jie Cao et al. · 2015 · PLoS ONE
- 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19Aurélie Mallinger, Kai Schiemann, Christian Rink, Jimmy J. P. Sejberg, Mark A. Honey, Paul Czodrowski, Mark Stubbs, Oliver Poeschke, Michael Busch, Richard Schneider et al. · 2016 · ACS Medicinal Chemistry Letters
- Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivoEmiliano Cocco, Salvatore Lopez, Jonathan Black, Stefania Bellone, Elena Bonazzoli, Federica Predolini, Francesca Ferrari, Carlton L. Schwab, Gulden Menderes, Luca Arrigo Zammataro et al. · 2016 · British Journal of Cancer
- Role of CDK8 and β-catenin in colorectal adenocarcinomaLim · 2010 · Oncology Reports
- Cdk9 T‐loop phosphorylation is regulated by the calcium signaling pathwayRajesh Ramakrishnan, Andrew P. Rice · 2011 · Journal of Cellular Physiology
- Zooming in on Transcription PreinitiationKapil Gupta, Duygu Sari, Matthias Haffke, Simon Trowitzsch, Imre Berger · 2016 · Journal of Molecular Biology
- LY2835219, a novel cell cycle inhibitor selective for CDK4/6, in combination with fulvestrant for patients with hormone receptor positive (HR+) metastatic breast cancerPatnaik, Amita, Rosen, Lee S., Tolaney, Sara M., Tolcher, Anthony W., Goldman, Jonathan Wade, Gandhi, Leena, Papadopoulos, Kyriakos P., Beeram, Muralidhar, Rasco, Drew Warren, Myrand, Scott P. et al. · 2014 · Journal of Clinical Oncology
- Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignanciesGlen J. Weiss, Manuel M. Hidalgo, Mitesh J. Borad, Daniel A. Laheru, Raoul Tibes, Ramesh K. Ramanathan, Lisa Blaydorn, Gayle Jameson, Antonio Jimeno, Jeffrey D. Isaacs et al. · 2011 · Investigational New Drugs
- Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophoreKai Schiemann, Aurélie Mallinger, Dirk Wienke, Christina Esdar, Oliver Poeschke, Michael Busch, Felix Rohdich, Suzanne A. Eccles, Richard Schneider, Florence I. Raynaud et al. · 2016 · Bioorganic & Medicinal Chemistry Letters
- CDK11p58 Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic CentrosomesNathalie Franck, Émilie Montembault, Pierre Romé, Aude Pascal, Jean-Yves Crémet, Régis Giet · 2011 · PLoS ONE
- The cyclin-dependent kinase 11p46 isoform interacts with RanBPMMonika Mikołajczyk, Jiaqi Shi, Richard R. Vaillancourt, Nancy A. Sachs, Mark A. Nelson · 2003 · Biochemical and Biophysical Research Communications
- Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16‐dependent transcriptional regulationTaiki Tsutsui, Hiroyasu Umemura, Aki Tanaka, F. Mizuki, Yutaka Hirose, Y. Ohkuma · 2008 · Genes to Cells
- The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cellsKatja Storch, Nils Cordes · 2015 · International Journal of Oncology
- PCTAIRE1/PCTK1/CDK16: a new oncotarget?Teruki Yanagi, Shu‐ichi Matsuzawa · 2015 · Cell Cycle
- Gene‐specific requirement of RNA polymerase II CTD phosphorylationJulie Drogat, Damien Hermand · 2012 · Molecular Microbiology
- Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitorsStuart C. Wilson, Butrus Atrash, Clare Barlow, Susan Eccles, Peter M. Fischer, Angela Hayes, Lloyd R. Kèlland, Wayne Jackson, Michael Jarman, Amin R. Mirza et al. · 2011 · Bioorganic & Medicinal Chemistry
- A phase I study of R547, a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs)S. Diab, S. Gail Eckhardt, Antoinette R. Tan, Gary Frenette, Lia Gore, Wanda DePinto, Joseph F. Grippo, Mark DeMario, Stanislaw M. Mikulski, S. Papadimitrakopoulou · 2007 · Journal of Clinical Oncology
- Identification of murine cdk10: Association with Ets2 transcription factor and effects on the cell cycleLuigi Bagella, Cristina Giacinti, Cristiano Simone, Antonio Giordano · 2006 · Journal of Cellular Biochemistry
- CDK11p58 kinase activity is required to protect sister chromatid cohesion at centromeres in mitosisTarik Rakkaa, Christophe Escudé, Régis Giet, Laura Magnaghi-Jaulin, Christian Jaulin · 2014 · Chromosome Research
- CRK7 modifies the MAPK pathway and influences the response to endocrine therapyElizabeth J. Iorns, Sanne R. Martens‐de Kemp, Christopher J. Lord, Alan Ashworth · 2009 · Carcinogenesis
- A phase II randomized study of oral seliciclib in patients with previously treated nasopharyngeal carcinomaWinnie Yeo, Boon Cher Goh, Christophe Le Tourneau, S.R. Green, Judy H. Chiao, Lillian L. Siu · 2009 · Journal of Clinical Oncology
- A Phase 3 Study to Evaluate the Efficacy and Safety of Dinaciclib Compared to Ofatumumab in Patients with Refractory Chronic Lymphocytic LeukemiaPaolo Ghia, Lydia Scarfò, Kumudu Pathiraja, Martha Derosier, Karen A. Small, Nigel W. Patton · 2015 · Blood
- Phase I study of sapacitabine and seliciclib in patients with advanced solid tumors.Sara M. Tolaney, John Frederick Hilton, James M. Cleary, Leena Gandhi, Eunice Lee Kwak, Jeffrey William Clark, Andrew Wolanski, Tracy Demeo Bell, Scott J. Rodig, Judy H. Chiao et al. · 2016 · Journal of Clinical Oncology
- Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells.Zhi-Qiang Wang, Casey L Johnson, Amit Kumar, David P. Molkentine, Jessica M. Molkentine, Tatiana Rabin, Kathryn A. Mason, Luka Milas, Uma Raju · 2014 · PubMed
- CYC065, potential therapeutic agent for AML and MLL leukaemiaSheelagh Frame, Chiara Saladino, Susan Davis, David Blake, Daniella I. Zheleva · 2015 · Clinical Lymphoma Myeloma & Leukemia
- A first-in-human phase I study of oral pan-CDK inhibitor BAY 1000394 in patients with advanced solid tumors: Dose escalation with an intermittent 3 days on/4 days off schedule.Rastislav Bahleda, Anas Gazzah, Andréa Varga, Prabhu Rajagopalan, David Andrew Henderson, Martin Kornacker, Jean‐Charles Soria · 2012 · Journal of Clinical Oncology
- Abstract 562: Dinaciclib induces immunogenic cell death and enhances anti-PD-1 mediated tumor suppressionDewan Hossain, Fernando Ugarte, Anandi Sawant, Mingmei Cai, Venkataraman Sriram, Elaine M. Pinheiro, Svetlana Sadekova, Alissa A. Chackerian · 2016 · Cancer Research