Signal transducer and activator of transcription 3 signaling in tumor immune evasion

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Garcia-Diaz, A., Shin, D. S., Moreno, B. H., Saco, J., Escuin-Ordinas, H., Rodriguez, G. A., Zaretsky, J. M., Sun, L., Hugo, W., Wang, X., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.031 · Cited by 1,942 · see citing works

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment

Yu, H., Kortylewski, M., & Pardoll, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1995 · Cited by 1,809 · see citing works

The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

Wang, P., Xue, Y., Han, Y., Li, L., Wu, C., Xu, S., Jiang, Z., Xu, J., Liu, Q., & Cao, X. (2014) · Science · doi:10.1126/science.1251456 · Cited by 1,106 · see citing works

lncRNAs and microRNAs with a role in cancer development

Liz, J., & Esteller, M. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.06.015 · Cited by 511 · see citing works

STAT3 Target Genes Relevant to Human Cancers

Carpenter, R., & Lo, H.-W. (2014) · Cancers · doi:10.3390/cancers6020897 · Cited by 511 · see citing works

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

Zhou, J., Li, X., Wu, X., Zhang, T., Zhu, Q., Wang, X., Wang, H., Wang, K., Lin, Y., & Wang, X. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0479 · Cited by 386 · see citing works

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

Ye, S., Li, Z.-L., Luo, D., Huang, B., Chen, Y.-S., Zhang, X.-S., Cui, J., Zeng, Y.-X., & Li, J. (2014) · Oncotarget · doi:10.18632/oncotarget.2118 · Cited by 346 · see citing works

The role of STAT3 in leading the crosstalk between human cancers and the immune system

Wang, Y., Shen, Y., Wang, S., Shen, Q., & Zhou, X. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.12.003 · Cited by 340 · see citing works

Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion

Jiang, Y., & Zhan, H. (2020) · Cancer Letters · doi:10.1016/j.canlet.2019.10.013 · Cited by 319 · see citing works

PD-L1 induced by IFN-γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer

Zhang, X., Zeng, Y., Qu, Q., Zhu, J., Liu, Z., Ning, W., Zeng, H., Zhang, N., Du, W., Chen, C., et al. (2017) · International Journal of Clinical Oncology · doi:10.1007/s10147-017-1161-7 · Cited by 316 · see citing works

Mechanisms of immune evasion in breast cancer

Bates, J. P., Derakhshandeh, R., Jones, L. P., & Webb, T. J. (2018) · BMC Cancer · doi:10.1186/s12885-018-4441-3 · Cited by 298 · see citing works

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

Gabrusiewicz, K., Li, X., Wei, J., Hashimoto, Y., Marisetty, A., Ott, M., Wang, F., Hawke, D., Yu, J., Healy, L. M., et al. (2017) · Oncoimmunology · doi:10.1080/2162402x.2017.1412909 · Cited by 291 · see citing works

Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells

Wu, A. A., Drake, V. E., Huang, H.-S., Chiu, S., & Zheng, L. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1016700 · Cited by 274 · see citing works

The role of hypoxia‐inducible factor 1 in tumor immune evasion

Li, Y., Wu, W., Wang, X., Fang, L., Adam, V., Nepovimová, E., Wu, Q., & Kuča, K. (2020) · Medicinal Research Reviews · doi:10.1002/med.21771 · Cited by 273 · see citing works

Immune Suppression in the Tumor Microenvironment

Gajewski, T. F., Meng, Y., & Harlin, H. (2006) · Journal of Immunotherapy · doi:10.1097/01.cji.0000199193.29048.56 · Cited by 261 · see citing works

Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion

Fang, W., Zhou, T., Shi, H., Yao, M., Zhang, D., Qian, H., Zeng, Q., Wang, Y., Jin, F., Chai, C., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01786-6 · Cited by 257 · see citing works

Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression

Fu, X.-L., Duan, W., Su, C.-Y., Mao, F.-Y., Lv, Y.-P., Teng, Y.-S., Yu, P.-W., Zhuang, Y., & Zhao, Y.-L. (2017) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-017-2052-5 · Cited by 242 · see citing works

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

Otvos, B., Silver, D. J., Mulkearns-Hubert, E. E., Alvarado, A. G., Turaga, S. M., Sørensen, M. D., Rayman, P. A., Flavahan, W. A., Hale, J. S., Stoltz, K., et al. (2016) · Stem Cells · doi:10.1002/stem.2393 · Cited by 240 · see citing works

Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway

Liu, C., Yao, Z., Wang, J., Zhang, W., Yang, Y., Zhang, Y., Qu, X., Zhu, Y., Zou, J., Peng, S., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0460-0 · Cited by 235 · see citing works

Can We Design a Nogo Receptor-Dependent Cellular Therapy to Target MS?

Kim, M. J., Kang, J. H., Theotokis, P., Grigoriadis, N., & Petratos, S. (2018) · Cells · doi:10.3390/cells8010001 · Cited by 228 · see citing works

Noncanonical NF-κB Activation Mediates STAT3-Stimulated IDO Upregulation in Myeloid-Derived Suppressor Cells in Breast Cancer

Yu, J., Wang, Y., Fang, Y., Zhang, P., Li, H., Zhao, H., Yan, C., Fan, Y. L., & Ren, X. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400833 · Cited by 219 · see citing works

Glioblastoma-Derived IL6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth

Lamano, J. B., Lamano, J. B., Li, Y. D., DiDomenico, J. D., Choy, W., Veliceasa, D., Oyon, D. E., Fakurnejad, S., Ampie, L., Kesavabhotla, K., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2402 · Cited by 209 · see citing works

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

Neo, S., Yang, Y., Record, J., Ma, R., Chen, X., Chen, Z., Tobin, N. P., Blake, E., Seitz, C., Thomas, R., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128895 · Cited by 205 · see citing works

Mechanisms of Hypoxia-Mediated Immune Escape in Cancer

Barsoum, I. B., Koti, M., Siemens, D. R., & Graham, C. H. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2598 · Cited by 202 · see citing works

Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1α RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

Niu, G., Briggs, J., Deng, J., Ma, Y., Lee, H., Kortylewski, M., Kujawski, M., Kay, H. D., Cress, W. D., Jove, R., et al. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2177 · Cited by 177 · see citing works

FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway

Li, P., Huang, T., Zou, Q., Liu, D., Wang, Y., Tan, X., Yao, W., & Qiu, H. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801199 · Cited by 174 · see citing works

Involvement of M2‐polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation

Takaishi, K., Komohara, Y., Tashiro, H., Ohtake, H., Nakagawa, T., Katabuchi, H., & Takeya, M. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01652.x · Cited by 170 · see citing works

The function of Stat3 in tumor cells and their microenvironment.

Groner, B., Lucks, P., & Borghouts, C. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.06.005 · Cited by 165 · see citing works

Hypoxia-/HIF-1α-Driven Factors of the Tumor Microenvironment Impeding Antitumor Immune Responses and Promoting Malignant Progression

Vaupel, P. W., & Multhoff, G. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-91287-5_27 · Cited by 161 · see citing works

M2 tumor‑associated macrophages promote tumor progression in non‑small‑cell lung cancer

Sumitomo, R., Hirai, T., Fujita, M., Murakami, H., Otake, Y., & Huang, C. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8068 · Cited by 161 · see citing works

STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer

Oweida, A. J., Darragh, L. B., Phan, A. V., Binder, D. C., Bhatia, S., Mueller, A. C., Court, B. V., Milner, D. C., Raben, D., Woessner, R. D., et al. (2019) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djz036 · Cited by 156 · see citing works

Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment

Dumas, A. A., Pomella, N., Rosser, G., Guglielmi, L., Vinel, C., Millner, T. O., Rees, J. H., Aley, N., Sheer, D., Wei, J., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103790 · Cited by 155 · see citing works

The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells

Wang, J., Veirman, K. D., Beule, N. D., Maes, K., Bruyne, E. D., Valckenborgh, E. V., Vanderkerken, K., & Menu, E. (2015) · Oncotarget · doi:10.18632/oncotarget.6083 · Cited by 154 · see citing works

Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels

Zhou, C., Wei, W.-F., Ma, J., Yang, Y., Liang, L.-J., Zhang, Y., Wang, Z., Chen, X., Huang, L., Wang, W., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.12.034 · Cited by 154 · see citing works

PD-L1 Expression Correlates With Tumor Infiltrating Lymphocytes And Response To Neoadjuvant Chemotherapy In Cervical Cancer

Meng, Y., Liang, H., Hu, J., Liu, S., Hao, X., Wong, M. S. K., Li, X., & Hu, L. (2018) · Journal of Cancer · doi:10.7150/jca.22532 · Cited by 151 · see citing works

Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

Carter, E. P., Fearon, A. E., & Grose, R. P. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.003 · Cited by 147 · see citing works

Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis

Sun, L., Wang, Q., Chen, B., Zhao, Y., Shen, B., Wang, H., Xu, J., Zhu, M., Zhao, X., Xu, C., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0988-9 · Cited by 147 · see citing works

STAT3: A Target to Enhance Antitumor Immune Response

Lee, H., Pal, S. K., Reckamp, K. L., Figlin, R. A., & Yu, H. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_51 · Cited by 134 · see citing works

STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment

Laudisi, F., Cherubini, F., Monteleone, G., & Stolfi, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061787 · Cited by 128 · see citing works

LncRNA NEAT1 sponges miR-214 to regulate M2 macrophage polarization by regulation of B7-H3 in multiple myeloma

Gao, Y., Peng, F., Li, W., Zhang, J., Wang, G., Jiang, D., & Chen, F. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.10.026 · Cited by 125 · see citing works

Correction: Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway

Liu, C., Yao, Z., Wang, J., Zhang, W., Yang, Y., Zhang, Y., Qu, X., Zhu, Y., Zou, J., Peng, S., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0506-3 · Cited by 122 · see citing works

HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape

Han, Q., Zhao, H., Yu, J., Yin, C., & Zhang, J. (2019) · Cells · doi:10.3390/cells8060558 · Cited by 119 · see citing works

STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis

Jones, L., Broz, M. L., Ranger, J. J., Ozcelik, J., Ahn, R., Zuo, D., Ursini‐Siegel, J., Hallett, M. T., Krummel, M. F., & Muller, W. J. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2770 · Cited by 117 · see citing works

The role of regulatory T-cells in glioma immunology

Ooi, Y. C., Tran, P., Ung, N. M., Thill, K., Trang, A., Fong, B., Nagasawa, D. T., Lim, M. K., & Yang, I. (2014) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2013.12.004 · Cited by 116 · see citing works

IL6/STAT3 Signaling Orchestrates Premetastatic Niche Formation and Immunosuppressive Traits in Lung

Jing, B., Wang, T., Sun, B., Xu, J., Xu, D., Liao, Y., Song, H., Guo, W., Li, K., Hu, M. S., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-2013 · Cited by 114 · see citing works

Targeting STAT3 in cancer and autoimmune diseases

Gharibi, T., Babaloo, Z., Hosseini, A., Abdollahpour‐Alitappeh, M., Hashemi, V., Marofi, F., Nejati‐Koshki, K., & Baradaran, B. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173107 · Cited by 104 · see citing works

S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3

Priceman, S. J., Shen, S., Wang, L., Deng, J., Yue, C., Kujawski, M., & Yu, H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.016 · Cited by 99 · see citing works

B-cell receptor–mediated NFATc1 activation induces IL-10/STAT3/PD-L1 signaling in diffuse large B-cell lymphoma

Li, L., Zhang, J., Chen, J., Xu-Monette, Z. Y., Miao, Y., Xiao, M., Young, K. H., Wang, S., Medeiros, L. J., Wang, M. L., et al. (2018) · Blood · doi:10.1182/blood-2018-03-841015 · Cited by 97 · see citing works

Stat3 as a Potential Target for Cancer Immunotherapy

Kortylewski, M., & Yu, H. (2007) · Journal of Immunotherapy · doi:10.1097/01.cji.0000211327.76266.65 · Cited by 93 · see citing works

Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?

Huang, Q., Zhong, Y., Dong, H., Zheng, Q., Shi, S., Zhu, K., Qu, X., Hu, W., Zhang, X., & Wang, Y. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111922 · Cited by 93 · see citing works

Hypoxia‑inducible factors in hepatocellular carcinoma (Review)

Guo, Y., Xiao, Z., Liu, Y., Gao, Y., Zhu, Q., Hu, L., Huang, D., & Xu, Q. (2019) · Oncology Reports · doi:10.3892/or.2019.7397 · Cited by 92 · see citing works

Dendritic cells with an increased PD-L1 by TGF-β induce T cell anergy for the cytotoxicity of hepatocellular carcinoma cells

Song, S., Yuan, P., Wu, H., Chen, J., Fu, J., Li, P., Lu, J., & Wei, W. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.02.027 · Cited by 84 · see citing works

LncRNA H19 promotes epithelial mesenchymal transition and metastasis of esophageal cancer via STAT3/EZH2 axis

Chen, M., Deng, J., Chen, C., Hu, W., Yuan, Y., & Xia, Z. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.05.011 · Cited by 84 · see citing works

Immune evasion mechanisms in acute myeloid leukemia: A focus on immune checkpoint pathways

Taghiloo, S., & Asgarian‐Omran, H. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103164 · Cited by 82 · see citing works

Inhibition of JAK2/STAT3 reduces tumor‐induced angiogenesis and myeloid‐derived suppressor cells in head and neck cancer

Liu, J., Deng, W., Chen, L., Li, Y., Wu, L., Ma, S., Zhang, W., Bu, L., & Sun, Z. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22767 · Cited by 82 · see citing works

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses

Wang, W., Yen, M., Liu, K., Hsu, P., Sytwu, H., Chen, P., Sudhir, P., Chen, C., Chen, C., Hk, S., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.07.013 · Cited by 80 · see citing works

The interplay between HIF-1α and noncoding RNAs in cancer

Peng, X., Gao, H., Xu, R., Wang, H., Mei, J., & Liu, C. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-1535-y · Cited by 77 · see citing works

Hypoxia Impairs NK Cell Cytotoxicity through SHP‐1‐Mediated Attenuation of STAT3 and ERK Signaling Pathways

Teng, R., Wang, Y., Lv, N., Zhang, D., Williamson, R. A., Lei, L., Chen, P., Li, L., Wang, B., Fu, J., et al. (2020) · Journal of Immunology Research · doi:10.1155/2020/4598476 · Cited by 77 · see citing works

Immunosuppressive CD14 + HLA-DR lo/neg monocytes are elevated in pancreatic cancer and “primed” by tumor-derived exosomes

Javeed, N., Gustafson, M. P., Dutta, S. K., Lin, Y., Bamlet, W. R., Oberg, A. L., Petersen, G. M., Chari, S. T., Dietz, A. B., & Mukhopadhyay, D. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1252013 · Cited by 76 · see citing works

Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment

Luo, Y., Yang, J., Yu, J., Liu, X., Yu, C., Hu, J., Shi, H., & Ma, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00048 · Cited by 74 · see citing works

Long non-coding RNASNHG17 promotes the progression of breast cancer by sponging miR-124-3p

Du, Y., Wei, N., Hong, J., & Pan, W. (2020) · Cancer Cell International · doi:10.1186/s12935-020-1129-y · Cited by 67 · see citing works

The Role of Long Non-coding RNAs in Immunotherapy Resistance

Zhou, Y., Zhu, Y., Xie, Y., & Ma, X. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01292 · Cited by 66 · see citing works

Hypoxia-induced autophagy

Noman, M. Z., Janji, B., Berchem, G., Mami‐Chouaib, F., & Chouaı̈b, S. (2012) · Autophagy · doi:10.4161/auto.19572 · Cited by 64 · see citing works

lncRNA H19 promotes viability and epithelial-mesenchymal transition of lung adenocarcinoma cells by targeting miR-29b-3p and modifying STAT3

Liu, L., Liu, L., & Si-jing, L. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4695 · Cited by 61 · see citing works

5-Hydroxytryptamine1a receptors on tumour cells induce immune evasion in lung adenocarcinoma patients with depression via autophagy/pSTAT3

Liu, Y., Zhang, H., Wang, Z., Pin, W., & Gong, W. (2019) · European Journal of Cancer · doi:10.1016/j.ejca.2019.03.017 · Cited by 61 · see citing works

Hypoxia-induced lncRNA RP11-390F4.3 promotes epithelial-mesenchymal transition (EMT) and metastasis through upregulating EMT regulators

Peng, P., Lai, J. C., Hsu, K., & Wu, K. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.014 · Cited by 61 · see citing works

Analysis of copy number alterations reveals the lncRNA ALAL-1 as a regulator of lung cancer immune evasion

Athie, A., Marchese, F. P., González, J., Lozano, T., Raimondi, I., Juvvuna, P. K., Abad, A., Marín-Béjar, O., Serizay, J., Martínez, D., et al. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201908078 · Cited by 59 · see citing works

Combined inhibition of JAK1,2/Stat3‑PD‑L1 signaling pathway suppresses the immune escape of castration‑resistant prostate cancer to NK cells in hypoxia

Xu, L., Ma, Q., Zhu, J., Li, J., Xue, B., Gao, J., Sun, C., Zang, Y., Zhou, Y., Yang, D., et al. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8905 · Cited by 52 · see citing works

PD-L1/PD-1 axis as a potent therapeutic target in breast cancer

Bastaki, S., Irandoust, M., Ahmadi, A., Hojjat‐Farsangi, M., Ambrose, P., Hallaj, S., Edalati, M., Ghalamfarsa, G., Azizi, G., Yousefi, M., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117437 · Cited by 50 · see citing works

STAT3 inhibition reduced PD‐L1 expression and enhanced antitumor immune responses

Jahangiri, A., Dadmanesh, M., & Ghorban, K. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29750 · Cited by 48 · see citing works

STAT3-Induced lncRNA SNHG17 Exerts Oncogenic Effects on Ovarian Cancer through Regulating CDK6

Pan, X., Guo, Z., Chen, Y., Zheng, S., Peng, M., Yang, Y., & Wang, Z. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.08.006 · Cited by 47 · see citing works

Targeting STAT3 phosphorylation by neem leaf glycoprotein prevents immune evasion exerted by supraglottic laryngeal tumor induced M2 macrophages

Goswami, K. K., Barik, S., Sarkar, M., Bhowmick, A. K., Biswas, J. K., Bose, A., & Baral, R. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.01.015 · Cited by 44 · see citing works

STAT3 Dysregulation in Mature T and NK Cell Lymphomas

Seffens, A., Herrera, A. M., Tegla, C., Buus, T. B., Hymes, K. B., Ødum, N., Geskin, L. J., & Koralov, S. B. (2019) · Cancers · doi:10.3390/cancers11111711 · Cited by 42 · see citing works

In papillary thyroid carcinoma, expression by immunohistochemistry of BRAF V600E, PD-L1, and PD-1 is closely related

Bai, Y., Guo, T., Huang, X., Wu, Q., Niu, D., Ji, X., Feng, Q. F., Li, Z., & Kakudo, K. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2357-6 · Cited by 42 · see citing works

A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 pathway in melanoma microenvironment

Liu, Y.-X., Bai, J., Li, T., Fu, X., Guo, H., Zhu, P., Chan, Y.-C., Chou, J., Yin, C., Li, J., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.020 · Cited by 42 · see citing works

Anti-PD-L1/PD-1 immune therapies in ovarian cancer: basic mechanism and future clinical application

Mandai, M., Hamanishi, J., Abiko, K., Matsumura, N., Baba, T., & Konishi, I. (2016) · International Journal of Clinical Oncology · doi:10.1007/s10147-016-0968-y · Cited by 40 · see citing works

Corrigendum to “Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways”

Teng, R., Wang, Y., Lv, N., Zhang, D., Williamson, R. A., Lei, L., Chen, P., Li, L., Wang, B., Fu, J., et al. (2021) · Journal of Immunology Research · doi:10.1155/2021/3625084 · Cited by 37 · see citing works

Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations

Wu, Q., Wu, W., França, T. C. C., Jacevic, V. M., Wang, X., & Kuča, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113307 · Cited by 36 · see citing works

VEGFR2 Promotes Metastasis and PD-L2 Expression of Human Osteosarcoma Cells by Activating the STAT3 and RhoA-ROCK-LIMK2 Pathways

Zheng, B., Zhou, C., Qu, G., Ren, C., Peng, Y., Guo, W., & Yue, B. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.543562 · Cited by 34 · see citing works

The Tumor Microenvironment: Part 1

Leibovici, J., Itzhaki, O., Huszar, M., & Sinai, J. (2011) · Immunotherapy · doi:10.2217/imt.11.111 · Cited by 33 · see citing works

HIF-1α induces immune escape of prostate cancer by regulating NCR1/NKp46 signaling through miR-224

Chen, C., Li, S.-X., Xiang, L., Mu, H., Wang, S.-B., & Yu, K.-Y. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.007 · Cited by 33 · see citing works

Role and mechanism of programmed death‑ligand�1 in hypoxia‑induced liver cancer immune escape (Review)

Wen, Q.-X., Han, T., Wang, Z., & Jiang, S. (2020) · Oncology Letters · doi:10.3892/ol.2020.11369 · Cited by 32 · see citing works

STAT3-induced upregulation of lncRNA SNHG17 predicts a poor prognosis of melanoma and promotes cell proliferation and metastasis through regulating PI3K-AKT pathway.

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Sunitinib inhibits PD-L1 expression in osteosarcoma by targeting STAT3 and remodels the immune system in tumor-bearing mice

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Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet

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LncRNA ZEB1-AS1 contributes to STAT3 activation by associating with IL-11 in B-lymphoblastic leukemia

Wang, Q., Du, X., Yang, M., Xiao, S., Cao, J., Song, J. H., & Wang, L. (2017) · Biotechnology Letters · doi:10.1007/s10529-017-2421-3 · Cited by 30 · see citing works

The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer

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Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling

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Long non-coding RNA THOR promotes ovarian Cancer cells progression via IL-6/STAT3 pathway

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Hyperprogressive disease with anti-PD-1 and anti-PD-L1

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Hypoxia-Inducible Factor-1α and Autoimmune Lupus, Arthritis

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Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models

Coulibaly, A., Bettendorf, A., Kostina, E., Figueiredo, A. S., Velásquez, S. Y., Bock, H.-G., Thiel, M., Lindner, H. A., & Barbarossa, M. V. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02401 · Cited by 22 · see citing works

Quercetin promotes the survival of granulocytic myeloid-derived suppressor cells via the ESR2/STAT3 signaling pathway

Ma, Z., Xia, Y., Hu, C., Yu, M., & Yi, H. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109922 · Cited by 21 · see citing works

STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma

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Supraglottic laryngeal tumor microenvironmental factors facilitate STAT3 dependent pro-tumorigenic switch in tumor associated macrophages to render utmost immune evasion

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Ectopic PD-L1 expression in JAK2 (V617F) myeloproliferative neoplasm patients is mediated via increased activation of STAT3 and STAT5

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The Important Role of STAT3 in Chronic Lymphocytic Leukaemia Biology

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Eat this, not that! How selective autophagy helps cancer cells survive

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Symbionts and metabolites

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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

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Stat3 Signaling Pathway: A Future Therapeutic Target for Bone-Related Diseases

Li, J., Yin, Z., Huang, B., Xu, K., & Su, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.897539 · Cited by 67 · see citing works

Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer

Jin, J., Wu, Y., Zhao, Z., Wu, Y., Zhou, Y.-D., Liu, S., Sun, Q., Yang, G., Lin, J., Nagle, D. G., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.160606 · Cited by 57 · see citing works

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

Fan, S., Lin, W., Huang, Y., Xia, J., Xu, J., Zhang, J., & Pi, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.829712 · Cited by 56 · see citing works

The Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance

Witalisz‐Siepracka, A., Klein, K., Moser, B., & Stoiber, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947568 · Cited by 53 · see citing works

Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells

Kim, N. Y., Mohan, C. D., Sethi, G., & Ahn, K. S. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30537 · Cited by 52 · see citing works

CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer

Chen, X., Liu, Y., Wang, Y., Wang, C., Chen, X., Xiong, Y., Liu, L., Yuan, X., Tang, H., Shu, C., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-4029 · Cited by 44 · see citing works

Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway

Long, D., Mao, C., Zhang, W., Zhu, Y., & Xu, Y. Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1538302 · Cited by 44 · see citing works

The immunosuppression pathway of tumor‐associated macrophages is controlled by heme oxygenase‐1 in glioblastoma patients

Magri, S., Musca, B., Pinton, L., Orecchini, E., Belladonna, M. L., Orabona, C., Bonaudo, C., Volpin, F., Ciccarino, P., Baro, V., et al. (2022) · International Journal of Cancer · doi:10.1002/ijc.34270 · Cited by 34 · see citing works

lncRNA MIAT targets miR‐411‐5p/STAT3/PD‐L1 axis mediating hepatocellular carcinoma immune response

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Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis

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UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling

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Targeting ferroptosis, pyroptosis and necroptosis for cancer immunotherapy in melanoma: mechanistic insights and clinical perspectives

Shan, Z., & Liu, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1629620 · Cited by 25 · see citing works

Deoxynivalenol hijacks the pathway of Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT-3) to drive caspase-3-mediated apoptosis in intestinal porcine epithelial cells

Zhang, Z., Fan, K., Meng, J., Nie, D., Zhao, Z., & Han, Z. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.161058 · Cited by 24 · see citing works

Alcohol reshapes a liver premetastatic niche for cancer by extra- and intrahepatic crosstalk-mediated immune evasion

Qiu, X., Zhou, J.-Q., Xu, H., Li, Y.-Y., Ma, S.-D., Qiao, H., Zeng, K., Wang, Q.-Q., Ouyang, J., Liu, Y.-H., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.07.012 · Cited by 25 · see citing works

N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding with KAT2B

Han, H., Zhu, W., Ting, L., Liu, C., & Zhai, H. (2022) · Cancer Science · doi:10.1111/cas.15498 · Cited by 21 · see citing works

Multi-omics analysis reveals interferon-stimulated gene OAS1 as a prognostic and immunological biomarker in pan-cancer

Yang, R., Du, Y., Zhang, M., Liu, Y., Feng, H., Liu, R., Yang, B., Xiao, J., He, P., & Niu, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1249731 · Cited by 19 · see citing works

Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP ‐1 expression, and the STAT3 pathway

Jung, Y. Y., Son, N. T., Mohan, C. D., Bastos, J. K., Luyen, N. D., Le, M. H., & Ahn, K. S. (2024) · IUBMB Life · doi:10.1002/iub.2827 · Cited by 19 · see citing works

Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NF-κB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus

Wen, Z., Zhang, Y., Feng, J., Aimulajiang, K., Aleem, M. T., Lu, M., Xu, L., Song, X., Li, X., & Yan, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1013159 · Cited by 18 · see citing works

CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3

You, A., Yang, H., Lai, C.-P., Lei, W. H., Yang, L., Lin, J.-L., Liu, S.-C., Ding, N., & Ye, F. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05767-3 · Cited by 18 · see citing works

Cancer-associated fibroblasts drive early pancreatic cancer cell invasion via the SOX4/MMP11 signalling axis

Ge, F., Zeng, C., Wang, J., Liu, X., Zheng, C., Zhang, H., Yang, L., Yang, B., Zhu, H., & He, Q. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166852 · Cited by 18 · see citing works

CAR-T lymphocyte-based cell therapies; mechanistic substantiation, applications and biosafety enhancement with suicide genes: new opportunities to melt side effects

Ercilla-Rodríguez, P., Sánchez‐Díez, M., Alegría‐Aravena, N., Quiroz‐Troncoso, J., Gavira-O’Neill, C. E., González‐Martos, R., & Ramírez‐Castillejo, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1333150 · Cited by 15 · see citing works

Viscum album Induces Apoptosis by Regulating STAT3 Signaling Pathway in Breast Cancer Cells

Park, Y.-R., Jee, W., Park, S.-M., Kim, S. W., Bae, H., Jung, J. H., Kim, H., Kim, S., Chung, J. S., & Jang, H.-J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511988 · Cited by 14 · see citing works

Dihydroartemisinin inhibits tumor progress via blocking ROR1-induced STAT3-activation in non-small cell lung cancer

Li, Y., Sun, H., Bai, C., Hu, Y., Tang, J., Zhang, Y., Chen, J., 钟占琼, He, Y., Hu, K., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112157 · Cited by 12 · see citing works

Dimethyl fumarate ameliorated pyroptosis in contrast-induced acute renal injury by regulating endoplasmic reticulum stress and JAK2-STAT3 pathway

An, X., Yin, M., Shen, Y., Guo, X.-Y., Xu, Y.-H., Cheng, D., & Gui, D.-K. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2504633 · Cited by 8 · see citing works

Deoxynivalenol upregulates hypoxia-inducible factor-1α to promote an “immune evasion” process by activating STAT3 signaling

Zhang, L., Wang, X., Nepovimová, E., Wu, Q., Wu, W., & Kuča, K. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113975 · Cited by 12 · see citing works

High Expression Level of BRD4 Is Associated with a Poor Prognosis and Immune Infiltration in Esophageal Squamous Cell Carcinoma

Li, L., Gao, L., Zhou, H., Shi, C., Zhang, X., Zhang, D., & Liu, H. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-07907-3 · Cited by 11 · see citing works

Emerging Therapeutic Targets and Drug Resistance Mechanisms in Immunotherapy of Hematological Malignancies

Olejarz, W., & Basak, G. W. (2023) · Cancers · doi:10.3390/cancers15245765 · Cited by 11 · see citing works

Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer

Dmello, R. S., Palmieri, M., Thilakasiri, P. S., Doughty, L., Nero, T. L., Poh, A. R., To, S. Q., Lee, E. F., Fairlie, W. D., Mielke, L. A., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06631-8 · Cited by 11 · see citing works

Advancements in a novel model of autophagy and immune network regulation in radioresistance of cancer stem cells

Li, L., Wang, X., Jiang, M., Li, L., Wang, D., & Li, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117420 · Cited by 10 · see citing works

LncRNA ALMS1 ‐ IT1 modulates ferroptosis and immune evasion in colorectal cancer through activating STAT3

Wu, Z., Zou, J., Xie, H., Wang, J., Huang, Y., Liu, F., & Xing, C. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70103 · Cited by 9 · see citing works

Przewaquinone A, as a natural STAT3 inhibitor, suppresses the growth of melanoma cells and induces autophagy

Jiang, X., Liu, B., Li, J., Lin, Y.-F., Zhu, P., Zhang, Z., Wang, Y., Deng, B., Zhang, J., & Yung, K. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156810 · Cited by 9 · see citing works

Role of microRNAs in immunoregulatory functions of epithelial cells

Jafari, N., & Abediankenari, S. (2024) · BMC Immunology · doi:10.1186/s12865-024-00675-3 · Cited by 12 · see citing works

Characterization of the Immune Cell Infiltration Landscape Uncovers Prognostic and Immunogenic Characteristics in Lung Adenocarcinoma

Wang, X., Xu, Z., Liu, Z., Lin, W., Cao, Z., Feng, X., Gao, Y., & He, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.902577 · Cited by 9 · see citing works

Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions

Li, J., Yang, R., Dong, F., Qiu, Q., Jiang, Z., Ren, H., Zhang, C., Liu, G., Lovell, J. F., & Zhang, Y. (2024) · ACS Nano · doi:10.1021/acsnano.3c12375 · Cited by 7 · see citing works

Analysis of lactate metabolism-related genes and their association with immune infiltration in septic shock via bioinformatics method

Jiang, H., Ren, Y., Yu, J., Hu, S. C., & Zhang, J. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1223243 · Cited by 7 · see citing works

Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's Disease

Geng, Y., Wang, R., Dong, M., Qian, Y.-L., Wang, X., Xia, W.-W., Shen, Y. H., & Zhang, K. (2025) · Inflammation · doi:10.1007/s10753-025-02306-4 · Cited by 7 · see citing works

Brain-targeted polymersomes mediating RNAi of STAT3 sensitize glioblastoma to temozolomide and immunotherapy

Xia, M., Zhao, S., Sun, Z., Shi, Y., Lin, W., Zhong, Z., & Meng, F. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.137751 · Cited by 5 · see citing works

Pyroptosis and cancer: Linking inflammatory cell death to tumorigenesis and therapy

Pathania, A., Pandey, R. K., & Mehrotra, S. (2025) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2025.06.021 · Cited by 5 · see citing works

Isodeoxyelephantopin Promotes Cell Death in Triple‐Negative Breast Cancer by Blocking STAT3 Phosphorylation and Enhancing the Effectiveness of Paclitaxel

Lin, D., Wang, H., Shi-xi, W., & Chen, H. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70737 · Cited by 5 · see citing works

Targeting autophagy to enhance cancer immunotherapy: emerging mechanisms and strategies

Almutairi, J. A. (2025) · Medical Oncology · doi:10.1007/s12032-025-03081-w · Cited by 5 · see citing works

Key Role of STAT3 in Osteoarthritis: From Pathogenic Mechanisms to Targeted Therapy

Zhao, S., Xu, H., Chen, J., Zhang, H., Dong, S., Yang, Y., & Li, Z. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s558209 · Cited by 5 · see citing works

Inhibition of the STAT3-EPHX2 axis promotes regression of ulcerative colitis by treatment with novel porphyrin derivative

Xu, B., Wen, Y., Xu, J. Y., Rong, Y., Wang, X., & Liu, T. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107579 · Cited by 5 · see citing works

Socs1-knockout in skin-resident CD4+ T cells in a protracted contact-allergic reaction results in an autonomous skin inflammation with features of early-stage mycosis fungoides

Luo, Y., Vermeer, M. H., de Haan, S., Kinderman, P., de Gruijl, F. R., van Hall, T., & Tensen, C. P. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101535 · Cited by 5 · see citing works

p‐Cymene Targets Multiple Oncogenic Pathways in Hepatocellular Carcinoma: Insights From Network Pharmacology and In Vitro Studies

Anwar, N., Malik, M. N. H., Atif, M., Alanzi, A. R., Alharbi, H. A., Younis, W., Abbas, M., & Solre, G. F. B. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.71108 · Cited by 4 · see citing works

TMP: A dual modulator of apoptosis and autophagy via SHP-1 regulation in hepatocellular carcinoma

Jung, Y. Y., Hong, Y., Nam, D., Deivasigamani, A., Narula, A. S., Chinnathambi, A., Namjoshi, O. A., Blough, B. E., Alharbi, S. A., Hui, K. M., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123316 · Cited by 4 · see citing works

AICAR-loaded and panitumumab conjugated nanoparticles downregulate the expression of PD-L1 and enhance antitumor responses against ovarian cancer through the AMPK/STAT3 axis

Baniya, M. K., Duwa, R., Shrestha, P., Chang, J., Chun, K., & Yook, S. (2024) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-024-00702-w · Cited by 4 · see citing works

Exploring the novel role and mechanistic insights of skeletal muscle relaxant cyclobenzaprine hydrochloride in esophageal squamous cell carcinoma treatment

Liu, X., Cheng, J., Tang, M., Liao, C., Yang, Y., Luo, M., Xu, L., Zhong, X., Ma, Q., & Guo, X. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107051 · Cited by 4 · see citing works

Pan-cancer analysis of STAT3 indicates its potential prognostic value and correlation with immune cell infiltration in prostate cancer

Tuo, Z., Zhang, H., He, K., Jiang, Z., Jiang, C., Chen, X., & Yuan, H. (2024) · Discover Oncology · doi:10.1007/s12672-024-01527-7 · Cited by 3 · see citing works

Genome-wide identification of STATs and analysis of their role in sex determination in Pacific oysters (Crassostrea gigas)

Ye, J., Zeng, J., Zheng, H., Zhang, C., Zhang, H., & Zheng, H. (2023) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2023.110933 · Cited by 3 · see citing works

Virtual Screening-Guided Discovery of Small-Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids

Kaur, B., Denzinger, K., Zhang, L., García-Vázquez, N., Wolber, G., & Gabr, M. T. (2025) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5c00550 · Cited by 2 · see citing works

Expanding the therapeutic horizon in inflammatory bowel disease: The rise of non-cytokine compounds

Prado, Á. D., García-Alonso, F. J., Arribas‐Rodríguez, E., Barrio, J., Gisbert, J. P., & Bernardo, D. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119401 · Cited by 2 · see citing works

JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention

Zhang, X., Li, P., Ma, F., Wang, T., Chu, Q., Wei, S., Xue, C., Wang, Z., & Lu, J. J. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02692-9 · Cited by 3 · see citing works

VISTA expressed on tumor cells is regulated by m6A and influences immune microenvironment through STAT3/CCL22 in NSCLC

Xu, H., Shen, K., Jiang, B., Xu, Q., Li, B., Ke, Z., Cheng, Q., Zhu, S., Wang, D., Song, Y., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06818-3 · Cited by 2 · see citing works

JSI‐124 inhibits cell proliferation and tumor growth by inducing autophagy and apoptosis in murine malignant mesothelioma

Zhang, C., Sun, Q., Zhao, J., Jiang, N., Hao, Y., Luo, J., Karim, S., Wu, L., de Perrot, M. E., Peng, C., et al. (2023) · Molecular Carcinogenesis · doi:10.1002/mc.23623 · Cited by 1 · see citing works

Protective Role of Erzhi Pills in H2O2-Induced Oxidative Stress, Inflammation, and Angiogenesis in ARPE-19 Cells

Ding, Y., Dong, Y., & Wei, W. (2025) · Biochemical Genetics · doi:10.1007/s10528-025-11214-z · Cited by 1 · see citing works

High MCM10 expression mediates TMZ resistance and promotes the progression of glioma

Tian, Q., Bao, Z., Zhao, Y., & Zhang, Q. (2025) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-025-04807-3 · Cited by 1 · see citing works

Hypoxia Alleviation-Potentiated Chemotherapy Enhances Anti-PD-L1 Treatment for Triple-Negative Breast Cancer via Improving Tumor Immunogenicity and Inhibiting STAT3 Activation

Feng, X., Deng, L., Gao, C., Yang, Z., Dong, H., Xie, S., Yu, C., Zhu, L., Zhang, M., Zhang, H., et al. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c21790 · Cited by 1 · see citing works

Astragaloside IV-PESV Repressed T Cell Immunosuppression by Inhibiting PD-L1 Expression in Prostate Cancer through STAT3 Pathway

You, X., Qiu, J., Li, Q., Zhang, Q., Sheng, W., Fu, W., & Cao, Y. (2023) · Journal of Food Biochemistry · doi:10.1155/2023/8884430

Breast cancer: JAK/STAT signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives

Altaf, I., Jan, A., Ahmad, S. N., Mir, A. W., Thakur, N., & Mir, M. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-23908-3.00001-0

Thermo-responsive astaxanthin-polymeric nanocarriers targeting STAT3-RIPK1 mediated PANoptosome formation for neuroprotection in retinal injury

Rong, R., Liu, J., Liang, G., Liu, Y., & Xia, X. (2026) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-026-01800-z

STAT3 Inhibitor Suppresses CCL2-dependent Recruitment and M2 Polarization of Tumor-associated Macrophages to Enhance Antitumor Immunity in Ovarian Cancer

Liu, Y., Zhang, Y., Nie, J., Wang, J., Hao, X., & Zhao, L. (2026) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-026-05721-x

Co-stimulatory signal deficiency impairs cytotoxic T lymphocyte function in tumor immune evasion: molecular mechanisms and therapeutic implications

Ma, J., Chen, J., Miao, T., Li, Y., Li, Y., Zhao, L., & Tian, H. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08711-z

Breaking adaptive oncogenic resistance in glioblastoma via targeting the EGFR–STAT3 axis

Ahmad, N., & Ullah, A. (2026) · Medical Oncology · doi:10.1007/s12032-026-03459-4

The role of immune aging in rheumatoid arthritis and its clinical and therapeutic significance

Wei, Y., Qi, W., Li, P., Wang, T., Wang, Z., Liu, H., Zhang, Y., 田杰祥, & Wang, G. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117531

Astragaloside IV and tumor microenvironmental barriers: immune mechanisms, evidence hierarchy, and implications for checkpoint blockade

Wang, Y., Liu, M., & Zhong, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1991297

Molecular mechanisms and targeted therapeutic strategies of TIGAR in regulating energy metabolism to promote tumor proliferation in breast cancer

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