In vivo antitumor and immunomodulation activities of different molecular weight lambda-carrageenans from Chondrus ocellatus
Abstract
lambda-Carrageenan is a sulfated galactan isolated from some red algae and have been reported to have many kinds of biological activities. lambda-Carrageenan from Chondrus ocellatus, an important economic alga in China and many other parts of the world, was degraded by microwave, and obtained five products that have different molecular weight: 650, 240, 140, 15, 9.3 kDa. Analytical results confirmed that microwave degradation might not change the chemical components and structure of polysaccharides under certain condition. In this study, tumor-inhibiting activities, weight of immune organ, nature killer cells activity, lymphocyte proliferation ratio and pathological slice of spleen and tumor cells from the control group and lambda-carrageenan-treated mice of transplanted S180 and H22 tumor were investigated. The results indicated that the five lambda-carrageenan samples all showed antitumor and immunomodulation activities in different degree. Molecular weight of polysaccharides had notable effect on the activities. In addition, their antitumor and immunomodulation have some relevance and the five lambda-carrageenans probably inhibited tumor by means of activating the immunocompetence of the body. Among all the experiment results, samples with the highest activities are PC4 and PC5 whose molecular weight are 15 and 9.3 kDa.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Products from microwave hydrolysis do not undergo structural changes and have enhanced immunomodulatory and anticancer capacities compared to the original substrate.
“The obtained products do not undergo structural changes and have a surprisingly enhanced immunomodulatory and anticancer capacities with regard to the original substrate.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [131]
Higher solubility of lower molecular weight products was remarked as a possible explanation for the enhanced capacities.
“The higher solubility of the products (with lower molecular weight) was remarked as a possible explanation for such observations [131].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [131]
Microwaves give rise to glucidic compounds of low molecular weight (≈12 kDa) from natural polysaccharides extracted from algae.
“The physical technique of microwaves also gives rise to glucidic compounds of low molecular weight (≈12 kDa) from natural polysaccharides extracted from algae.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [131]
The citation lists haven’t been fetched yet
References 23 · Cited by 339
- Authors
- Zhou, G.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zhou, G
- ORCID
- Zhou, G
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 50
- Issue
- 1
- Pages
- 47-53
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2033837674
- Cited by
- 339
- References
- 23
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 19 · 2023: 20 · 2022: 20 · 2021: 19 · 2020: 30 · 2019: 20 · 2018: 17 · 2017: 19 · 2016: 20 · 2015: 13 · 2014: 18 · 2013: 13 · 2012: 16
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Keywords
- lambda-carrageenan, Chondrus ocellatus, molecular weight, anticancer activity, immunomodulation, natural killer cells, lymphocyte proliferation, spleen, S180 tumor, H22 hepatocellular carcinoma, sulfated galactans, polysaccharides, red algae
- MeSH terms
- Animals, Antineoplastic Agents, Carrageenan, Immunologic Factors, Killer Cells, Natural, Lymphocytes, Mice, Inbred ICR, Microwaves, Molecular Weight, Neoplasm Transplantation, Organ Size, Spleen, Tumor Cells, Cultured, Chondrus, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
