The DOI matches its Crossref record; 359 of the 359 references it cites were found in a registry or an index.
Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders
Open accessAbstract
Recent extensive evidence indicates that air pollution, in addition to causing respiratory and cardiovascular diseases, may also negatively affect the brain and contribute to central nervous system diseases. Air pollution is comprised of ambient particulate matter (PM) of different sizes, gases, organic compounds, and metals. An important contributor to PM is represented by traffic-related air pollution, mostly ascribed to diesel exhaust (DE). Epidemiological and animal studies have shown that exposure to air pollution may be associated with multiple adverse effects on the central nervous system. In addition to a variety of behavioral abnormalities, the most prominent effects caused by air pollution are oxidative stress and neuro-inflammation, which are seen in both humans and animals, and are supported by in vitro studies. Among factors which can affect neurotoxic outcomes, age is considered most relevant. Human and animal studies suggest that air pollution may cause developmental neurotoxicity, and may contribute to the etiology of neurodevelopmental disorders, including autism spectrum disorder. In addition, air pollution exposure has been associated with increased expression of markers of neurodegenerative disease pathologies, such as alpha-synuclein or beta-amyloid, and may thus contribute to the etiopathogenesis of neurodegenerative diseases, particularly Alzheimer’s disease and Parkinson’s disease.
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Cited by
Infection and Risk of Parkinson’s Disease
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Environmental Air Pollutants Affecting Skin Functions with Systemic Implications
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Association of improved air quality with lower dementia risk in older women
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Metadata
- Authors
- Costa, L. G., Cole, T. B., Dao, K., Chang, Y.-C., Coburn, J., & Garrick, J. M.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 210
- Pages
- 107523
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W3010038216
- Cited by
- 484
- References
- 359
- FWCI
- 19.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Costa, L. G., Cole, T. B., Dao, K., Chang, Y.-C., Coburn, J., & Garrick, J. M. (2020). Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders. Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2020.107523
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
