Natural products as a potential modulator of microglial polarization in neurodegenerative diseases

α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity

Hu, Z., Wang, W., Jing, L., & Jiang, C. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0264-9 · Cited by 51

18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination

Zhou, J., Cai, W., Jin, M., Xu, J., Wang, Y., Xiao, Y., Li, H., Wang, B., Zhang, Y., Han, J., et al. (2015) · Scientific Reports · doi:10.1038/srep13713 · Cited by 50

Andrographolide attenuates microglia-mediated Aβ neurotoxicity partially through inhibiting NF-κB and JNK MAPK signaling pathway

Yang, R., Liu, S., Zhou, J., Bu, S.-H., & Zhang, J. (2017) · Immunopharmacology and immunotoxicology · doi:10.1080/08923973.2017.1344989 · Cited by 50

SIRT1 counteracted the activation of STAT3 and NF-κB to repress the gastric cancer growth.

Lu, J., Zhang, L., Chen, X., Lu, Q., Yang, Y., Liu, J., & Ma, X. (2014) · PubMed Central · Cited by 49

Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease

Zhou, T., Zu, G., Wang, X., Zhang, X., Li, S., Liang, Z., & Zhao, J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.10.032 · Cited by 49

Taurine protects noradrenergic locus coeruleus neurons in a mouse Parkinson’s disease model by inhibiting microglial M1 polarization

Hou, L., Che, Y., Sun, F., & Wang, Q. (2018) · Amino Acids · doi:10.1007/s00726-018-2547-1 · Cited by 49

Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson’s Disease Model

Sharma, N., & Nehru, B. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9267-2 · Cited by 48

Modulation of Inducible Nitric Oxide Synthase Expression in LPS-Stimulated BV-2 Microglia by Prenylated Chalcones from Cullen corylifolium (L.) Medik. through Inhibition of I-κBα Degradation

Kim, D., Li, H., Han, Y. E., Jeong, J. H., Lee, H. J., & Ryu, J. (2018) · Molecules · doi:10.3390/molecules23010109 · Cited by 48

Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis

Shibata, N., Yamamoto, T., Hiroi, A., Omi, Y., Kato, Y., & Kobayashi, M. (2009) · Neuropathology · doi:10.1111/j.1440-1789.2009.01078.x · Cited by 47

Aromatic‐Turmerone Attenuates LPS‐Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4‐Dependent Signaling Pathway

Chen, M., Chang, Y., Huang, S., Xiao, L., Zhou, W., Zhang, L., Li, C., Zhou, R., Tang, J., Lin, L., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700281 · Cited by 47

Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice

Jiang, Y., Li, Z., Ma, H., Cao, X., Liu, F., Tian, A., Sun, X.-J., Li, X., & Wang, J. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489155 · Cited by 47

Taurine chloramine and taurine bromamine induce heme oxygenase-1 in resting and LPS-stimulated J774.2 macrophages

Olszanecki, R., & Marcinkiewicz, J. (2004) · Amino Acids · doi:10.1007/s00726-004-0097-1 · Cited by 46

Resveratrol Attenuates Microglial Activation via SIRT1‐SOCS1 Pathway

Zhang, S., Gao, L., Liu, X., Lu, T., Xie, C., & Jia, J. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/8791832 · Cited by 46

Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in Aβ25–35/IFN-γ–Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-κB, and Mitogen-Activated Protein Kinase Signaling Pathways

Qi, Y. A., Zou, L., Wang, L., Jin, G., Pan, J., Chi, T., & Ji, X. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13031fp · Cited by 45

Aromatic-turmerone’s anti-inflammatory effects in microglial cells are mediated by protein kinase A and heme oxygenase-1 signaling

Park, S. Y., Kim, Y. H., Kim, Y., & Lee, S.-J. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.06.020 · Cited by 45

Oral Treatment with the NADPH Oxidase Antagonist Apocynin Mitigates Clinical and Pathological Features of Parkinsonism in the MPTP marmoset Model

Philippens, I. H. C. H. M., Wubben, J. A. M., Finsen, B. R., & Hart, B. A. ‘. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9450-z · Cited by 44

Caffeic acid phenethyl ester extends survival of a mouse model of amyotrophic lateral sclerosis

Fontanilla, C. V., Wei, X., Zhao, L., Johnstone, B. H., Pascuzzi, R. M., Farlow, M. R., & Du, Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.025 · Cited by 44

Ginsenoside Re Attenuates Neuroinflammation in a Symptomatic ALS Animal Model

Cai, M., & Yang, E. J. (2016) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x16500233 · Cited by 44

Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway

Gu, S. M., Lee, H. P., Ham, Y. W., Son, D. J., Kim, H. Y., Oh, K. W., Han, S., Yun, J., & Hong, J. T. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8495-9 · Cited by 44

Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis

Yang, X., Yan, J., & Feng, J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.12.014 · Cited by 43

3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis.

Kuo, P.-C., Brown, D. A., Scofield, B., Yu, I.-C., Chang, F.-L. F., Wang, P., & Yen, J. (2016) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2016.03.015 · Cited by 43

NRF2/HO-1 activation via ERK pathway involved in the anti-neuroinflammatory effect of Astragaloside IV in LPS induced microglial cells

Li, C., Yang, F., Liu, F., et al. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.12.039 · Cited by 43

4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase

Lee, Y. K., Choi, I. S., Ban, J. O., Lee, H. J., Lee, U. S., Han, S., Jung, J., Kim, Y. H., Kim, K. H., Oh, K., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.04.002 · Cited by 41

Extracts of Actinidia arguta stems inhibited LPS-induced inflammatory responses through nuclear factor–κB pathway in Raw 264.7 cells

Kim, H.-Y., Hwang, K. W., & Park, S. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.08.019 · Cited by 41

Myricitrin Ameliorates 6-Hydroxydopamine-Induced Dopaminergic Neuronal Loss in the Substantia Nigra of Mouse Brain

Kim, H. D., Jeong, K. H., Jung, U. J., & Kim, S. R. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2015.3581 · Cited by 41

Triptolide Rescues Spatial Memory Deficits and Amyloid-? Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice

Cui, Y., Wang, Q., Zhang, D., et al. (2016) · Current Alzheimer Research · doi:10.2174/156720501303160217122803 · Cited by 41

Anti-Cancer Phytometabolites Targeting Cancer Stem Cells

Torquato, H. F. V., Goettert, M. I., Justo, G. Z., & Paredes‐Gamero, E. J. (2017) · Current Genomics · doi:10.2174/1389202917666160803162309 · Cited by 41

Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis

Li, X., Li, Z., Han, J., Zhang, F., Liu, S., Zhu, L. D., Wang, Z., Zhang, G., & Zhang, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01807 · Cited by 41

Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice

Go, J., Park, T., Han, G., Park, H.-Y., Ryu, Y., Kim, Y., Hwang, J. S., Choi, D., Noh, J., Hwang, D. Y., et al. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3782 · Cited by 41

Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid

Eufemi, M., Cocchiola, R., Romaniello, D., Correani, V., Di Francesco, L., Fabrizi, C., Maras, B., & Schininà, M. E. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.01.007 · Cited by 39

Myricetin prevents dopaminergic neurons from undergoing neuroinflammation-mediated degeneration in a lipopolysaccharide-induced Parkinson’s disease model

Huang, B., Liu, J., Ma, D., Chen, G., Wang, W., & Fu, S. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.018 · Cited by 36

4-O-Methylhonokiol Prevents Memory Impairment in the Tg2576 Transgenic Mice Model of Alzheimer's Disease Via Regulation of β-Secretase Activity

Lee, Y., Choi, D., Lee, Y. K., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111835 · Cited by 35

Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells

Konwinski, R. R., Haddad, R., Chun, J. A., Klenow, S., Larson, S. C., Haab, B. B., & Furge, L. L. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2004.06.006 · Cited by 35

Tenuigenin inhibits LPS-induced inflammatory responses in microglia via activating the Nrf2-mediated HO-1 signaling pathway

Wang, X., Li, M., Cao, Y., Wang, J., Zhang, H., Zhou, X., Li, Q., & Wang, L. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.004 · Cited by 35

Esculentoside A exerts anti-inflammatory activity in microglial cells

Yang, H., Chen, Y., Yu, L., & Xu, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.014 · Cited by 34

Esculentoside A suppresses Aβ1–42-induced neuroinflammation by down-regulating MAPKs pathwaysin vivo

Yang, H., Wang, S., Yu, L., Zhu, X., & Xu, Y. (2015) · Neurological Research · doi:10.1179/1743132815y.0000000066 · Cited by 33

Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model

Nie, J., Zhou, M., Lu, C. B., Hu, X., Wan, B., Yang, B., & Li, Y. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.03.021 · Cited by 32

L-3-n-Butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and upregulating Heme oxygenase-1 in lipopolysaccharide-treated mice

Zhao, C., Lei, H., Zhang, Y., Lin, L., Xu, S., Cai, J., Li, P., Wang, L., Wang, X., & Peng, Y. (2015) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2015.1099524 · Cited by 32

Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease

Go, J., Ha, T. K. Q., Seo, J. Y., Park, T., Ryu, Y., Park, H., Noh, J., Kim, Y., Hwang, J. H., Choi, D., et al. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.02.002 · Cited by 32

Macelignan Attenuates Activations of Mitogen-Activated Protein Kinases and Nuclear Factor kappa B Induced by Lipopolysaccharide in Microglial Cells

Ma, J., Hwang, Y. K., Cho, W.-H., Han, S., Hwang, J. K., & Han, J. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1085 · Cited by 31

Xanthoceraside attenuates amyloid β peptide 1-42 -induced memory impairments by reducing neuroinflammatory responses in mice

Qi, Y. A., Ji, X., Chi, T., Liu, P., Jin, G., Xu, Q., Jiao, Q., Wang, L.-H., & Zou, L. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.11.045 · Cited by 30

Pioglitazone use and Parkinson’s disease: a retrospective cohort study in Taiwan

Wu, H.-F., Kao, L., Shih, J., Kao, H., Chou, Y., Li, I., & Kao, S. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-023302 · Cited by 30

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

Jones, R. S., Minogue, A. M., Fitzpatrick, O. M., & Lynch, M. A. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.018 · Cited by 28

Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice

Zhu, L., Chi, T., Zhao, X., Yang, L., Song, S., Lu, Q., Ji, X., Liu, P., Wang, L., & Zou, L. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0561-9 · Cited by 26

Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis.

Zhang, M.-L., Zhang, X.-J., Kang, J.-S., Zhang, H.-J., Chen, X.-L., Liu, N., Liu, S., Ma, W.-D., Zhang, G.-X., & Zhu, L. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.005 · Cited by 25

GOAL: multicenter, open-label, post-marketing study of flavocoxid, a novel dual pathway inhibitor anti-inflammatory agent of botanical origin

Pillai, L., Burnett, B. P., Levy, R. M., et al. (2010) · Current Medical Research and Opinion · doi:10.1185/03007991003694522 · Cited by 24

A natural compound macelignan protects midbrain dopaminergic neurons from inflammatory degeneration via microglial arginase-1 expression

Kiyofuji, K., Kurauchi, Y., Hisatsune, A., et al. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.021 · Cited by 24

Elucidation of Relevant Neuroinflammation Mechanisms Using Gene Expression Profiling in Patients with Amyotrophic Lateral Sclerosis

Won, Y. H., Lee, M.-Y., Choi, Y., Ha, Y., Kim, S., ‍Kim, D. Y., Kim, M., Yu, J. H., Seo, J. H., Kim, M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165290 · Cited by 24

Matrine ameliorates experimental autoimmune encephalomyelitis by modulating chemokines and their receptors

Kan, Q., Pan, Q.-X., Zhang, X., et al. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.06.008 · Cited by 21

Oral administration of green tea epigallocatechin-3-gallate (EGCG) reduces amyloid beta deposition in transgenic mouse model of Alzheimer's disease

Li, Q., Gordon, M. N., Tan, J., & Morgan, D. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.02.062 · Cited by 21

Esculentoside A inhibits LPS-induced BV2 microglia activation through activating PPAR-γ

Li-hua, D., Li, Y., Shi-ji, W., Guang, W., Lu-lu, S., Xue-feng, P., & Pengda, S. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.07.029 · Cited by 21

Neuroprotective effect of heat shock protein 60 on matrine-suppressed microglial activation

Zhang, R., Li, Y., Hou, X., Miao, Z., & Wang, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4691 · Cited by 20

Pioglitazone is superior to quetiapine, clozapine and tamoxifen at alleviating experimental autoimmune encephalomyelitis in mice

Chedrawe, M. A. J., Holman, S. P., Lamport, A.-C., Akay, T., & Robertson, G. S. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.06.001 · Cited by 20

Reprint of: Microglial toll-like receptors and Alzheimer’s disease

Su, F., Bai, F., Zhou, H., & Zhang, Z. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.05.016 · Cited by 19

Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol

Jung, Y., Lee, Y., Choi, D., & Hong, J. T. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.030 · Cited by 18

Taurine Chloramine Suppresses LPS-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglial Cells

Lee, D., Kwon, K. H., & Cheong, S. H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1079-2_12 · Cited by 18

Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation

Lu, L.-L., Zhang, X.-P., Tong, H., Zhang, W.-L., Xu, P.-Y., & Qu, S.-G. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00789 · Cited by 17

Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

Qin, D.-P., Feng, X., Zhang, W., et al. (2017) · RSC Advances · doi:10.1039/c6ra27786a · Cited by 16

Synthetic Triterpenoid CDDO Derivatives Modulate Cytoprotective or Immunological Properties in Astrocytes, Neurons, and Microglia

Graber, D. J., Park, P. J., Hickey, W. F., & Harris, B. T. (2010) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-010-9240-9 · Cited by 15

Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis

Zhao, X., Zhang, X., Lv, Y., Xu, Y., Li, M., Qingxia, P., Chu, Y., Liu, N., Zhang, G., & Zhu, L. D. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.08.007 · Cited by 15

Tanshinone IIA Rescued the Impairments of Primary Hippocampal Neurons Induced by BV2 Microglial Over-Activation

Wang, Y., Yang, L. C., & Yang, D. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1624-z · Cited by 8

The multicentric randomized study of dl-3-butylphthalide in the treatment of acute moderate ischemic stroke

Liying, C. (2005) · Chinese Journal of Cenebrovascular Diseases · Cited by 8

Untitled work

(1999) · doi:10.1002/(sici)1521-3773(19990301)38:5

Curcumin Inhibits LPS-Induced Neuroinflammation by Promoting Microglial M2 Polarization via TREM2/TLR4/NF-Κb Pathways in BV2 Cells

Zhang, J., Zheng, Y., Luo, Y., Du, Y., Zhang, X., & Fu, J. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.09.020 · Cited by 464

Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies

Henríquez, G., Gomez, A., Guerrero, E., & Narayan, M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00381 · Cited by 83

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73

Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease

Dong, H., Zhang, X., Duan, Y., He, Y., Zhao, J., Wang, Z., Wang, J., Li, Q., Fan, G., Liu, Z., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03070-2 · Cited by 49

Whole-plant foods and their macromolecules: untapped approaches to modulate neuroinflammation in Alzheimer’s disease

Huang, R., Zhu, Z., Wu, Q., Bekhit, A. E.-D. A., Wu, S., Chen, M., Wang, J., & Ding, Y. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1975093 · Cited by 23

ФОРМИРОВAНИЕ ГОТОВНОСТИ БУДУЩИХ ПЕДAГОГОВ К ОРГAНИЗAЦИИ РAБОТЫ ПО РAЗВИТИЮ ВAЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ ШКОЛЬНИКОВ

БАЗАРБАЕВА, Ә. А., Майгельдиева, Ш. М., & ЖҮНДІБАЕВА, Т. Н. (2023) · Pedagogy and Psychology · doi:10.51889/2077-6861.2023.1.30.016

Коммуникaтивно- прaгмaтический aнaлиз дипломaтических бумaг (нa основе вербaльных нот)

Кaмирдиновa, Н., & Кaлиевa, Ш. С. (2018) · DOAJ (DOAJ: Directory of Open Access Journals)

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

A GEOMETRIC MEAN IN THE FURUTA INEQUALITY

Fujii, M., & Nakamoto, R. (2002) · Scientiae mathematicae Japonicae · Cited by 15