Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies
Abstract
One of the main features of neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease is the amyloidogenic behavior of disease-specific proteins including amyloid β, tau, α-synuclein, and mutant Huntingtin which participate in the formation, accumulation, and deposition of toxic misfolded aggregates. Consequently, these proteins not only associated with the progress of their respective neurodegenerative pathologies but also qualify as disease-specific biomarkers. The aim of using natural polyphenols is to target amyloid-dependent proteopathies by decreasing free radical damage and inhibiting and dissolving amyloid fibrils. We explore the effectiveness of the polyphenols epigallocatechin-3-gallate, oleuropein aglycone, and quercetin on their ability to inhibit aggregation of amyloid β, tau, and α-synuclein and mitigate other pathological features for Alzheimer’s disease and Parkinson’s disease. The analysis was carried from in vitro and cell line studies to animal models and clinical trials. This Review describes the use of phytochemical compounds as prophylactic agents for Alzheimer’s disease, Parkinson’s disease, and other proteopathies.
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Natural inhibitors interact directly with Aβ peptide through covalent or non-covalent bindings.
“These actions are underlain by the direct interaction of the compounds with the Aβ peptide through covalent or non-covalent bindings (Henriquez et al., 2020; Ma et al., 2020)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Henriquez et al., 2020
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Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works
Lin, X., Liu, W., Dong, X., & Sun, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.11.063 · Cited by 44 · see citing works
- Authors
- Henríquez, G., Gomez, A., Guerrero, E., & Narayan, M.
- Affiliations
- Department of Environmental Science and Engineering, the University of Texas at El Paso (UTEP), El Paso, Texas 79968, United States
- The University of Texas at El Paso (US)
- Corresponding author
- Narayan, Mahesh
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-08-21
- Volume
- 11
- Issue
- 19
- Pages
- 2915-2934
- ISSN
- 1948-7193 (ISSN-L)
- OpenAlex
- W3080099077
- Cited by
- 83
- References
- 246
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 15 · 2023: 21 · 2022: 16 · 2021: 8 · 2020: 2
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Chemical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services (#R25GM069621-11, 1SC3 GM111200 01A1)
- Les and Harriet Dodson Endowment
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- natural polyphenols, protein aggregation, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyloid-beta, tau protein, alpha-synuclein, huntingtin, epigallocatechin gallate, oleuropein aglycone, quercetin, proteinopathies, oxidative damage, neuroprotection
- MeSH terms
- Alzheimer Disease, Animals, Amyloid beta-Peptides, alpha-Synuclein, Polyphenols, Protein Aggregates
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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